The genes in nature give the lives on earth the current biological intelligence through transmission and accumulation over billions of years. Inspired by the biological intelligence, artificial intelligence (AI) has devoted to building the machine intelligence. Although it has achieved thriving successes, the machine intelligence still lags far behind the biological intelligence. The reason may lie in that animals are born with some intelligence encoded in their genes, but machines lack such intelligence and learn from scratch. Inspired by the genes of animals, we define the ``genes'' of machines named as the ``learngenes'' and propose the Genetic Reinforcement Learning (GRL). GRL is a computational framework that simulates the evolution of organisms in reinforcement learning (RL) and leverages the learngenes to learn and evolve the intelligence agents. Leveraging GRL, we first show that the learngenes take the form of the fragments of the agents' neural networks and can be inherited across generations. Second, we validate that the learngenes can transfer ancestral experience to the agents and bring them instincts and strong learning abilities. Third, we justify the Lamarckian inheritance of the intelligent agents and the continuous evolution of the learngenes. Overall, the learngenes have taken the machine intelligence one more step toward the biological intelligence.

Social networks represent a common form of interconnected data frequently depicted as graphs within the domain of deep learning-based inference. These communities inherently form dynamic systems, achieving stability through continuous internal communications and opinion exchanges among social actors along their social ties. In contrast, neural message passing in deep learning provides a clear and intuitive mathematical framework for understanding information propagation and aggregation among connected nodes in graphs. Node representations are dynamically updated by considering both the connectivity and status of neighboring nodes. This research harmonizes concepts from sociometry and neural message passing to analyze and infer the behavior of dynamic systems. Drawing inspiration from opinion dynamics in sociology, we propose ODNet, a novel message passing scheme incorporating bounded confidence, to refine the influence weight of local nodes for message propagation. We adjust the similarity cutoffs of bounded confidence and influence weights of ODNet and define opinion exchange rules that align with the characteristics of social network graphs. We show that ODNet enhances prediction performance across various graph types and alleviates oversmoothing issues. Furthermore, our approach surpasses conventional baselines in graph representation learning and proves its practical significance in analyzing real-world co-occurrence networks of metabolic genes. Remarkably, our method simplifies complex social network graphs solely by leveraging knowledge of interaction frequencies among entities within the system. It accurately identifies internal communities and the roles of genes in different metabolic pathways, including opinion leaders, bridge communicators, and isolators.

Language models contain ranking-based knowledge and are powerful solvers of in-context ranking tasks. For instance, they may have parametric knowledge about the ordering of countries by size or may be able to rank reviews by sentiment. Recent work focuses on pairwise, pointwise, and listwise prompting techniques to elicit a language model's ranking knowledge. However, we find that even with careful calibration and constrained decoding, prompting-based techniques may not always be self-consistent in the rankings they produce. This motivates us to explore an alternative approach that is inspired by an unsupervised probing method called Contrast-Consistent Search (CCS). The idea is to train a probing model guided by a logical constraint: a model's representation of a statement and its negation must be mapped to contrastive true-false poles consistently across multiple statements. We hypothesize that similar constraints apply to ranking tasks where all items are related via consistent pairwise or listwise comparisons. To this end, we extend the binary CCS method to Contrast-Consistent Ranking (CCR) by adapting existing ranking methods such as the Max-Margin Loss, Triplet Loss, and Ordinal Regression objective. Our results confirm that, for the same language model, CCR probing outperforms prompting and even performs on a par with prompting much larger language models.

Objectives: Approximately 30% of non-metastatic anal squamous cell carcinoma (ASCC) patients will experience recurrence after chemoradiotherapy (CRT), and currently available clinical variables are poor predictors of treatment response. We aimed to develop a model leveraging information extracted from radiation pretreatment planning CT to predict recurrence-free survival (RFS) in ASCC patients after CRT. Methods: Radiomics features were extracted from planning CT images of 96 ASCC patients. Following pre-feature selection, the optimal feature set was selected via step-forward feature selection with a multivariate Cox proportional hazard model. The RFS prediction was generated from a radiomics-clinical combined model based on an optimal feature set with five repeats of five-fold cross validation. The risk stratification ability of the proposed model was evaluated with Kaplan-Meier analysis. Results: Shape- and texture-based radiomics features significantly predicted RFS. Compared to a clinical-only model, radiomics-clinical combined model achieves better performance in the testing cohort with higher C-index (0.80 vs 0.73) and AUC (0.84 vs 0.79 for 1-year RFS, 0.84 vs 0.78 for 2-year RFS, and 0.86 vs 0.83 for 3-year RFS), leading to distinctive high- and low-risk of recurrence groups (p<0.001). Conclusions: A treatment planning CT based radiomics and clinical combined model had improved prognostic performance in predicting RFS for ASCC patients treated with CRT as compared to a model using clinical features only.

Label distribution learning (LDL) trains a model to predict the relevance of a set of labels (called label distribution (LD)) to an instance. The previous LDL methods all assumed the LDs of the training instances are accurate. However, annotating highly accurate LDs for training instances is time-consuming and very expensive, and in reality the collected LD is usually inaccurate and disturbed by annotating errors. For the first time, this paper investigates the problem of inaccurate LDL, i.e., developing an LDL model with noisy LDs. We assume that the noisy LD matrix is a linear combination of an ideal LD matrix and a sparse noise matrix. Consequently, the problem of inaccurate LDL becomes an inverse problem, where the objective is to recover the ideal LD and noise matrices from the noisy LDs. We hypothesize that the ideal LD matrix is low-rank due to the correlation of labels and utilize the local geometric structure of instances captured by a graph to assist in recovering the ideal LD. This is based on the premise that similar instances are likely to share the same LD. The proposed model is finally formulated as a graph-regularized low-rank and sparse decomposition problem and numerically solved by the alternating direction method of multipliers. Furthermore, a specialized objective function is utilized to induce a LD predictive model in LDL, taking into account the recovered label distributions. Extensive experiments conducted on multiple datasets from various real-world tasks effectively demonstrate the efficacy of the proposed approach. \end{abstract}

The application of video captioning models aims at translating the content of videos by using accurate natural language. Due to the complex nature inbetween object interaction in the video, the comprehensive understanding of spatio-temporal relations of objects remains a challenging task. Existing methods often fail in generating sufficient feature representations of video content. In this paper, we propose a video captioning model based on dual graphs and gated fusion: we adapt two types of graphs to generate feature representations of video content and utilize gated fusion to further understand these different levels of information. Using a dual-graphs model to generate appearance features and motion features respectively can utilize the content correlation in frames to generate various features from multiple perspectives. Among them, dual-graphs reasoning can enhance the content correlation in frame sequences to generate advanced semantic features; The gated fusion, on the other hand, aggregates the information in multiple feature representations for comprehensive video content understanding. The experiments conducted on worldly used datasets MSVD and MSR-VTT demonstrate state-of-the-art performance of our proposed approach.

Transformer-based pretrained language models (PLMs) have achieved great success in modern NLP. An important advantage of PLMs is good out-of-distribution (OOD) robustness. Recently, diffusion models have attracted a lot of work to apply diffusion to PLMs. It remains under-explored how diffusion influences PLMs on OOD data. The core of diffusion models is a forward diffusion process which gradually applies Gaussian noise to inputs, and a reverse denoising process which removes noise. The noised input reconstruction is a fundamental ability of diffusion models. We directly analyze OOD robustness by measuring the reconstruction loss, including testing the abilities to reconstruct OOD data, and to detect OOD samples. Experiments are conducted by analyzing different training parameters and data statistical features on eight datasets. It shows that finetuning PLMs with diffusion degrades the reconstruction ability on OOD data. The comparison also shows that diffusion models can effectively detect OOD samples, achieving state-of-the-art performance in most of the datasets with an absolute accuracy improvement up to 18%. These results indicate that diffusion reduces OOD robustness of PLMs.

During the continuous evolution of one organism's ancestry, its genes accumulate extensive experiences and knowledge, enabling newborn descendants to rapidly adapt to their specific environments. Motivated by this observation, we propose a novel machine learning paradigm Learngene to enable learning models to incorporate three key characteristics of genes. (i) Accumulating: the knowledge is accumulated during the continuous learning of an ancestry model. (ii) Condensing: the extensive accumulated knowledge is condensed into a much more compact information piece, i.e., learngene. (iii) Inheriting: the condensed learngene is inherited to make it easier for descendant models to adapt to new environments. Since accumulating has been studied in well-established paradigms like large-scale pre-training and lifelong learning, we focus on condensing and inheriting, which induces three key issues and we provide the preliminary solutions to these issues in this paper: (i) Learngene Form: the learngene is set to a few integral layers that can preserve significance. (ii) Learngene Condensing: we identify which layers among the ancestry model have the most similarity as one pseudo descendant model. (iii) Learngene Inheriting: to construct distinct descendant models for the specific downstream tasks, we stack some randomly initialized layers to the learngene layers. Extensive experiments across various settings, including using different network architectures like Vision Transformer (ViT) and Convolutional Neural Networks (CNNs) on different datasets, are carried out to confirm four advantages of Learngene: it makes the descendant models 1) converge more quickly, 2) exhibit less sensitivity to hyperparameters, 3) perform better, and 4) require fewer training samples to converge.

Food effect summarization from New Drug Application (NDA) is an essential component of product-specific guidance (PSG) development and assessment. However, manual summarization of food effect from extensive drug application review documents is time-consuming, which arouses a need to develop automated methods. Recent advances in large language models (LLMs) such as ChatGPT and GPT-4, have demonstrated great potential in improving the effectiveness of automated text summarization, but its ability regarding the accuracy in summarizing food effect for PSG assessment remains unclear. In this study, we introduce a simple yet effective approach, iterative prompting, which allows one to interact with ChatGPT or GPT-4 more effectively and efficiently through multi-turn interaction. Specifically, we propose a three-turn iterative prompting approach to food effect summarization in which the keyword-focused and length-controlled prompts are respectively provided in consecutive turns to refine the quality of the generated summary. We conduct a series of extensive evaluations, ranging from automated metrics to FDA professionals and even evaluation by GPT-4, on 100 NDA review documents selected over the past five years. We observe that the summary quality is progressively improved throughout the process. Moreover, we find that GPT-4 performs better than ChatGPT, as evaluated by FDA professionals (43% vs. 12%) and GPT-4 (64% vs. 35%). Importantly, all the FDA professionals unanimously rated that 85% of the summaries generated by GPT-4 are factually consistent with the golden reference summary, a finding further supported by GPT-4 rating of 72% consistency. These results strongly suggest a great potential for GPT-4 to draft food effect summaries that could be reviewed by FDA professionals, thereby improving the efficiency of PSG assessment cycle and promoting the generic drug product development.

Automatic bill payment is an important part of business operations in fintech companies. The practice of deduction was mainly based on the total amount or heuristic search by dividing the bill into smaller parts to deduct as much as possible. This article proposes an end-to-end approach of automatically learning the optimal deduction paths (deduction amount in order), which reduces the cost of manual path design and maximizes the amount of successful deduction. Specifically, in view of the large search space of the paths and the extreme sparsity of historical successful deduction records, we propose a deep hierarchical reinforcement learning approach which abstracts the action into a two-level hierarchical space: an upper agent that determines the number of steps of deductions each day and a lower agent that decides the amount of deduction at each step. In such a way, the action space is structured via prior knowledge and the exploration space is reduced. Moreover, the inherited information incompleteness of the business makes the environment just partially observable. To be precise, the deducted amounts indicate merely the lower bounds of the available account balance. To this end, we formulate the problem as a partially observable Markov decision problem (POMDP) and employ an environment correction algorithm based on the characteristics of the business. In the world's largest electronic payment business, we have verified the effectiveness of this scheme offline and deployed it online to serve millions of users.