The increasing use of vision-language models (VLMs) in healthcare applications presents great challenges related to hallucinations, in which the models may generate seemingly plausible results that are in fact incorrect. Such hallucinations can jeopardize clinical decision making, potentially harming the diagnosis and treatments. In this work, we propose MedHallTune, a large-scale benchmark designed specifically to evaluate and mitigate hallucinations in medical VLMs. Comprising over 100,000 images and 1,000,000 instruction pairs, MedHallTune includes both hallucination and non-hallucination samples, each with ground-truth annotations. We conduct a comprehensive evaluation of current medical and general VLMs using MedHallTune, assessing their performance across key metrics, including clinical accuracy, relevance, detail level, and risk level. The experimental results show that fine-tuning with MedHallTune successfully improves the ability of several existing models to manage hallucinations and boost their zero-shot performance on downstream visual-question-answering (VQA) tasks, making them more reliable for practical medical applications. Our work contributes to the development of more trustworthy VLMs. Codes and dataset will be available at MedHallTune.

Glaucoma is one of the major eye diseases that leads to progressive optic nerve fiber damage and irreversible blindness, afflicting millions of individuals. Glaucoma forecast is a good solution to early screening and intervention of potential patients, which is helpful to prevent further deterioration of the disease. It leverages a series of historical fundus images of an eye and forecasts the likelihood of glaucoma occurrence in the future. However, the irregular sampling nature and the imbalanced class distribution are two challenges in the development of disease forecasting approaches. To this end, we introduce the Multi-scale Spatio-temporal Transformer Network (MST-former) based on the transformer architecture tailored for sequential image inputs, which can effectively learn representative semantic information from sequential images on both temporal and spatial dimensions. Specifically, we employ a multi-scale structure to extract features at various resolutions, which can largely exploit rich spatial information encoded in each image. Besides, we design a time distance matrix to scale time attention in a non-linear manner, which could effectively deal with the irregularly sampled data. Furthermore, we introduce a temperature-controlled Balanced Softmax Cross-entropy loss to address the class imbalance issue. Extensive experiments on the Sequential fundus Images for Glaucoma Forecast (SIGF) dataset demonstrate the superiority of the proposed MST-former method, achieving an AUC of 98.6% for glaucoma forecasting. Besides, our method shows excellent generalization capability on the Alzheimer's Disease Neuroimaging Initiative (ADNI) MRI dataset, with an accuracy of 90.3% for mild cognitive impairment and Alzheimer's disease prediction, outperforming the compared method by a large margin.

The non-local module is designed for capturing long-range spatio-temporal dependencies in images and videos. Although having shown excellent performance, it lacks the mechanism to model the interactions between positions across channels, which are of vital importance in recognizing fine-grained objects and actions. To address this limitation, we generalize the non-local module and take the correlations between the positions of any two channels into account. This extension utilizes the compact representation for multiple kernel functions with Taylor expansion that makes the generalized non-local module in a fast and low-complexity computation flow. Moreover, we implement our generalized non-local method within channel groups to ease the optimization. Experimental results illustrate the clear-cut improvements and practical applicability of the generalized non-local module on both fine-grained object recognition and video classification. Code is available at: https://github.com/KaiyuYue/cgnl-network.pytorch.

The non-local module is designed for capturing long-range spatio-temporal dependencies in images and videos. Although having shown excellent performance, it lacks the mechanism to model the interactions between positions across channels, which are of vital importance in recognizing fine-grained objects and actions. To address this limitation, we generalize the non-local module and take the correlations between the positions of any two channels into account. This extension utilizes the compact representation for multiple kernel functions with Taylor expansion that makes the generalized non-local module in a fast and low-complexity computation flow. Moreover, we implement our generalized non-local method within channel groups to ease the optimization. Experimental results illustrate the clear-cut improvements and practical applicability of the generalized non-local module on both fine-grained object recognition and video classification. Code is available at: https://github.com/KaiyuYue/cgnl-network.pytorch.