GPT-4o is an autoregressive omni model that accepts as input any combination of text, audio, image, and video, and generates any combination of text, audio, and image outputs. It's trained end-to-end across text, vision, and audio, meaning all inputs and outputs are processed by the same neural network. GPT-4o can respond to audio inputs in as little as 232 milliseconds, with an average of 320 milliseconds, which is similar to human response time in conversation. It matches GPT-4 Turbo performance on text in English and code, with significant improvement on text in non-English languages, while also being much faster and 50\% cheaper in the API. GPT-4o is especially better at vision and audio understanding compared to existing models. In line with our commitment to building AI safely and consistent with our voluntary commitments to the White House, we are sharing the GPT-4o System Card, which includes our Preparedness Framework evaluations. In this System Card, we provide a detailed look at GPT-4o's capabilities, limitations, and safety evaluations across multiple categories, focusing on speech-to-speech while also evaluating text and image capabilities, and measures we've implemented to ensure the model is safe and aligned. We also include third-party assessments on dangerous capabilities, as well as discussion of potential societal impacts of GPT-4o's text and vision capabilities.

We report the development of GPT-4, a large-scale, multimodal model which can accept image and text inputs and produce text outputs. While less capable than humans in many real-world scenarios, GPT-4 exhibits human-level performance on various professional and academic benchmarks, including passing a simulated bar exam with a score around the top 10% of test takers. GPT-4 is a Transformer-based model pre-trained to predict the next token in a document. The post-training alignment process results in improved performance on measures of factuality and adherence to desired behavior. A core component of this project was developing infrastructure and optimization methods that behave predictably across a wide range of scales. This allowed us to accurately predict some aspects of GPT-4's performance based on models trained with no more than 1/1,000th the compute of GPT-4.

The availability of property data is one of the major bottlenecks in the development of chemical processes, often requiring time-consuming and expensive experiments or limiting the design space to a small number of known molecules. This bottleneck has been the motivation behind the continuing development of predictive property models. For the property prediction of novel molecules, group contribution methods have been groundbreaking. In recent times, machine learning has joined the more established property prediction models. However, even with recent successes, the integration of physical constraints into machine learning models remains challenging. Physical constraints are vital to many thermodynamic properties, such as the Gibbs-Duhem relation, introducing an additional layer of complexity into the prediction. Here, we introduce SPT-NRTL, a machine learning model to predict thermodynamically consistent activity coefficients and provide NRTL parameters for easy use in process simulations. The results show that SPT-NRTL achieves higher accuracy than UNIFAC in the prediction of activity coefficients across all functional groups and is able to predict many vapor-liquid-equilibria with near experimental accuracy, as illustrated for the exemplary mixtures water/ethanol and chloroform/n-hexane. To ease the application of SPT-NRTL, NRTL-parameters of 100 000 000 mixtures are calculated with SPT-NRTL and provided online.

Knowledge of mixtures' phase equilibria is crucial in nature and technical chemistry. Phase equilibria calculations of mixtures require activity coefficients. However, experimental data on activity coefficients is often limited due to high cost of experiments. For an accurate and efficient prediction of activity coefficients, machine learning approaches have been recently developed. However, current machine learning approaches still extrapolate poorly for activity coefficients of unknown molecules. In this work, we introduce the SMILES-to-Properties-Transformer (SPT), a natural language processing network to predict binary limiting activity coefficients from SMILES codes. To overcome the limitations of available experimental data, we initially train our network on a large dataset of synthetic data sampled from COSMO-RS (10 Million data points) and then fine-tune the model on experimental data (20 870 data points). This training strategy enables SPT to accurately predict limiting activity coefficients even for unknown molecules, cutting the mean prediction error in half compared to state-of-the-art models for activity coefficient predictions such as COSMO-RS, UNIFAC, and improving on recent machine learning approaches.

A core issue with learning to optimize neural networks has been the lack of generalization to real world problems. To address this, we describe a system designed from a generalization-first perspective, learning to update optimizer hyperparameters instead of model parameters directly using novel features, actions, and a reward function. This system outperforms Adam at all neural network tasks including on modalities not seen during training. We achieve 2x speedups on ImageNet, and a 2.5x speedup on a language modeling task using over 5 orders of magnitude more compute than the training tasks.