Commonsense temporal reasoning at scale is a core problem for cognitive systems. The correct inference of the duration for which fluents hold is required by many tasks, including natural language understanding and planning. Many AI systems have limited deductive closure because they cannot extrapolate information correctly regarding existing fluents and events. In this study, we discuss the knowledge representation and reasoning schemes required for robust temporal projection in the Cyc Knowledge Base. We discuss how events can start and end risk periods for fluents. We then use discrete survival functions, which represent knowledge of the persistence of facts, to extrapolate a given fluent. The extrapolated intervals can be truncated by temporal constraints and other types of commonsense knowledge. Finally, we present the results of experiments to demonstrate that these methods obtain significant improvements in terms of Q/A performance.

Recent progress in Learning by Reading and Machine Reading systems has significantly increased the capacity of knowledge-based systems to learn new facts. In this work, we discuss the problem of selecting a set of learning requests for these knowledge-based systems which would lead to maximum Q/A performance. To understand the dynamics of this problem, we simulate the properties of a learning strategy, which sends learning requests to an external knowledge source. We show that choosing an optimal set of facts for these learning systems is similar to a coordination game, and use reinforcement learning to solve this problem. Experiments show that such an approach can significantly improve Q/A performance.

What properties of a first-order search space support/hinder inference? What kinds of facts would be most effective to learn? Answering these questions is essential for understanding the dynamics of deductive reasoning and creating large-scale knowledge-based learning systems that support efficient inference. We address these questions by developing a model of how the distribution of ground facts affects inference performance in search spaces. Experiments suggest that uniform search spaces are suitable for larger KBs whereas search spaces with skewed degree distribution show better performance in smaller KBs. A sharp transition in Q/A performance is seen in some cases, suggesting that analysis of the structure of search spaces with existing knowledge should be used to guide the acquisition of new ground facts in learning systems.

Parkinson's Disease (PD) is a degenerative neurological disorder that impairs motor and non-motor functions, significantly reducing quality of life and increasing mortality risk. Early and accurate detection of PD progression is vital for effective management and improved patient outcomes. Current diagnostic methods, however, are often costly, time-consuming, and require specialized equipment and expertise. This work proposes an innovative approach to predicting PD progression using regression methods, Long Short-Term Memory (LSTM) networks, and Kolmogorov Arnold Networks (KAN). KAN, utilizing spline-parametrized univariate functions, allows for dynamic learning of activation patterns, unlike traditional linear models. The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a comprehensive tool for evaluating PD symptoms and is commonly used to measure disease progression. Additionally, protein or peptide abnormalities are linked to PD onset and progression. Identifying these associations can aid in predicting disease progression and understanding molecular changes. Comparing multiple models, including LSTM and KAN, this study aims to identify the method that delivers the highest metrics. The analysis reveals that KAN, with its dynamic learning capabilities, outperforms other approaches in predicting PD progression. This research highlights the potential of AI and machine learning in healthcare, paving the way for advanced computational models to enhance clinical predictions and improve patient care and treatment strategies in PD management.

Inflammation of the umbilical cord can be seen as a result of ascending intrauterine infection or other inflammatory stimuli. Acute fetal inflammatory response (FIR) is characterized by infiltration of the umbilical cord by fetal neutrophils, and can be associated with neonatal sepsis or fetal inflammatory response syndrome. Recent advances in deep learning in digital pathology have demonstrated favorable performance across a wide range of clinical tasks, such as diagnosis and prognosis. In this study we classified FIR from whole slide images (WSI). We digitized 4100 histological slides of umbilical cord stained with hematoxylin and eosin(H&E) and extracted placental diagnoses from the electronic health record. We build models using attention-based whole slide learning models. We compared strategies between features extracted by a model (ConvNeXtXLarge) pretrained on non-medical images (ImageNet), and one pretrained using histopathology images (UNI). We trained multiple iterations of each model and combined them into an ensemble. The predictions from the ensemble of models trained using UNI achieved an overall balanced accuracy of 0.836 on the test dataset. In comparison, the ensembled predictions using ConvNeXtXLarge had a lower balanced accuracy of 0.7209. Heatmaps generated from top accuracy model appropriately highlighted arteritis in cases of FIR 2. In FIR 1, the highest performing model assigned high attention to areas of activated-appearing stroma in Wharton's Jelly. However, other high-performing models assigned attention to umbilical vessels. We developed models for diagnosis of FIR from placental histology images, helping reduce interobserver variability among pathologists. Future work may examine the utility of these models for identifying infants at risk of systemic inflammatory response or early onset neonatal sepsis.

We consider the problem of estimating the transition dynamics $T^*$ from near-optimal expert trajectories in the context of offline model-based reinforcement learning. We develop a novel constraint-based method, Inverse Transition Learning, that treats the limited coverage of the expert trajectories as a \emph{feature}: we use the fact that the expert is near-optimal to inform our estimate of $T^*$. We integrate our constraints into a Bayesian approach. Across both synthetic environments and real healthcare scenarios like Intensive Care Unit (ICU) patient management in hypotension, we demonstrate not only significant improvements in decision-making, but that our posterior can inform when transfer will be successful.

Within batch reinforcement learning, safe policy improvement (SPI) seeks to ensure that the learnt policy performs at least as well as the behavior policy that generated the dataset. The core challenge in SPI is seeking improvements while balancing risk when many state-action pairs may be infrequently visited. In this work, we introduce Decision Points RL (DPRL), an algorithm that restricts the set of state-action pairs (or regions for continuous states) considered for improvement. DPRL ensures high-confidence improvement in densely visited states (i.e. decision points) while still utilizing data from sparsely visited states. By appropriately limiting where and how we may deviate from the behavior policy, we achieve tighter bounds than prior work; specifically, our data-dependent bounds do not scale with the size of the state and action spaces. In addition to the analysis, we demonstrate that DPRL is both safe and performant on synthetic and real datasets.

Lablets are autonomous microscopic particles with programmable CMOS electronics that can control electrokinetic phenomena and electrochemical reactions in solution via actuator and sensor microelectrodes. In this paper, we describe the design and fabrication of optimized singulated lablets (CMOS3) with dimensions 140x140x50 micrometers carrying an integrated coplanar encapsulated supercapacitor as a rechargeable power supply. The lablets are designed to allow docking to one another or to a smart surface for interchange of energy, electronic information, and chemicals. The paper focusses on the digital and analog design of the lablets to allow significant programmable functionality in a microscopic footprint, including the control of autonomous actuation and sensing up to the level of being able to support a complete lablet self-reproduction life cycle, although experimentally this remains to be proven. The potential of lablets in autonomous sensing and control and for evolutionary experimentation are discussed.

The programmable investigation and control of chemical systems at the microscale has been an increasingly successful area in microsystem technology for over 25 years including our own work in lab-on-a-chip and microfluidics to approach electronic chemical cells [1-2]. These systems require and are limited by their physical connection (wires, tubes, pipetting) to the macroscopic control system, both for electrical and chemical interfacing. Wireless electronic systems, communicating using radio waves, although already advocated for smart dust [3-4] and implemented down to mm scales, are not yet effective at 100 µm scales and below, especially in aqueous solution where communication is damped, and also do not provide a solution for powering smart microscopic electronic particles in solution. Our approach is a novel and more chemically inspired one [5] - to take advantage of the mobility of microscopic particles which allows their docking to one another pairwise or to a smart microstructured surface (called the dock). It involves fully programmable CMOS electronic particles in contrast to other more restricted approaches such as plasmonic smart dust [6]. Electronic integration using CMOS has been optimized for high speed (GHz range) operation and high integration levels with feature sizes down to 30nm and below. However, for microscopic electronics, extremely low power operation is required (total average power, typically 1 nW for 1000s) by current microscopic charge storage limitations ( 2 µF using supercap technology), which is not consistent either with high frequency operation or the leakage currents associated with the finest scale transistors. Instead, low power operation has been achieved using 180nm technology and an especially designed slow clock [7] and custom transistor design. Electronic actuation of chemical reactions mostly requires switching of voltages on microelectrodes in aqueous solution, which typically have significant capacitances, as exploited in electrolyte capacitors.

The detection of human parts (e.g., hands, face) and their correct association with individuals is an essential task, e.g., for ubiquitous human-machine interfaces and action recognition. Traditional methods often employ multi-stage processes, rely on cumbersome anchor-based systems, or do not scale well to larger part sets. This paper presents PBADet, a novel one-stage, anchor-free approach for part-body association detection. Building upon the anchor-free object representation across multi-scale feature maps, we introduce a singular part-to-body center offset that effectively encapsulates the relationship between parts and their parent bodies. Our design is inherently versatile and capable of managing multiple parts-to-body associations without compromising on detection accuracy or robustness. Comprehensive experiments on various datasets underscore the efficacy of our approach, which not only outperforms existing state-of-the-art techniques but also offers a more streamlined and efficient solution to the part-body association challenge.