Clinical trials are a critical process in the medical field for introducing new treatments and innovations. However, cohort selection for clinical trials is a time-consuming process that often requires manual review of patient text records for specific keywords. Though there have been studies on standardizing the information across the various platforms, Natural Language Processing (NLP) tools remain crucial for spotting eligibility criteria in textual reports. Recently, pre-trained large language models (LLMs) have gained popularity for various NLP tasks due to their ability to acquire a nuanced understanding of text. In this paper, we study the performance of large language models on clinical trial cohort selection and leverage the n2c2 challenges to benchmark their performance. Our results are promising with regard to the incorporation of LLMs for simple cohort selection tasks, but also highlight the difficulties encountered by these models as soon as fine-grained knowledge and reasoning are required.

In the United States, prostate cancer is the second leading cause of deaths in males with a predicted 35,250 deaths in 2024. However, most diagnoses are non-lethal and deemed clinically insignificant which means that the patient will likely not be impacted by the cancer over their lifetime. As a result, numerous research studies have explored the accuracy of predicting clinical significance of prostate cancer based on magnetic resonance imaging (MRI) modalities and deep neural networks. Despite their high performance, these models are not trusted by most clinical scientists as they are trained solely on a single modality whereas clinical scientists often use multiple magnetic resonance imaging modalities during their diagnosis. In this paper, we investigate combining multiple MRI modalities to train a deep learning model to enhance trust in the models for clinically significant prostate cancer prediction. The promising performance and proposed training pipeline showcase the benefits of incorporating multiple MRI modalities for enhanced trust and accuracy.

In the United States, skin cancer ranks as the most commonly diagnosed cancer, presenting a significant public health issue due to its high rates of occurrence and the risk of serious complications if not caught early. Recent advancements in dataset curation and deep learning have shown promise in quick and accurate detection of skin cancer. However, current open-source datasets have significant class imbalances which impedes the effectiveness of these deep learning models. In healthcare, generative artificial intelligence (AI) models have been employed to create synthetic data, addressing data imbalance in datasets by augmenting underrepresented classes and enhancing the overall quality and performance of machine learning models. In this paper, we build on top of previous work by leveraging new advancements in generative AI, notably Stable Diffusion and DreamBooth. We introduce Cancer-Net SCa-Synth, an open access synthetically generated 2D skin lesion dataset for skin cancer classification. Further analysis on the data effectiveness by comparing the ISIC 2020 test set performance for training with and without these synthetic images for a simple model highlights the benefits of leveraging synthetic data to improve performance.

Accurate dietary intake estimation is critical for informing policies and programs to support healthy eating, as malnutrition has been directly linked to decreased quality of life. However self-reporting methods such as food diaries suffer from substantial bias. Other conventional dietary assessment techniques and emerging alternative approaches such as mobile applications incur high time costs and may necessitate trained personnel. Recent work has focused on using computer vision and machine learning to automatically estimate dietary intake from food images, but the lack of comprehensive datasets with diverse viewpoints, modalities and food annotations hinders the accuracy and realism of such methods. To address this limitation, we introduce NutritionVerse-Synth, the first large-scale dataset of 84,984 photorealistic synthetic 2D food images with associated dietary information and multimodal annotations (including depth images, instance masks, and semantic masks). Additionally, we collect a real image dataset, NutritionVerse-Real, containing 889 images of 251 dishes to evaluate realism. Leveraging these novel datasets, we develop and benchmark NutritionVerse, an empirical study of various dietary intake estimation approaches, including indirect segmentation-based and direct prediction networks. We further fine-tune models pretrained on synthetic data with real images to provide insights into the fusion of synthetic and real data. Finally, we release both datasets (NutritionVerse-Synth, NutritionVerse-Real) on https://www.kaggle.com/nutritionverse/datasets as part of an open initiative to accelerate machine learning for dietary sensing.