This work identifies the Energy Loss Phenomenon in Reinforcement Learning from Human Feedback (RLHF) and its connection to reward hacking. Specifically, energy loss in the final layer of a Large Language Model (LLM) gradually increases during the RL process, with an excessive increase in energy loss characterizing reward hacking. Beyond empirical analysis, we further provide a theoretical foundation by proving that, under mild conditions, the increased energy loss reduces the upper bound of contextual relevance in LLMs, which is a critical aspect of reward hacking as the reduced contextual relevance typically indicates overfitting to reward model-favored patterns in RL. To address this issue, we propose an Energy loss-aware PPO algorithm (EPPO) which penalizes the increase in energy loss in the LLM's final layer during reward calculation to prevent excessive energy loss, thereby mitigating reward hacking. We theoretically show that EPPO can be conceptually interpreted as an entropy-regularized RL algorithm, which provides deeper insights into its effectiveness. Extensive experiments across various LLMs and tasks demonstrate the commonality of the energy loss phenomenon, as well as the effectiveness of EPPO in mitigating reward hacking and improving RLHF performance.

This paper addresses the challenges of creating efficient and high-quality datasets for machine learning potential functions. We present a novel approach, termed DV-LAE (Difference Vectors based on Local Atomic Environments), which utilizes the properties of atomic local environments and employs histogram statistics to generate difference vectors. This technique facilitates dataset screening and optimization, effectively minimizing redundancy while maintaining data diversity. We have validated the optimized datasets in high-temperature and high-pressure hydrogen systems as well as the {\alpha}-Fe/H binary system, demonstrating a significant reduction in computational resource usage without compromising prediction accuracy. Additionally, our method has revealed new structures that emerge during simulations but were underrepresented in the initial training datasets. The redundancy in the datasets and the distribution of these new structures can be visually analyzed through the visualization of difference vectors. This approach enhances our understanding of the characteristics of these newly formed structures and their impact on physical processes.

In vitro fertilization-embryo transfer (IVF-ET) stands as one of the most prevalent treatments for infertility. During an IVF-ET cycle, the time interval between trigger shot and oocyte pickup (OPU) is a pivotal period for follicular maturation, which determines mature oocytes yields and impacts the success of subsequent procedures. However, accurately predicting this interval is severely hindered by the variability of clinicians'experience that often leads to suboptimal oocyte retrieval rate. To address this challenge, we propose ILETIA, the first machine learning-based method that could predict the optimal trigger-OPU interval for patients receiving progestin-primed ovarian stimulation (PPOS) protocol. Specifically, ILETIA leverages a Transformer to learn representations from clinical tabular data, and then employs gradient-boosted trees for interval prediction. For model training and evaluating, we compiled a dataset PPOS-DS of nearly ten thousand patients receiving PPOS protocol, the largest such dataset to our knowledge. Experimental results demonstrate that our method achieves strong performance (AUROC = 0.889), outperforming both clinicians and other widely used computational models. Moreover, ILETIA also supports premature ovulation risk prediction in a specific OPU time (AUROC = 0.838). Collectively, by enabling more precise and individualized decisions, ILETIA has the potential to improve clinical outcomes and lay the foundation for future IVF-ET research.

Recent advancement in computer vision has significantly lowered the barriers to artistic creation. Exemplar-based image translation methods have attracted much attention due to flexibility and controllability. However, these methods hold assumptions regarding semantics or require semantic information as the input, while accurate semantics is not easy to obtain in artistic images. Besides, these methods suffer from cross-domain artifacts due to training data prior and generate imprecise structure due to feature compression in the spatial domain. In this paper, we propose an arbitrary Style Image Manipulation Network (SIM-Net), which leverages semantic-free information as guidance and a region transportation strategy in a self-supervised manner for image generation. Our method balances computational efficiency and high resolution to a certain extent. Moreover, our method facilitates zero-shot style image manipulation. Both qualitative and quantitative experiments demonstrate the superiority of our method over state-of-the-art methods.Code is available at https://github.com/SnailForce/SIM-Net.

Aligning large language models (LLMs) with human values, particularly in the face of stealthy and complex jailbreaks, presents a formidable challenge. In this study, we present a simple yet highly effective defense strategy, i.e., Intention Analysis Prompting (IAPrompt). The principle behind is to trigger LLMs' inherent self-correct and improve ability through a two-stage process: 1) essential intention analysis, and 2) policy-aligned response. Notably, IAPrompt is an inference-only method, thus could enhance the safety of LLMs without compromising their helpfulness. Extensive experiments on SAP200 and DAN benchmarks across Vicuna, ChatGLM, MPT, DeepSeek, and GPT-3.5 show that IAPrompt could consistently and significantly reduce the harmfulness in response (averagely -46.5% attack success rate) and maintain the general helpfulness. Further analyses present some insights into how our method works. To facilitate reproducibility, We release our code and scripts at: https://github.com/alphadl/SafeLLM_with_IntentionAnalysis

Improving neural machine translation (NMT) systems with prompting has achieved significant progress in recent years. In this work, we focus on how to integrate multi-knowledge, multiple types of knowledge, into NMT models to enhance the performance with prompting. We propose a unified framework, which can integrate effectively multiple types of knowledge including sentences, terminologies/phrases and translation templates into NMT models. We utilize multiple types of knowledge as prefix-prompts of input for the encoder and decoder of NMT models to guide the translation process. The approach requires no changes to the model architecture and effectively adapts to domain-specific translation without retraining. The experiments on English-Chinese and English-German translation demonstrate that our approach significantly outperform strong baselines, achieving high translation quality and terminology match accuracy.

Interactive machine translation (IMT) has emerged as a progression of the computer-aided translation paradigm, where the machine translation system and the human translator collaborate to produce high-quality translations. This paper introduces Synslator, a user-friendly computer-aided translation (CAT) tool that not only supports IMT, but is adept at online learning with real-time translation memories. To accommodate various deployment environments for CAT services, Synslator integrates two different neural translation models to handle translation memories for online learning. Additionally, the system employs a language model to enhance the fluency of translations in an interactive mode. In evaluation, we have confirmed the effectiveness of online learning through the translation models, and have observed a 13% increase in post-editing efficiency with the interactive functionalities of Synslator. A tutorial video is available at:https://youtu.be/K0vRsb2lTt8.

Purpose: Congenital heart defect (CHD) is the most common birth defect. Thoracic echocardiography (TTE) can provide sufficient cardiac structure information, evaluate hemodynamics and cardiac function, and is an effective method for atrial septal defect (ASD) examination. This paper aims to study a deep learning method based on cardiac ultrasound video to assist in ASD diagnosis. Materials and methods: We select two standard views of the atrial septum (subAS) and low parasternal four-compartment view (LPS4C) as the two views to identify ASD. We enlist data from 300 children patients as part of a double-blind experiment for five-fold cross-validation to verify the performance of our model. In addition, data from 30 children patients (15 positives and 15 negatives) are collected for clinician testing and compared to our model test results (these 30 samples do not participate in model training). We propose an echocardiography video-based atrial septal defect diagnosis system. In our model, we present a block random selection, maximal agreement decision and frame sampling strategy for training and testing respectively, resNet18 and r3D networks are used to extract the frame features and aggregate them to build a rich video-level representation. Results: We validate our model using our private dataset by five-cross validation. For ASD detection, we achieve 89.33 AUC, 84.95 accuracy, 85.70 sensitivity, 81.51 specificity and 81.99 F1 score. Conclusion: The proposed model is multiple instances learning-based deep learning model for video atrial septal defect detection which effectively improves ASD detection accuracy when compared to the performances of previous networks and clinical doctors.

Machine translation technology has made great progress in recent years, but it cannot guarantee error free results. Human translators perform post editing on machine translations to correct errors in the scene of computer aided translation. In favor of expediting the post editing process, many works have investigated machine translation in interactive modes, in which machines can automatically refine the rest of translations constrained by human's edits. Translation Suggestion (TS), as an interactive mode to assist human translators, requires machines to generate alternatives for specific incorrect words or phrases selected by human translators. In this paper, we utilize the parameterized objective function of neural machine translation (NMT) and propose a novel constrained decoding algorithm, namely Prefix Suffix Guided Decoding (PSGD), to deal with the TS problem without additional training. Compared to the state of the art lexically constrained decoding method, PSGD improves translation quality by an average of $10.87$ BLEU and $8.62$ BLEU on the WeTS and the WMT 2022 Translation Suggestion datasets, respectively, and reduces decoding time overhead by an average of 63.4% tested on the WMT translation datasets. Furthermore, on both of the TS benchmark datasets, it is superior to other supervised learning systems trained with TS annotated data.

Lexically constrained neural machine translation (LCNMT), which controls the translation generation with pre-specified constraints, is important in many practical applications. Current approaches to LCNMT typically assume that the pre-specified lexical constraints are contextually appropriate. This assumption limits their application to real-world scenarios where a source lexicon may have multiple target constraints, and disambiguation is needed to select the most suitable one. In this paper, we propose disambiguated LCNMT (D-LCNMT) to solve the problem. D-LCNMT is a robust and effective two-stage framework that disambiguates the constraints based on contexts at first, then integrates the disambiguated constraints into LCNMT. Experimental results show that our approach outperforms strong baselines including existing data augmentation based approaches on benchmark datasets, and comprehensive experiments in scenarios where a source lexicon corresponds to multiple target constraints demonstrate the constraint disambiguation superiority of our approach.