In solving partial differential equations (PDEs), Fourier Neural Operators (FNOs) have exhibited notable effectiveness compared to Convolutional Neural Networks (CNNs). This paper presents clear empirical evidence through spectral analysis to elucidate the superiority of FNO over CNNs: FNO is significantly more capable of learning low-frequencies. This empirical evidence also unveils FNO's distinct low-frequency bias, which limits FNO's effectiveness in learning high-frequency information from PDE data. To tackle this challenge, we introduce SpecBoost, an ensemble learning framework that employs multiple FNOs to better capture high-frequency information. Specifically, a secondary FNO is utilized to learn the overlooked high-frequency information from the prediction residual of the initial FNO. Experiments demonstrate that SpecBoost noticeably enhances FNO's prediction accuracy on diverse PDE applications, achieving an up to 71% improvement.

Although Deep neural networks (DNNs) have shown a strong capacity to solve large-scale problems in many areas, such DNNs are hard to be deployed in real-world systems due to their voluminous parameters. To tackle this issue, Teacher-Student architectures were proposed, where simple student networks with a few parameters can achieve comparable performance to deep teacher networks with many parameters. Recently, Teacher-Student architectures have been effectively and widely embraced on various knowledge distillation (KD) objectives, including knowledge compression, knowledge expansion, knowledge adaptation, and knowledge enhancement. With the help of Teacher-Student architectures, current studies are able to achieve multiple distillation objectives through lightweight and generalized student networks. Different from existing KD surveys that primarily focus on knowledge compression, this survey first explores Teacher-Student architectures across multiple distillation objectives. This survey presents an introduction to various knowledge representations and their corresponding optimization objectives. Additionally, we provide a systematic overview of Teacher-Student architectures with representative learning algorithms and effective distillation schemes. This survey also summarizes recent applications of Teacher-Student architectures across multiple purposes, including classification, recognition, generation, ranking, and regression. Lastly, potential research directions in KD are investigated, focusing on architecture design, knowledge quality, and theoretical studies of regression-based learning, respectively. Through this comprehensive survey, industry practitioners and the academic community can gain valuable insights and guidelines for effectively designing, learning, and applying Teacher-Student architectures on various distillation objectives.

T o address this problem, BSs can work collaboratively to deliver a smooth migration (or handoff) and satisfy the UEs' service requirements. This paper formulates the load balancing problem as a Markov game and proposes a Robust Multi-agent Attention Actor-Critic (Robust-MA3C) algorithm that can facilitate collaboration among the BSs (i.e., agents). In particular, to solve the Markov game and find a Nash equilibrium policy, we embrace the idea of adopting a nature agent to model the system uncertainty. Moreover, we utilize the self-attention mechanism, which encourages high-performance BSs to assist low-performance BSs. In addition, we consider two types of schemes, which can facilitate load balancing for both active UEs and idle UEs. We carry out extensive evaluations by simulations, and simulation results illustrate that, compared to the state-of-the-art MARL methods, Robust-MA3C scheme can improve the overall performance by up to 45%.

The AlphaFold computer program predicted protein structures for the whole human genome, which has been considered as a remarkable breakthrough both in artificial intelligence (AI) application and structural biology. Despite the varying confidence level, these predicted structures still could significantly contribute to structure-based drug design of novel targets, especially the ones with no or limited structural information. In this work, we successfully applied AlphaFold in our end-to-end AI-powered drug discovery engines constituted of a biocomputational platform PandaOmics and a generative chemistry platform Chemistry42, to identify a first-in-class hit molecule of a novel target without an experimental structure starting from target selection towards hit identification in a cost- and time-efficient manner. PandaOmics provided the targets of interest and Chemistry42 generated the molecules based on the AlphaFold predicted structure, and the selected molecules were synthesized and tested in biological assays. Through this approach, we identified a small molecule hit compound for CDK20 with a Kd value of 8.9 +/- 1.6 uM (n = 4) within 30 days from target selection and after only synthesizing 7 compounds. Based on the available data, the second round of AI-powered compound generation was conducted and through which, a more potent hit molecule, ISM042-2 048, was discovered with a Kd value of 210.0 +/- 42.4 nM (n = 2), within 30 days and after synthesizing 6 compounds from the discovery of the first hit ISM042-2-001. To the best of our knowledge, this is the first reported small molecule targeting CDK20 and more importantly, this work is the first demonstration of AlphaFold application in the hit identification process in early drug discovery.

We report the design and implement of a land robot whose primary task is to “patch” a Wireless Sensor Network. the Tekkotsu/Create system is modified to support GPS-guided navigation and radio-sensing based navigation . The project is a moderate success with both GPS and radio-sensing navigation algorithms achieve similar navigation performance.