Fine-tuning pre-trained Large Language Models (LLMs) for downstream tasks using First-Order (FO) optimizers presents significant computational challenges. Parameter-Efficient Fine-Tuning(PEFT) methods have been proposed to address these challenges by freezing most model parameters and training only a small subset. While PEFT is efficient, it may not outperform full fine-tuning when high task-specific performance is required. Zeroth-Order (ZO) methods offer an alternative for fine-tuning the entire pre-trained model by approximating gradients using only the forward pass, thus eliminating the computational burden of back-propagation in first-order methods. However, when implementing ZO methods, a hard prompt is crucial, and relying on simple, fixed hard prompts may not be optimal. In this paper, we propose a bilevel optimization framework that complements ZO methods with PEFT to mitigate sensitivity to hard prompts while efficiently and effectively fine-tuning LLMs. Our Bilevel ZOFO (Zeroth-Order-First-Order) method employs a double-loop optimization strategy, where only the gradient of the PEFT model and the forward pass of the base model are required. We provide convergence guarantees for Bilevel ZOFO. Empirically, we demonstrate that Bilevel ZOFO outperforms both PEFT and ZO methods in single-task settings while maintaining similar memory efficiency. Additionally, we show its strong potential for multitask learning. Compared to current first-order meta-training algorithms for multitask learning, our method has significantly lower computational demands while maintaining or improving performance.

Large Language Models (LLMs) have demonstrated remarkable abilities in tackling a wide range of complex tasks. However, their huge computational and memory costs raise significant challenges in deploying these models on resource-constrained devices or efficiently serving them. Prior approaches have attempted to alleviate these problems by permanently removing less important model structures, yet these methods often result in substantial performance degradation due to the permanent deletion of model parameters. In this work, we tried to mitigate this issue by reducing the number of active parameters without permanently removing them. Specifically, we introduce a differentiable dynamic pruning method that pushes dense models to maintain a fixed number of active parameters by converting their MLP layers into a Mixture of Experts (MoE) architecture. Our method, even without fine-tuning, consistently outperforms previous structural pruning techniques across diverse model families, including Phi-2, LLaMA-2, LLaMA-3, and Qwen-2.5.

Recent advances in diffusion generative models have yielded remarkable progress. While the quality of generated content continues to improve, these models have grown considerably in size and complexity. This increasing computational burden poses significant challenges, particularly in resource-constrained deployment scenarios such as mobile devices. The combination of model pruning and knowledge distillation has emerged as a promising solution to reduce computational demands while preserving generation quality. However, this technique inadvertently propagates undesirable behaviors, including the generation of copyrighted content and unsafe concepts, even when such instances are absent from the fine-tuning dataset. In this paper, we propose a novel bilevel optimization framework for pruned diffusion models that consolidates the fine-tuning and unlearning processes into a unified phase. Our approach maintains the principal advantages of distillation-namely, efficient convergence and style transfer capabilities-while selectively suppressing the generation of unwanted content. This plug-in framework is compatible with various pruning and concept unlearning methods, facilitating efficient, safe deployment of diffusion models in controlled environments.

Graph transformers have gained popularity in various graph-based tasks by addressing challenges faced by traditional Graph Neural Networks. However, the quadratic complexity of self-attention operations and the extensive layering in graph transformer architectures present challenges when applying them to graph based prediction tasks. Fine-tuning, a common approach, is resource-intensive and requires storing multiple copies of large models. We propose a novel approach called deep graph prompt tuning as an alternative to fine-tuning for leveraging large graph transformer models in downstream graph based prediction tasks. Our method introduces trainable feature nodes to the graph and pre-pends task-specific tokens to the graph transformer, enhancing the model's expressive power. By freezing the pre-trained parameters and only updating the added tokens, our approach reduces the number of free parameters and eliminates the need for multiple model copies, making it suitable for small datasets and scalable to large graphs. Through extensive experiments on various-sized datasets, we demonstrate that deep graph prompt tuning achieves comparable or even superior performance to fine-tuning, despite utilizing significantly fewer task-specific parameters. Our contributions include the introduction of prompt tuning for graph transformers, its application to both graph transformers and message passing graph neural networks, improved efficiency and resource utilization, and compelling experimental results. This work brings attention to a promising approach to leverage pre-trained models in graph based prediction tasks and offers new opportunities for exploring and advancing graph representation learning.

Postoperative complications pose a significant challenge in the healthcare industry, resulting in elevated healthcare expenses and prolonged hospital stays, and in rare instances, patient mortality. To improve patient outcomes and reduce healthcare costs, healthcare providers rely on various perioperative risk scores to guide clinical decisions and prioritize care. In recent years, machine learning techniques have shown promise in predicting postoperative complications and fatality, with deep learning models achieving remarkable success in healthcare applications. However, research on the application of deep learning models to intra-operative anesthesia management data is limited. In this paper, we evaluate the performance of transformer-based models in predicting postoperative acute renal failure, postoperative pulmonary complications, and postoperative in-hospital mortality. We compare our method's performance with state-of-the-art tabular data prediction models, including gradient boosting trees and sequential attention models, on a clinical dataset. Our results demonstrate that transformer-based models can achieve superior performance in predicting postoperative complications and outperform traditional machine learning models. This work highlights the potential of deep learning techniques, specifically transformer-based models, in revolutionizing the healthcare industry's approach to postoperative care.

Recent advancements in the acquisition of various brain data sources have created new opportunities for integrating multimodal brain data to assist in early detection of complex brain disorders. However, current data integration approaches typically need a complete set of biomedical data modalities, which may not always be feasible, as some modalities are only available in large-scale research cohorts and are prohibitive to collect in routine clinical practice. Especially in studies of brain diseases, research cohorts may include both neuroimaging data and genetic data, but for practical clinical diagnosis, we often need to make disease predictions only based on neuroimages. As a result, it is desired to design machine learning models which can use all available data (different data could provide complementary information) during training but conduct inference using only the most common data modality. We propose a new incomplete multimodal data integration approach that employs transformers and generative adversarial networks to effectively exploit auxiliary modalities available during training in order to improve the performance of a unimodal model at inference. We apply our new method to predict cognitive degeneration and disease outcomes using the multimodal imaging genetic data from Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Experimental results demonstrate that our approach outperforms the related machine learning and deep learning methods by a significant margin.