Brain-Machine Interfaces (BMIs) have recently emerged as a clinically viable option to restore voluntary movements after paralysis. These devices are based on the ability to extract information about movement intent from neural signals recorded using multi-electrode arrays chronically implanted in the motor cortices of the brain. However, the inherent loss and turnover of recorded neurons requires repeated recalibrations of the interface, which can potentially alter the day-to-day user experience. The resulting need for continued user adaptation interferes with the natural, subconscious use of the BMI. Here, we introduce a new computational approach that decodes movement intent from a low-dimensional latent representation of the neural data. We implement various domain adaptation methods to stabilize the interface over significantly long times. This includes Canonical Correlation Analysis used to align the latent variables across days; this method requires prior point-to-point correspondence of the time series across domains. Alternatively, we match the empirical probability distributions of the latent variables across days through the minimization of their Kullback-Leibler divergence. These two methods provide a significant and comparable improvement in the performance of the interface. However, implementation of an Adversarial Domain Adaptation Network trained to match the empirical probability distribution of the residuals of the reconstructed neural signals outperforms the two methods based on latent variables, while requiring remarkably few data points to solve the domain adaptation problem.

Dopamine exerts two classes of effect on the sustained neural activity in prefrontal cortex that underlies working memory. Direct release in the cortex increases the contrast of prefrontal neurons, enhancing the robustness of storage. Release of dopamine in the striatum is associated with salient stimuli and makes medium spiny neurons bistable; this modulation of the output of spiny neurons affects prefrontal cortex so as to indirectly gate access to working memory and additionally damp sensitivity to noise. Existing models have treated dopamine in one or other structure, or have addressed basal ganglia gating of working memory exclusive of dopamine effects. In this paper we combine these mechanisms and explore their joint effect. We model a memory-guided saccade task to illustrate how dopamine's actions lead to working memory that is selective for salient input and has increased robustness to distraction.

Dopamine exerts two classes of effect on the sustained neural activity in prefrontal cortex that underlies working memory. Direct release in the cortex increases the contrast of prefrontal neurons, enhancing the robustness ofstorage. Release of dopamine in the striatum is associated with salient stimuli and makes medium spiny neurons bistable; this modulation ofthe output of spiny neurons affects prefrontal cortex so as to indirectly gate access to working memory and additionally damp sensitivity tonoise. Existing models have treated dopamine in one or other structure, or have addressed basal ganglia gating of working memory exclusive ofdopamine effects. In this paper we combine these mechanisms and explore their joint effect. We model a memory-guided saccade task to illustrate how dopamine's actions lead to working memory that is selective forsalient input and has increased robustness to distraction.

Single unit activity in the striatum of awake monkeys shows a marked dependence on the expected reward that a behavior will elicit. We present a computational model of spiny neurons, the principal neurons of the striatum, to assess the hypothesis that direct neuromodulatory effects of dopamine through the activation of D 1 receptors mediate the reward dependency of spiny neuron activity. Dopamine release results in the amplification of key ion currents, leading to the emergence of bistability, which not only modulates the peak firing rate but also introduces a temporal and state dependence of the model's response, thus improving the detectability of temporally correlated inputs. 1 Introduction The classic notion of the basal ganglia as being involved in purely motor processing has expanded over the years to include sensory and cognitive functions. A surprising new finding is that much of this activity shows a motivational component. For instance, striatal activity related to visual stimuli is dependent on the type of reinforcement (primary vs secondary) that a behavior will elicit [1].

Single unit activity in the striatum of awake monkeys shows a marked dependence on the expected reward that a behavior will elicit. We present a computational model of spiny neurons, the principal neurons of the striatum, to assess the hypothesis that direct neuromodulatoryeffects of dopamine through the activation of D1 receptors mediate the reward dependency of spiny neuron activity. Dopamine release results in the amplification of key ion currents, leading to the emergence of bistability, which not only modulates the peak firing rate but also introduces a temporal and state dependence of the model's response, thus improving the detectability oftemporally correlated inputs. 1 Introduction The classic notion of the basal ganglia as being involved in purely motor processing has expanded over the years to include sensory and cognitive functions. A surprising newfinding is that much of this activity shows a motivational component. For instance, striatal activity related to visual stimuli is dependent on the type of reinforcement (primary vs secondary) that a behavior will elicit [1].

We study the effect of noise and regularization in an online gradient-descent learning scenario for a general two-layer student network with an arbitrary number of hidden units. Training examples are randomly drawn input vectors labeled by a two-layer teacher network with an arbitrary number of hidden units; the examples are corrupted by Gaussian noise affecting either the output or the model itself. We examine the effect of both types of noise and that of weight-decay regularization on the dynamical evolution of the order parameters and the generalization error in various phases of the learning process.

We study the effect of noise and regularization in an online gradient-descent learning scenario for a general two-layer student network with an arbitrary number of hidden units. Training examples arerandomly drawn input vectors labeled by a two-layer teacher network with an arbitrary number of hidden units; the examples arecorrupted by Gaussian noise affecting either the output or the model itself. We examine the effect of both types of noise and that of weight-decay regularization on the dynamical evolution ofthe order parameters and the generalization error in various phases of the learning process. 1 Introduction One of the most powerful and commonly used methods for training large layered neural networks is that of online learning, whereby the internal network parameters {J} are modified after the presentation of each training example so as to minimize the corresponding error.

Sollat CONNECT, The Niels Bohr Institute Blegdamsdvej 17 Copenhagen 2100, Denmark Abstract We consider the problem of online gradient descent learning for general two-layer neural networks. An analytic solution is presented andused to investigate the role of the learning rate in controlling theevolution and convergence of the learning process. Two-layer networks with an arbitrary number of hidden units have been shown to be universal approximators [1] for such N-to-one dimensional maps. We investigate the emergence of generalization ability in an online learning scenario [2], in which the couplings are modified after the presentation of each example so as to minimize the corresponding error. The resulting changes in {J} are described as a dynamical evolution; the number of examples plays the role of time.

We consider the problem of online gradient descent learning for general two-layer neural networks. An analytic solution is presented and used to investigate the role of the learning rate in controlling the evolution and convergence of the learning process. Two-layer networks with an arbitrary number of hidden units have been shown to be universal approximators [1] for such N-to-one dimensional maps. We investigate the emergence of generalization ability in an online learning scenario [2], in which the couplings are modified after the presentation of each example so as to minimize the corresponding error. The resulting changes in {J} are described as a dynamical evolution; the number of examples plays the role of time.

Training classifiers on large databases is computationally demanding. It is desirable to develop efficient procedures for a reliable prediction of a classifier's suitability for implementing a given task, so that resources can be assigned to the most promising candidates or freed for exploring new classifier candidates. We propose such a practical and principled predictive method. Practical because it avoids the costly procedure of training poor classifiers on the whole training set, and principled because of its theoretical foundation. The effectiveness of the proposed procedure is demonstrated for both single-and multi-layer networks.