Recently, Vision-Language Models (VLMs) have achieved remarkable progress in multimodal tasks, and multimodal instruction data serves as the foundation for enhancing VLM capabilities. Despite the availability of several open-source multimodal datasets, limitations in the scale and quality of open-source instruction data hinder the performance of VLMs trained on these datasets, leading to a significant gap compared to models trained on closed-source data. To address this challenge, we introduce Infinity-MM, a large-scale multimodal instruction dataset. We collected the available multimodal instruction datasets and performed unified preprocessing, resulting in a dataset with over 40 million samples that ensures diversity and accuracy. Furthermore, to enable large-scale expansion of instruction data and support the continuous acquisition of high-quality data, we propose a synthetic instruction generation method based on a tagging system and open-source VLMs. By establishing correspondences between different types of images and associated instruction types, this method can provide essential guidance during data synthesis. Leveraging this high-quality data, we have trained a 2-billion-parameter Vision-Language Model, Aquila-VL-2B, which achieves state-of-the-art (SOTA) performance among models of similar scale. The data is available at: https://huggingface.co/datasets/BAAI/Infinity-MM.

The advancement of machine learning and the availability of large-scale reaction datasets have accelerated the development of data-driven models for computer-aided synthesis planning (CASP) in the past decade. Here, we detail the newest version of ASKCOS, an open source software suite for synthesis planning that makes available several research advances in a freely available, practical tool. Four one-step retrosynthesis models form the basis of both interactive planning and automatic planning modes. Retrosynthetic planning is complemented by other modules for feasibility assessment and pathway evaluation, including reaction condition recommendation, reaction outcome prediction, and auxiliary capabilities such as solubility prediction and quantum mechanical descriptor prediction. ASKCOS has assisted hundreds of medicinal, synthetic, and process chemists in their day-to-day tasks, complementing expert decision making. It is our belief that CASP tools like ASKCOS are an important part of modern chemistry research, and that they offer ever-increasing utility and accessibility.

The o1 model series is trained with large-scale reinforcement learning to reason using chain of thought. These advanced reasoning capabilities provide new avenues for improving the safety and robustness of our models. In particular, our models can reason about our safety policies in context when responding to potentially unsafe prompts, through deliberative alignment. This leads to state-of-the-art performance on certain benchmarks for risks such as generating illicit advice, choosing stereotyped responses, and succumbing to known jailbreaks. Training models to incorporate a chain of thought before answering has the potential to unlock substantial benefits, while also increasing potential risks that stem from heightened intelligence. Our results underscore the need for building robust alignment methods, extensively stress-testing their efficacy, and maintaining meticulous risk management protocols. This report outlines the safety work carried out for the OpenAI o1 and OpenAI o1-mini models, including safety evaluations, external red teaming, and Preparedness Framework evaluations.

Computer-aided synthesis planning (CASP) algorithms have demonstrated expert-level abilities in planning retrosynthetic routes to molecules of low to moderate complexity. However, current search methods assume the sufficiency of reaching arbitrary building blocks, failing to address the common real-world constraint where using specific molecules is desired. To this end, we present a formulation of synthesis planning with starting material constraints. Under this formulation, we propose Double-Ended Synthesis Planning (DESP), a novel CASP algorithm under a bidirectional graph search scheme that interleaves expansions from the target and from the goal starting materials to ensure constraint satisfiability. The search algorithm is guided by a goal-conditioned cost network learned offline from a partially observed hypergraph of valid chemical reactions. We demonstrate the utility of DESP in improving solve rates and reducing the number of search expansions by biasing synthesis planning towards expert goals on multiple new benchmarks. DESP can make use of existing one-step retrosynthesis models, and we anticipate its performance to scale as these one-step model capabilities improve.

We report the development of GPT-4, a large-scale, multimodal model which can accept image and text inputs and produce text outputs. While less capable than humans in many real-world scenarios, GPT-4 exhibits human-level performance on various professional and academic benchmarks, including passing a simulated bar exam with a score around the top 10% of test takers. GPT-4 is a Transformer-based model pre-trained to predict the next token in a document. The post-training alignment process results in improved performance on measures of factuality and adherence to desired behavior. A core component of this project was developing infrastructure and optimization methods that behave predictably across a wide range of scales. This allowed us to accurately predict some aspects of GPT-4's performance based on models trained with no more than 1/1,000th the compute of GPT-4.

We study the problem of visual surface inspection of a bridge for defects using an Unmanned Aerial Vehicle (UAV). We do not assume that the geometric model of the bridge is known beforehand. Our planner, termed GATSBI, plans a path in a receding horizon fashion to inspect all points on the surface of the bridge. The input to GATSBI consists of a 3D occupancy map created online with LiDAR scans. Occupied voxels corresponding to the bridge in this map are semantically segmented and used to create a bridge-only occupancy map. Inspecting a bridge voxel requires the UAV to take images from a desired viewing angle and distance. We then create a Generalized Traveling Salesperson Problem (GTSP) instance to cluster candidate viewpoints for inspecting the bridge voxels and use an off-the-shelf GTSP solver to find the optimal path for the given instance. As the algorithm sees more parts of the environment over time, it replans the path to inspect novel parts of the bridge while avoiding obstacles. We evaluate the performance of our algorithm through high-fidelity simulations conducted in AirSim and real-world experiments. We compare the performance of GATSBI with a classical exploration algorithm. Our evaluation reveals that targeting the inspection to only the segmented bridge voxels and planning carefully using a GTSP solver leads to a more efficient and thorough inspection than the baseline algorithm.

We present techniques to measure crop heights using a 3D Light Detection and Ranging (LiDAR) sensor mounted on an Unmanned Aerial Vehicle (UAV). Knowing the height of plants is crucial to monitor their overall health and growth cycles, especially for high-throughput plant phenotyping. We present a methodology for extracting plant heights from 3D LiDAR point clouds, specifically focusing on plot-based phenotyping environments. We also present a toolchain that can be used to create phenotyping farms for use in Gazebo simulations. The tool creates a randomized farm with realistic 3D plant and terrain models. We conducted a series of simulations and hardware experiments in controlled and natural settings. Our algorithm was able to estimate the plant heights in a field with 112 plots with a root mean square error (RMSE) of 6.1 cm. This is the first such dataset for 3D LiDAR from an airborne robot over a wheat field. The developed simulation toolchain, algorithmic implementation, and datasets can be found on the GitHub repository located at https://github.com/hsd1121/PointCloudProcessing.