While deep generative models have significantly advanced representation learning, they may inherit or amplify biases and fairness issues by encoding sensitive attributes alongside predictive features. Enforcing strict independence in disentanglement is often unrealistic when target and sensitive factors are naturally correlated. To address this challenge, we propose CAD-VAE (Correlation-Aware Disentangled VAE), which introduces a correlated latent code to capture the shared information between target and sensitive attributes. Given this correlated latent, our method effectively separates overlapping factors without extra domain knowledge by directly minimizing the conditional mutual information between target and sensitive codes. A relevance-driven optimization strategy refines the correlated code by efficiently capturing essential correlated features and eliminating redundancy. Extensive experiments on benchmark datasets demonstrate that CAD-VAE produces fairer representations, realistic counterfactuals, and improved fairness-aware image editing.

Accurate prediction of CB2 receptor ligand activity is pivotal for advancing drug discovery targeting this receptor, which is implicated in inflammation, pain management, and neurodegenerative conditions. Although conventional machine learning and deep learning techniques have shown promise, their limited interpretability remains a significant barrier to rational drug design. In this work, we introduce CB2former, a framework that combines a Graph Convolutional Network with a Transformer architecture to predict CB2 receptor ligand activity. By leveraging the Transformer's self attention mechanism alongside the GCN's structural learning capability, CB2former not only enhances predictive performance but also offers insights into the molecular features underlying receptor activity. We benchmark CB2former against diverse baseline models including Random Forest, Support Vector Machine, K Nearest Neighbors, Gradient Boosting, Extreme Gradient Boosting, Multilayer Perceptron, Convolutional Neural Network, and Recurrent Neural Network and demonstrate its superior performance with an R squared of 0.685, an RMSE of 0.675, and an AUC of 0.940. Moreover, attention weight analysis reveals key molecular substructures influencing CB2 receptor activity, underscoring the model's potential as an interpretable AI tool for drug discovery. This ability to pinpoint critical molecular motifs can streamline virtual screening, guide lead optimization, and expedite therapeutic development. Overall, our results showcase the transformative potential of advanced AI approaches exemplified by CB2former in delivering both accurate predictions and actionable molecular insights, thus fostering interdisciplinary collaboration and innovation in drug discovery.

Video-based multimodal large language models (V-MLLMs) have shown vulnerability to adversarial examples in video-text multimodal tasks. However, the transferability of adversarial videos to unseen models--a common and practical real world scenario--remains unexplored. In this paper, we pioneer an investigation into the transferability of adversarial video samples across V-MLLMs. We find that existing adversarial attack methods face significant limitations when applied in black-box settings for V-MLLMs, which we attribute to the following shortcomings: (1) lacking generalization in perturbing video features, (2) focusing only on sparse key-frames, and (3) failing to integrate multimodal information. To address these limitations and deepen the understanding of V-MLLM vulnerabilities in black-box scenarios, we introduce the Image-to-Video MLLM (I2V-MLLM) attack. In I2V-MLLM, we utilize an image-based multimodal model (IMM) as a surrogate model to craft adversarial video samples. Multimodal interactions and temporal information are integrated to disrupt video representations within the latent space, improving adversarial transferability. In addition, a perturbation propagation technique is introduced to handle different unknown frame sampling strategies. Experimental results demonstrate that our method can generate adversarial examples that exhibit strong transferability across different V-MLLMs on multiple video-text multimodal tasks. Compared to white-box attacks on these models, our black-box attacks (using BLIP-2 as surrogate model) achieve competitive performance, with average attack success rates of 55.48% on MSVD-QA and 58.26% on MSRVTT-QA for VideoQA tasks, respectively. Our code will be released upon acceptance.

With the growing significance of network security, the classification of encrypted traffic has emerged as an urgent challenge. Traditional byte-based traffic analysis methods are constrained by the rigid granularity of information and fail to fully exploit the diverse correlations between bytes. To address these limitations, this paper introduces MH-Net, a novel approach for classifying network traffic that leverages multi-view heterogeneous traffic graphs to model the intricate relationships between traffic bytes. The essence of MH-Net lies in aggregating varying numbers of traffic bits into multiple types of traffic units, thereby constructing multi-view traffic graphs with diverse information granularities. By accounting for different types of byte correlations, such as header-payload relationships, MH-Net further endows the traffic graph with heterogeneity, significantly enhancing model performance. Notably, we employ contrastive learning in a multi-task manner to strengthen the robustness of the learned traffic unit representations. Experiments conducted on the ISCX and CIC-IoT datasets for both the packet-level and flow-level traffic classification tasks demonstrate that MH-Net achieves the best overall performance compared to dozens of SOTA methods.

The rapid advancement of generative artificial intelligence (AI) in recent years has profoundly reshaped modern lifestyles, necessitating a revolutionary architecture to support the growing demands for computational power. Cloud computing has become the driving force behind this transformation. However, it consumes significant power and faces computation security risks due to the reliance on extensive data centers and servers in the cloud. Reducing power consumption while enhancing computational scale remains persistent challenges in cloud computing. Here, we propose and experimentally demonstrate an optical cloud computing system that can be seamlessly deployed across edge-metro network. By modulating inputs and models into light, a wide range of edge nodes can directly access the optical computing center via the edge-metro network. The experimental validations show an energy efficiency of 118.6 mW/TOPs (tera operations per second), reducing energy consumption by two orders of magnitude compared to traditional electronic-based cloud computing solutions. Furthermore, it is experimentally validated that this architecture can perform various complex generative AI models through parallel computing to achieve image generation tasks.

Drug target binding affinity (DTA) is a key criterion for drug screening. Existing experimental methods are time-consuming and rely on limited structural and domain information. While learning-based methods can model sequence and structural information, they struggle to integrate contextual data and often lack comprehensive modeling of drug-target interactions. In this study, we propose a novel DTA prediction method, termed HGTDP-DTA, which utilizes dynamic prompts within a hybrid Graph-Transformer framework. Our method generates context-specific prompts for each drug-target pair, enhancing the model's ability to capture unique interactions. The introduction of prompt tuning further optimizes the prediction process by filtering out irrelevant noise and emphasizing task-relevant information, dynamically adjusting the input features of the molecular graph. The proposed hybrid Graph-Transformer architecture combines structural information from Graph Convolutional Networks (GCNs) with sequence information captured by Transformers, facilitating the interaction between global and local information. Additionally, we adopted the multi-view feature fusion method to project molecular graph views and affinity subgraph views into a common feature space, effectively combining structural and contextual information. Experiments on two widely used public datasets, Davis and KIBA, show that HGTDP-DTA outperforms state-of-the-art DTA prediction methods in both prediction performance and generalization ability.

Randomized Smoothing (RS) is currently a scalable certified defense method providing robustness certification against adversarial examples. Although significant progress has been achieved in providing defenses against $\ell_p$ adversaries, the interaction between the smoothing distribution and the robustness certification still remains vague. In this work, we comprehensively study the effect of two families of distributions, named Exponential Standard Gaussian (ESG) and Exponential General Gaussian (EGG) distributions, on Randomized Smoothing and Double Sampling Randomized Smoothing (DSRS). We derive an analytic formula for ESG's certified radius, which converges to the origin formula of RS as the dimension $d$ increases. Additionally, we prove that EGG can provide tighter constant factors than DSRS in providing $\Omega(\sqrt{d})$ lower bounds of $\ell_2$ certified radius, and thus further addresses the curse of dimensionality in RS. Our experiments on real-world datasets confirm our theoretical analysis of the ESG distributions, that they provide almost the same certification under different exponents $\eta$ for both RS and DSRS. In addition, EGG brings a significant improvement to the DSRS certification, but the mechanism can be different when the classifier properties are different. Compared to the primitive DSRS, the increase in certified accuracy provided by EGG is prominent, up to 6.4% on ImageNet.

Multivariate time series prediction is widely used in daily life, which poses significant challenges due to the complex correlations that exist at multi-grained levels. Unfortunately, the majority of current time series prediction models fail to simultaneously learn the correlations of multivariate time series at multi-grained levels, resulting in suboptimal performance. To address this, we propose a Multi-Grained Correlations-based Prediction (MGCP) Network, which simultaneously considers the correlations at three granularity levels to enhance prediction performance. Specifically, MGCP utilizes Adaptive Fourier Neural Operators and Graph Convolutional Networks to learn the global spatiotemporal correlations and inter-series correlations, enabling the extraction of potential features from multivariate time series at fine-grained and medium-grained levels. Additionally, MGCP employs adversarial training with an attention mechanism-based predictor and conditional discriminator to optimize prediction results at coarse-grained level, ensuring high fidelity between the generated forecast results and the actual data distribution. Finally, we compare MGCP with several state-of-the-art time series prediction algorithms on real-world benchmark datasets, and our results demonstrate the generality and effectiveness of the proposed model.

With the development of modern society, traffic volume continues to increase in most countries worldwide, leading to an increase in the rate of pavement damage Therefore, the real-time and highly accurate pavement damage detection and maintenance have become the current need. In this paper, an enhanced pavement damage detection method with CycleGAN and improved YOLOv5 algorithm is presented. We selected 7644 self-collected images of pavement damage samples as the initial dataset and augmented it by CycleGAN. Due to a substantial difference between the images generated by CycleGAN and real road images, we proposed a data enhancement method based on an improved Scharr filter, CycleGAN, and Laplacian pyramid. To improve the target recognition effect on a complex background and solve the problem that the spatial pyramid pooling-fast module in the YOLOv5 network cannot handle multiscale targets, we introduced the convolutional block attention module attention mechanism and proposed the atrous spatial pyramid pooling with squeeze-and-excitation structure. In addition, we optimized the loss function of YOLOv5 by replacing the CIoU with EIoU. The experimental results showed that our algorithm achieved a precision of 0.872, recall of 0.854, and mean average precision@0.5 of 0.882 in detecting three main types of pavement damage: cracks, potholes, and patching. On the GPU, its frames per second reached 68, meeting the requirements for real-time detection. Its overall performance even exceeded the current more advanced YOLOv7 and achieved good results in practical applications, providing a basis for decision-making in pavement damage detection and prevention.

Model-based reinforcement learning is a widely accepted solution for solving excessive sample demands. However, the predictions of the dynamics models are often not accurate enough, and the resulting bias may incur catastrophic decisions due to insufficient robustness. Therefore, it is highly desired to investigate how to improve the robustness of model-based RL algorithms while maintaining high sampling efficiency. In this paper, we propose Model-Based Double-dropout Planning (MBDP) to balance robustness and efficiency. MBDP consists of two kinds of dropout mechanisms, where the rollout-dropout aims to improve the robustness with a small cost of sample efficiency, while the model-dropout is designed to compensate for the lost efficiency at a slight expense of robustness. By combining them in a complementary way, MBDP provides a flexible control mechanism to meet different demands of robustness and efficiency by tuning two corresponding dropout ratios. The effectiveness of MBDP is demonstrated both theoretically and experimentally.