Deep learning has demonstrated remarkable achievements in medical image segmentation. However, prevailing deep learning models struggle with poor generalization due to (i) intra-class variations, where the same class appears differently in different samples, and (ii) inter-class independence, resulting in difficulties capturing intricate relationships between distinct objects, leading to higher false negative cases. This paper presents a novel approach that synergies spatial and spectral representations to enhance domain-generalized medical image segmentation. We introduce the innovative Spectral Correlation Coefficient objective to improve the model's capacity to capture middle-order features and contextual long-range dependencies. This objective complements traditional spatial objectives by incorporating valuable spectral information. Extensive experiments reveal that optimizing this objective with existing architectures like UNet and TransUNet significantly enhances generalization, interpretability, and noise robustness, producing more confident predictions. For instance, in cardiac segmentation, we observe a 0.81 pp and 1.63 pp (pp = percentage point) improvement in DSC over UNet and TransUNet, respectively. Our interpretability study demonstrates that, in most tasks, objectives optimized with UNet outperform even TransUNet by introducing global contextual information alongside local details. These findings underscore the versatility and effectiveness of our proposed method across diverse imaging modalities and medical domains.

In this paper, we present iPrescribe, a scalable low-latency architecture for recommending 'next-best-offers' in an online setting. The paper presents the design of iPrescribe and compares its performance for implementations using different real-time streaming technology stacks. iPrescribe uses an ensemble of deep learning and machine learning algorithms for prediction. We describe the scalable real-time streaming technology stack and optimized machine-learning implementations to achieve a 90th percentile recommendation latency of 38 milliseconds. Optimizations include a novel mechanism to deploy recurrent Long Short Term Memory (LSTM) deep learning networks efficiently.