Large language models (LLMs) demonstrate exceptional instruct-following ability to complete various downstream tasks. Although this impressive ability makes LLMs flexible task solvers, their performance in solving tasks also heavily relies on instructions. In this paper, we reveal that LLMs are over-sensitive to lexical variations in task instructions, even when the variations are imperceptible to humans. By providing models with neighborhood instructions, which are closely situated in the latent representation space and differ by only one semantically similar word, the performance on downstream tasks can be vastly different. Following this property, we propose a black-box Combinatorial Optimization framework for Prompt Lexical Enhancement (COPLE). COPLE performs iterative lexical optimization according to the feedback from a batch of proxy tasks, using a search strategy related to word influence. Experiments show that even widely-used human-crafted prompts for current benchmarks suffer from the lexical sensitivity of models, and COPLE recovers the declined model ability in both instruct-following and solving downstream tasks.

Large language models (LLMs) have made impressive progress in chemistry applications, including molecular property prediction, molecular generation, experimental protocol design, etc. However, the community lacks a dialogue-based model specifically designed for chemistry. The challenge arises from the fact that most chemical data and scientific knowledge are primarily stored in structured databases, and the direct use of these structured data compromises the model's ability to maintain coherent dialogue. To tackle this issue, we develop a novel template-based instruction construction method that transforms structured knowledge into plain dialogue, making it suitable for language model training. By leveraging this approach, we develop ChemLLM, the first large language model dedicated to chemistry, capable of performing various tasks across chemical disciplines with smooth dialogue interaction. ChemLLM beats GPT-3.5 on all three principal tasks in chemistry, i.e., name conversion, molecular caption, and reaction prediction, and surpasses GPT-4 on two of them. Remarkably, ChemLLM also shows exceptional adaptability to related mathematical and physical tasks despite being trained mainly on chemical-centric corpora. Furthermore, ChemLLM demonstrates proficiency in specialized NLP tasks within chemistry, such as literature translation and cheminformatic programming. ChemLLM opens up a new avenue for exploration within chemical studies, while our method of integrating structured chemical knowledge into dialogue systems sets a new frontier for developing LLMs across various scientific fields. Codes, Datasets, and Model weights are publicly accessible at hf.co/AI4Chem/ChemLLM-7B-Chat.