The joint progress of artificial neural networks (ANNs) and domain specific hardware accelerators such as GPUs and TPUs took over many domains of machine learning research. This development is accompanied by a rapid growth of the required computational demands for larger models and more data. Concurrently, emerging properties of foundation models such as in-context learning drive new opportunities for machine learning applications. However, the computational cost of such applications is a limiting factor of the technology in data centers, and more importantly in mobile devices and edge systems. To mediate the energy footprint and non-trivial latency of contemporary systems, neuromorphic computing systems deeply integrate computational principles of neurobiological systems by leveraging low-power analog and digital technologies. SpiNNaker2 is a digital neuromorphic chip developed for scalable machine learning. The event-based and asynchronous design of SpiNNaker2 allows the composition of large-scale systems involving thousands of chips. This work features the operating principles of SpiNNaker2 systems, outlining the prototype of novel machine learning applications. These applications range from ANNs over bio-inspired spiking neural networks to generalized event-based neural networks. With the successful development and deployment of SpiNNaker2, we aim to facilitate the advancement of event-based and asynchronous algorithms for future generations of machine learning systems.

Future developments in artificial intelligence will profit from the existence of novel, non-traditional substrates for brain-inspired computing. Neuromorphic computers aim to provide such a substrate that reproduces the brain's capabilities in terms of adaptive, low-power information processing. We present results from a prototype chip of the BrainScaleS-2 mixed-signal neuromorphic system that adopts a physical-model approach with a 1000-fold acceleration of spiking neural network dynamics relative to biological real time. Using the embedded plasticity processor, we both simulate the Pong arcade video game and implement a local plasticity rule that enables reinforcement learning, allowing the on-chip neural network to learn to play the game. The experiment demonstrates key aspects of the employed approach, such as accelerated and flexible learning, high energy efficiency and resilience to noise.