Deep learning-based computer-aided diagnosis (CAD) of medical images requires large datasets. However, the lack of large publicly available labeled datasets limits the development of deep learning-based CAD systems. Generative Adversarial Networks (GANs), in particular, CycleGAN, can be used to generate new cross-domain images without paired training data. However, most CycleGAN-based synthesis methods lack the potential to overcome alignment and asymmetry between the input and generated data. We propose a two-stage technique for the synthesis of abdominal MRI using cross-modality translation of abdominal CT. We show that the synthetic data can help improve the performance of the liver segmentation network. We increase the number of abdominal MRI images through cross-modality image transformation of unpaired CT images using a CycleGAN inspired deformation invariant network called EssNet. Subsequently, we combine the synthetic MRI images with the original MRI images and use them to improve the accuracy of the U-Net on a liver segmentation task. We train the U-Net on real MRI images and then on real and synthetic MRI images. Consequently, by comparing both scenarios, we achieve an improvement in the performance of U-Net. In summary, the improvement achieved in the Intersection over Union (IoU) is 1.17%. The results show potential to address the data scarcity challenge in medical imaging.

Applying deep learning (DL) for annotating surgical instruments in robot-assisted minimally invasive surgeries (MIS) represents a significant advancement in surgical technology. This systematic review examines 48 studies that and advanced DL methods and architectures. These sophisticated DL models have shown notable improvements in the precision and efficiency of detecting and segmenting surgical tools. The enhanced capabilities of these models support various clinical applications, including real-time intraoperative guidance, comprehensive postoperative evaluations, and objective assessments of surgical skills. By accurately identifying and segmenting surgical instruments in video data, DL models provide detailed feedback to surgeons, thereby improving surgical outcomes and reducing complication risks. Furthermore, the application of DL in surgical education is transformative. The review underscores the significant impact of DL on improving the accuracy of skill assessments and the overall quality of surgical training programs. However, implementing DL in surgical tool detection and segmentation faces challenges, such as the need for large, accurately annotated datasets to train these models effectively. The manual annotation process is labor-intensive and time-consuming, posing a significant bottleneck. Future research should focus on automating the detection and segmentation process and enhancing the robustness of DL models against environmental variations. Expanding the application of DL models across various surgical specialties will be essential to fully realize this technology's potential. Integrating DL with other emerging technologies, such as augmented reality (AR), also offers promising opportunities to further enhance the precision and efficacy of surgical procedures.

Recent developments in multimodal large language models (MLLMs) have spurred significant interest in their potential applications across various medical imaging domains. On the one hand, there is a temptation to use these generative models to synthesize realistic-looking medical image data, while on the other hand, the ability to identify synthetic image data in a pool of data is also significantly important. In this study, we explore the potential of the Gemini (\textit{gemini-1.0-pro-vision-latest}) and GPT-4V (gpt-4-vision-preview) models for medical image analysis using two modalities of medical image data. Utilizing synthetic and real imaging data, both Gemini AI and GPT-4V are first used to classify real versus synthetic images, followed by an interpretation and analysis of the input images. Experimental results demonstrate that both Gemini and GPT-4 could perform some interpretation of the input images. In this specific experiment, Gemini was able to perform slightly better than the GPT-4V on the classification task. In contrast, responses associated with GPT-4V were mostly generic in nature. Our early investigation presented in this work provides insights into the potential of MLLMs to assist with the classification and interpretation of retinal fundoscopy and lung X-ray images. We also identify key limitations associated with the early investigation study on MLLMs for specialized tasks in medical image analysis.

The advanced large language model (LLM) ChatGPT has shown its potential in different domains and remains unbeaten due to its characteristics compared to other LLMs. This study aims to evaluate the potential of using a fine-tuned ChatGPT model as a personal medical assistant in the Arabic language. To do so, this study uses publicly available online questions and answering datasets in Arabic language. There are almost 430K questions and answers for 20 disease-specific categories. GPT-3.5-turbo model was fine-tuned with a portion of this dataset. The performance of this fine-tuned model was evaluated through automated and human evaluation. The automated evaluations include perplexity, coherence, similarity, and token count. Native Arabic speakers with medical knowledge evaluated the generated text by calculating relevance, accuracy, precision, logic, and originality. The overall result shows that ChatGPT has a bright future in medical assistance.

Vision transformer-based methods are advancing the field of medical artificial intelligence and cancer imaging, including lung cancer applications. Recently, many researchers have developed vision transformer-based AI methods for lung cancer diagnosis and prognosis. This scoping review aims to identify the recent developments on vision transformer-based AI methods for lung cancer imaging applications. It provides key insights into how vision transformers complemented the performance of AI and deep learning methods for lung cancer. Furthermore, the review also identifies the datasets that contributed to advancing the field. Of the 314 retrieved studies, this review included 34 studies published from 2020 to 2022. The most commonly addressed task in these studies was the classification of lung cancer types, such as lung squamous cell carcinoma versus lung adenocarcinoma, and identifying benign versus malignant pulmonary nodules. Other applications included survival prediction of lung cancer patients and segmentation of lungs. The studies lacked clear strategies for clinical transformation. SWIN transformer was a popular choice of the researchers; however, many other architectures were also reported where vision transformer was combined with convolutional neural networks or UNet model. It can be concluded that vision transformer-based models are increasingly in popularity for developing AI methods for lung cancer applications. However, their computational complexity and clinical relevance are important factors to be considered for future research work. This review provides valuable insights for researchers in the field of AI and healthcare to advance the state-of-the-art in lung cancer diagnosis and prognosis. We provide an interactive dashboard on lung-cancer.onrender.com/.

The rising prevalence of type 2 diabetes mellitus (T2DM) necessitates the development of predictive models for T2DM risk assessment. Artificial intelligence (AI) models are being extensively used for this purpose, but a comprehensive review of their advancements and challenges is lacking. This scoping review analyzes existing literature on AI-based models for T2DM risk prediction. Forty studies were included, mainly published in the past four years. Traditional machine learning models were more prevalent than deep learning models. Electronic health records were the most commonly used data source. Unimodal AI models relying on EHR data were prominent, while only a few utilized multimodal models. Both unimodal and multimodal models showed promising performance, with the latter outperforming the former. Internal validation was common, while external validation was limited. Interpretability methods were reported in half of the studies. Few studies reported novel biomarkers, and open-source code availability was limited. This review provides insights into the current state and limitations of AI-based T2DM risk prediction models and highlights challenges for their development and clinical implementation.

Artificial Intelligence (AI)-based models can help in diagnosing COVID-19 from lung CT scans and X-ray images; however, these models require large amounts of data for training and validation. Many researchers studied Generative Adversarial Networks (GANs) for producing synthetic lung CT scans and X-Ray images to improve the performance of AI-based models. It is not well explored how good GAN-based methods performed to generate reliable synthetic data. This work analyzes 43 published studies that reported GANs for synthetic data generation. Many of these studies suffered data bias, lack of reproducibility, and lack of feedback from the radiologists or other domain experts. A common issue in these studies is the unavailability of the source code, hindering reproducibility. The included studies reported rescaling of the input images to train the existing GANs architecture without providing clinical insights on how the rescaling was motivated. Finally, even though GAN-based methods have the potential for data augmentation and improving the training of AI-based models, these methods fall short in terms of their use in clinical practice. This paper highlights research hotspots in countering the data scarcity problem, identifies various issues as well as potentials, and provides recommendations to guide future research. These recommendations might be useful to improve acceptability for the GAN-based approaches for data augmentation as GANs for data augmentation are increasingly becoming popular in the AI and medical imaging research community.

Generative models have been very successful over the years and have received significant attention for synthetic data generation. As deep learning models are getting more and more complex, they require large amounts of data to perform accurately. In medical image analysis, such generative models play a crucial role as the available data is limited due to challenges related to data privacy, lack of data diversity, or uneven data distributions. In this paper, we present a method to generate brain tumor MRI images using generative adversarial networks. We have utilized StyleGAN2 with ADA methodology to generate high-quality brain MRI with tumors while using a significantly smaller amount of training data when compared to the existing approaches. We use three pre-trained models for transfer learning. Results demonstrate that the proposed method can learn the distributions of brain tumors. Furthermore, the model can generate high-quality synthetic brain MRI with a tumor that can limit the small sample size issues. The approach can addresses the limited data availability by generating realistic-looking brain MRI with tumors.