This paper presents a closed-loop magnetic manipulation framework for robotic transesophageal echocardiography (TEE) acquisitions. Different from previous work on intracorporeal robotic ultrasound acquisitions that focus on continuum robot control, we first investigate the use of magnetic control methods for more direct, intuitive, and accurate manipulation of the distal tip of the probe. We modify a standard TEE probe by attaching a permanent magnet and an inertial measurement unit sensor to the probe tip and replacing the flexible gastroscope with a soft tether containing only wires for transmitting ultrasound signals, and show that 6-DOF localization and 5-DOF closed-loop control of the probe can be achieved with an external permanent magnet based on the fusion of internal inertial measurement and external magnetic field sensing data. The proposed method does not require complex structures or motions of the actuator and the probe compared with existing magnetic manipulation methods. We have conducted extensive experiments to validate the effectiveness of the framework in terms of localization accuracy, update rate, workspace size, and tracking accuracy. In addition, our results obtained on a realistic cardiac tissue-mimicking phantom show that the proposed framework is applicable in real conditions and can generally meet the requirements for tele-operated TEE acquisitions.

Robotic ultrasound (US) systems have shown great potential to make US examinations easier and more accurate. Recently, various machine learning techniques have been proposed to realize automatic US image interpretation for robotic US acquisition tasks. However, obtaining large amounts of real US imaging data for training is usually expensive or even unfeasible in some clinical applications. An alternative is to build a simulator to generate synthetic US data for training, but the differences between simulated and real US images may result in poor model performance. This work presents a Sim2Real framework to efficiently learn robotic US image analysis tasks based only on simulated data for real-world deployment. A style transfer module is proposed based on unsupervised contrastive learning and used as a preprocessing step to convert the real US images into the simulation style. Thereafter, a task-relevant model is designed to combine CNNs with vision transformers to generate the task-dependent prediction with improved generalization ability. We demonstrate the effectiveness of our method in an image regression task to predict the probe position based on US images in robotic transesophageal echocardiography (TEE). Our results show that using only simulated US data and a small amount of unlabelled real data for training, our method can achieve comparable performance to semi-supervised and fully supervised learning methods. Moreover, the effectiveness of our previously proposed CT-based US image simulation method is also indirectly confirmed.

Ultrasound (US) imaging is commonly used to assist in the diagnosis and interventions of spine diseases, while the standardized US acquisitions performed by manually operating the probe require substantial experience and training of sonographers. In this work, we propose a novel dual-agent framework that integrates a reinforcement learning (RL) agent and a deep learning (DL) agent to jointly determine the movement of the US probe based on the real-time US images, in order to mimic the decision-making process of an expert sonographer to achieve autonomous standard view acquisitions in spinal sonography. Moreover, inspired by the nature of US propagation and the characteristics of the spinal anatomy, we introduce a view-specific acoustic shadow reward to utilize the shadow information to implicitly guide the navigation of the probe toward different standard views of the spine. Our method is validated in both quantitative and qualitative experiments in a simulation environment built with US data acquired from 17 volunteers. The average navigation accuracy toward different standard views achieves 5.18mm/5.25deg and 12.87mm/17.49deg in the intra- and inter-subject settings, respectively. The results demonstrate that our method can effectively interpret the US images and navigate the probe to acquire multiple standard views of the spine.

Abdominal ultrasound imaging has been widely used to assist in the diagnosis and treatment of various abdominal organs. In order to shorten the examination time and reduce the cognitive burden on the sonographers, we present a classification method that combines the deep learning techniques and k-Nearest-Neighbor (k-NN) classification to automatically recognize various abdominal organs in the ultrasound images in real time. Fine-tuned deep neural networks are used in combination with PCA dimension reduction to extract high-level features from raw ultrasound images, and a k-NN classifier is employed to predict the abdominal organ in the image. We demonstrate the effectiveness of our method in the task of ultrasound image classification to automatically recognize six abdominal organs. A comprehensive comparison of different configurations is conducted to study the influence of different feature extractors and classifiers on the classification accuracy. Both quantitative and qualitative results show that with minimal training effort, our method can "lazily" recognize the abdominal organs in the ultrasound images in real time with an accuracy of 96.67%. Our implementation code is publicly available at: https://github.com/LeeKeyu/abdominal_ultrasound_classification.

Autonomous ultrasound (US) acquisition is an important yet challenging task, as it involves interpretation of the highly complex and variable images and their spatial relationships. In this work, we propose a deep reinforcement learning framework to autonomously control the 6-D pose of a virtual US probe based on real-time image feedback to navigate towards the standard scan planes under the restrictions in real-world US scans. Furthermore, we propose a confidence-based approach to encode the optimization of image quality in the learning process. We validate our method in a simulation environment built with real-world data collected in the US imaging of the spine. Experimental results demonstrate that our method can perform reproducible US probe navigation towards the standard scan plane with an accuracy of $4.91mm/4.65^\circ$ in the intra-patient setting, and accomplish the task in the intra- and inter-patient settings with a success rate of $92\%$ and $46\%$, respectively. The results also show that the introduction of image quality optimization in our method can effectively improve the navigation performance.