A wide variety of Artificial Intelligence (AI) techniques, from expert systems to machine learning to robotics, are needed in the field of synthetic biology. This paper describes the design-build-test engineering cycle and lists some challenges in which AI can help.

The complexity and tight integration of electromechanical systems often makes them "brittle" and hard to modify in response to changing requirements. We aim to remedy this by capturing expert knowledge as functional blueprints, an idea inspired by regulatory processes that occur in natural morphogenesis. We then apply this knowledge in an intelligent design variation tool. When a user modifies a design, our tool uses functional blueprints to modify other components in response, thereby maintaining integration and reducing the need for costly search or constraint solving. In this paper, we refine the functional blueprint concept and discuss practical issues in applying it to electromechanical systems. We then validate our approach with a case study applying our prototype tool to create variants of a miniDroid robot and by empirical evaluation of convergence dynamics of networks of functional blueprints.

Preferences play an important role in our everyday lives. CP-networks, or CP-nets in short, are graphical models for representing conditional qualitative preferences under ceteris paribus ("all else being equal") assumptions. Despite their intuitive nature and rich representation, dominance testing with CP-nets is computationally complex, even when the CP-nets are restricted to binary-valued preferences. Tractable algorithms exist for binary CP-nets, but these algorithms are incomplete for multi-valued CPnets. In this paper, we identify a class of multivalued CP-nets, which we call more-or-less CPnets, that have the same computational complexity as binary CP-nets. More-or-less CP-nets exploit the monotonicity of the attribute values and use intervals to aggregate values that induce similar preferences. We then present a search control rule for dominance testing that effectively prunes the search space while preserving completeness.