Multi-modality magnetic resonance imaging data with various sequences facilitate the early diagnosis, tumor segmentation, and disease staging in the management of nasopharyngeal carcinoma (NPC). The lack of publicly available, comprehensive datasets limits advancements in diagnosis, treatment planning, and the development of machine learning algorithms for NPC. Addressing this critical need, we introduce the first comprehensive NPC MRI dataset, encompassing MR axial imaging of 277 primary NPC patients. This dataset includes T1-weighted, T2-weighted, and contrast-enhanced T1-weighted sequences, totaling 831 scans. In addition to the corresponding clinical data, manually annotated and labeled segmentations by experienced radiologists offer high-quality data resources from untreated primary NPC.

Objective: Subcutaneous Immunotherapy (SCIT) is the long-lasting causal treatment of allergic rhinitis. How to enhance the adherence of patients to maximize the benefit of allergen immunotherapy (AIT) plays a crucial role in the management of AIT. This study aims to leverage novel machine learning models to precisely predict the risk of non-adherence of patients and related systematic symptom scores, to provide a novel approach in the management of long-term AIT. Methods: The research develops and analyzes two models, Sequential Latent Actor-Critic (SLAC) and Long Short-Term Memory (LSTM), evaluating them based on scoring and adherence prediction capabilities. Results: Excluding the biased samples at the first time step, the predictive adherence accuracy of the SLAC models is from $60\,\%$ to $72\%$, and for LSTM models, it is $66\,\%$ to $84\,\%$, varying according to the time steps. The range of Root Mean Square Error (RMSE) for SLAC models is between $0.93$ and $2.22$, while for LSTM models it is between $1.09$ and $1.77$. Notably, these RMSEs are significantly lower than the random prediction error of $4.55$. Conclusion: We creatively apply sequential models in the long-term management of SCIT with promising accuracy in the prediction of SCIT nonadherence in Allergic Rhinitis (AR) patients. While LSTM outperforms SLAC in adherence prediction, SLAC excels in score prediction for patients undergoing SCIT for AR. The state-action-based SLAC adds flexibility, presenting a novel and effective approach for managing long-term AIT.

In addition to the shared weights of the synaptic connections, our new neural network includes the synaptic effective range weights for both the forward and back propagation. We try to simulate the functions of prefrontal lobe, amygdala, and hippocampus by the Deep learning model of upstream and downstream brain regions(DLMOUADBR). Along the forward propagation, the negative memory gradually increases. Along the back propagation, the optimization order will increase. Memory flow may be considered to be the transmission of the rate of change of the architecture, then the nth cortex is the nth derivative of brain plasticity. Astrocytic cortex memory persistence factor and astrocytes phagocytose synapses inhibit local synaptic accumulation, and the model inspires experiments. The memory Generation-Consolidation-Loss model tries to explain 15 phenomena of Alzheimer's disease based on the DLMOUADBR and reverse turbulence. We consider the Heart-Brain model to reference to non-classical quantum entanglement experiments. And turbulent movement of brain regions through mnemonic spiral. The study first showed that mnemonic architecture formula-logarithmic spiral, turbulent movement in brain regions is only energy loss and memory engrams are approximate. This explains the dynamics cause of shaping in the geometry of the brain, related to the turbulent movement of the logarithmic spiral of the brain. In simulation, it is possible that thicker cortices and more diverse individuals within the brain could have high IQ, but thickest cortices and most diverse individuals may have low IQ in simulation and tries to give the mechanism of Cognitive impairment.

Numerous approaches have attempted to interpret deep neural networks (DNNs) by attributing the prediction of DNN to its input features. One of the well-studied attribution methods is Integrated Gradients (IG). Specifically, the choice of baselines for IG is a critical consideration for generating meaningful and unbiased explanations for model predictions in different scenarios. However, current practice of exploiting a single baseline fails to fulfill this ambition, thus demanding multiple baselines. Fortunately, the inherent connection between IG and Aumann-Shapley Value forms a unique perspective to rethink the design of baselines. Under certain hypothesis, we theoretically analyse that a set of baseline aligns with the coalitions in Shapley Value. Thus, we propose a novel baseline construction method called Shapley Integrated Gradients (SIG) that searches for a set of baselines by proportional sampling to partly simulate the computation path of Shapley Value. Simulations on GridWorld show that SIG approximates the proportion of Shapley Values. Furthermore, experiments conducted on various image tasks demonstrate that compared to IG using other baseline methods, SIG exhibits an improved estimation of feature's contribution, offers more consistent explanations across diverse applications, and is generic to distinct data types or instances with insignificant computational overhead.

Item representation holds significant importance in recommendation systems, which encompasses domains such as news, retail, and videos. Retrieval and ranking models utilise item representation to capture the user-item relationship based on user behaviours. While existing representation learning methods primarily focus on optimising item-based mechanisms, such as attention and sequential modelling. However, these methods lack a modelling mechanism to directly reflect user interests within the learned item representations. Consequently, these methods may be less effective in capturing user interests indirectly. To address this challenge, we propose a novel Interest-aware Capsule network (IaCN) recommendation model, a model-agnostic framework that directly learns interest-oriented item representations. IaCN serves as an auxiliary task, enabling the joint learning of both item-based and interest-based representations. This framework adopts existing recommendation models without requiring substantial redesign. We evaluate the proposed approach on benchmark datasets, exploring various scenarios involving different deep neural networks, behaviour sequence lengths, and joint learning ratios of interest-oriented item representations. Experimental results demonstrate significant performance enhancements across diverse recommendation models, validating the effectiveness of our approach.

Real-world cooperation often requires intensive coordination among agents simultaneously. This task has been extensively studied within the framework of cooperative multi-agent reinforcement learning (MARL), and value decomposition methods are among those cutting-edge solutions. However, traditional methods that learn the value function as a monotonic mixing of per-agent utilities cannot solve the tasks with non-monotonic returns. This hinders their application in generic scenarios. Recent methods tackle this problem from the perspective of implicit credit assignment by learning value functions with complete expressiveness or using additional structures to improve cooperation. However, they are either difficult to learn due to large joint action spaces or insufficient to capture the complicated interactions among agents which are essential to solving tasks with non-monotonic returns. To address these problems, we propose a novel explicit credit assignment method to address the non-monotonic problem. Our method, Adaptive Value decomposition with Greedy Marginal contribution (AVGM), is based on an adaptive value decomposition that learns the cooperative value of a group of dynamically changing agents. We first illustrate that the proposed value decomposition can consider the complicated interactions among agents and is feasible to learn in large-scale scenarios. Then, our method uses a greedy marginal contribution computed from the value decomposition as an individual credit to incentivize agents to learn the optimal cooperative policy. We further extend the module with an action encoder to guarantee the linear time complexity for computing the greedy marginal contribution. Experimental results demonstrate that our method achieves significant performance improvements in several non-monotonic domains.

Determining causal effects of temporal multi-intervention assists decision-making. Restricted by time-varying bias, selection bias, and interactions of multiple interventions, the disentanglement and estimation of multiple treatment effects from individual temporal data is still rare. To tackle these challenges, we propose a comprehensive framework of temporal counterfactual forecasting from an individual multiple treatment perspective (TCFimt). TCFimt constructs adversarial tasks in a seq2seq framework to alleviate selection and time-varying bias and designs a contrastive learning-based block to decouple a mixed treatment effect into separated main treatment effects and causal interactions which further improves estimation accuracy. Through implementing experiments on two real-world datasets from distinct fields, the proposed method shows satisfactory performance in predicting future outcomes with specific treatments and in choosing optimal treatment type and timing than state-of-the-art methods.