The Complementarity Determining Region (CDR) structure prediction of loops in antibody engineering has gained a lot of attraction by researchers. When designing antibodies, a main challenge is to predict the CDR structure of the H3 loop. Compared with the other CDR loops, that is the H1 and H2 loops, the CDR structure of the H3 loop is more challenging due to its varying length and flexible structure. In this paper, we propose a Multi-task learning model with Loop Specific Attention, namely MLSA. In particular, to the best of our knowledge we are the first to jointly learn the three CDR loops, via a novel multi-task learning strategy. In addition, to account for the structural and functional similarities and differences of the three CDR loops, we propose a loop specific attention mechanism to control the influence of each CDR loop on the training of MLSA. Our experimental evaluation on widely used benchmark data shows that the proposed MLSA method significantly reduces the prediction error of the CDR structure of the H3 loop, by at least 19%, when compared with other baseline strategies. Finally, for reproduction purposes we make the implementation of MLSA publicly available at https://anonymous.4open.science/r/MLSA-2442/.

Accounting for the fact that users have different sequential patterns, the main drawback of state-of-the-art recommendation strategies is that a fixed sequence length of user-item interactions is required as input to train the models. This might limit the recommendation accuracy, as in practice users follow different trends on the sequential recommendations. Hence, baseline strategies might ignore important sequential interactions or add noise to the models with redundant interactions, depending on the variety of users' sequential behaviours. To overcome this problem, in this study we propose the SAR model, which not only learns the sequential patterns but also adjusts the sequence length of user-item interactions in a personalized manner. We first design an actor-critic framework, where the RL agent tries to compute the optimal sequence length as an action, given the user's state representation at a certain time step. In addition, we optimize a joint loss function to align the accuracy of the sequential recommendations with the expected cumulative rewards of the critic network, while at the same time we adapt the sequence length with the actor network in a personalized manner. Our experimental evaluation on four real-world datasets demonstrates the superiority of our proposed model over several baseline approaches. Finally, we make our implementation publicly available at https://github.com/stefanosantaris/sar.

In this paper we present a deep graph reinforcement learning model to predict and improve the user experience during a live video streaming event, orchestrated by an agent/tracker. We first formulate the user experience prediction problem as a classification task, accounting for the fact that most of the viewers at the beginning of an event have poor quality of experience due to low-bandwidth connections and limited interactions with the tracker. In our model we consider different factors that influence the quality of user experience and train the proposed model on diverse state-action transitions when viewers interact with the tracker. In addition, provided that past events have various user experience characteristics we follow a gradient boosting strategy to compute a global model that learns from different events. Our experiments with three real-world datasets of live video streaming events demonstrate the superiority of the proposed model against several baseline strategies. Moreover, as the majority of the viewers at the beginning of an event has poor experience, we show that our model can significantly increase the number of viewers with high quality experience by at least 75% over the first streaming minutes. Our evaluation datasets and implementation are publicly available at https://publicresearch.z13.web.core.windows.net

Nowadays, live video streaming events have become a mainstay in viewer's communication in large international enterprises. Provided that viewers are distributed worldwide, the main challenge resides on how to schedule the optimal event's time so as to improve both the viewer's engagement and adoption. In this paper we present a multi-task deep reinforcement learning model to select the time of a live video streaming event, aiming to optimize the viewer's engagement and adoption at the same time. We consider the engagement and adoption of the viewers as independent tasks and formulate a unified loss function to learn a common policy. In addition, we account for the fact that each task might have different contribution to the training strategy of the agent. Therefore, to determine the contribution of each task to the agent's training, we design a Transformer's architecture for the state-action transitions of each task. We evaluate our proposed model on four real-world datasets, generated by the live video streaming events of four large enterprises spanning from January 2019 until March 2021. Our experiments demonstrate the effectiveness of the proposed model when compared with several state-of-the-art strategies. For reproduction purposes, our evaluation datasets and implementation are publicly available at https://github.com/stefanosantaris/merlin.

Live video streaming has become a mainstay as a standard communication solution for several enterprises worldwide. To efficiently stream high-quality live video content to a large amount of offices, companies employ distributed video streaming solutions which rely on prior knowledge of the underlying evolving enterprise network. However, such networks are highly complex and dynamic. Hence, to optimally coordinate the live video distribution, the available network capacity between viewers has to be accurately predicted. In this paper we propose a graph representation learning technique on weighted and dynamic graphs to predict the network capacity, that is the weights of connections/links between viewers/nodes. We propose VStreamDRLS, a graph neural network architecture with a self-attention mechanism to capture the evolution of the graph structure of live video streaming events. VStreamDRLS employs the graph convolutional network (GCN) model over the duration of a live video streaming event and introduces a self-attention mechanism to evolve the GCN parameters. In doing so, our model focuses on the GCN weights that are relevant to the evolution of the graph and generate the node representation, accordingly. We evaluate our proposed approach on the link prediction task on two real-world datasets, generated by enterprise live video streaming events. The duration of each event lasted an hour. The experimental results demonstrate the effectiveness of VStreamDRLS when compared with state-of-the-art strategies. Our evaluation datasets and implementation are publicly available at https://github.com/stefanosantaris/vstreamdrls

In this study, we present a dynamic graph representation learning model on weighted graphs to accurately predict the network capacity of connections between viewers in a live video streaming event. We propose EGAD, a neural network architecture to capture the graph evolution by introducing a self-attention mechanism on the weights between consecutive graph convolutional networks. In addition, we account for the fact that neural architectures require a huge amount of parameters to train, thus increasing the online inference latency and negatively influencing the user experience in a live video streaming event. To address the problem of the high online inference of a vast number of parameters, we propose a knowledge distillation strategy. In particular, we design a distillation loss function, aiming to first pretrain a teacher model on offline data, and then transfer the knowledge from the teacher to a smaller student model with less parameters. We evaluate our proposed model on the link prediction task on three real-world datasets, generated by live video streaming events. The events lasted 80 minutes and each viewer exploited the distribution solution provided by the company Hive Streaming AB. The experiments demonstrate the effectiveness of the proposed model in terms of link prediction accuracy and number of required parameters, when evaluated against state-of-the-art approaches. In addition, we study the distillation performance of the proposed model in terms of compression ratio for different distillation strategies, where we show that the proposed model can achieve a compression ratio up to 15:100, preserving high link prediction accuracy. For reproduction purposes, our evaluation datasets and implementation are publicly available at https://stefanosantaris.github.io/EGAD.

Dynamic graph representation learning strategies are based on different neural architectures to capture the graph evolution over time. However, the underlying neural architectures require a large amount of parameters to train and suffer from high online inference latency, that is several model parameters have to be updated when new data arrive online. In this study we propose Distill2Vec, a knowledge distillation strategy to train a compact model with a low number of trainable parameters, so as to reduce the latency of online inference and maintain the model accuracy high. We design a distillation loss function based on Kullback-Leibler divergence to transfer the acquired knowledge from a teacher model trained on offline data, to a small-size student model for online data. Our experiments with publicly available datasets show the superiority of our proposed model over several state-of-the-art approaches with relative gains up to 5% in the link prediction task. In addition, we demonstrate the effectiveness of our knowledge distillation strategy, in terms of number of required parameters, where Distill2Vec achieves a compression ratio up to 7:100 when compared with baseline approaches. For reproduction purposes, our implementation is publicly available at https://stefanosantaris.github.io/Distill2Vec.

Deep learning has proved an effective means to capture the non-linear associations of user preferences. However, the main drawback of existing deep learning architectures is that they follow a fixed recommendation strategy, ignoring users' real time-feedback. Recent advances of deep reinforcement strategies showed that recommendation policies can be continuously updated while users interact with the system. In doing so, we can learn the optimal policy that fits to users' preferences over the recommendation sessions. The main drawback of deep reinforcement strategies is that are based on predefined and fixed neural architectures. To shed light on how to handle this issue, in this study we first present deep reinforcement learning strategies for recommendation and discuss the main limitations due to the fixed neural architectures. Then, we detail how recent advances on progressive neural architectures are used for consecutive tasks in other research domains. Finally, we present the key challenges to fill the gap between deep reinforcement learning and adaptive neural architectures. We provide guidelines for searching for the best neural architecture based on each user feedback via reinforcement learning, while considering the prediction performance on real-time recommendations and the model complexity.

Conversational recommendation systems have recently gain a lot of attention, as users can continuously interact with the system over multiple conversational turns. However, conversational recommendation systems are based on complex neural architectures, thus the training cost of such models is high. To shed light on the high computational training time of state-of-the art conversational models, we examine five representative strategies and demonstrate this issue. Furthermore, we discuss possible ways to cope with the high training cost following knowledge distillation strategies, where we detail the key challenges to reduce the online inference time of the high number of model parameters in conversational recommendation systems

With the proliferation of social media platforms and e-commerce sites, several cross-domain collaborative filtering strategies have been recently introduced to transfer the knowledge of user preferences across domains. The main challenge of cross-domain recommendation is to weigh and learn users' different behaviors in multiple domains. In this paper, we propose a Cross-Domain collaborative filtering model following a Translation-based strategy, namely CDT. In our model, we learn the embedding space with translation vectors and capture high-order feature interactions in users' multiple preferences across domains. In doing so, we efficiently compute the transitivity between feature latent embeddings, that is if feature pairs have high interaction weights in the latent space, then feature embeddings with no observed interactions across the domains will be closely related as well. We formulate our objective function as a ranking problem in factorization machines and learn the model's parameters via gradient descent. In addition, to better capture the non-linearity in user preferences across domains we extend the proposed CDT model by using a deep learning strategy, namely DeepCDT. Our experiments on six publicly available cross-domain tasks demonstrate the effectiveness of the proposed models, outperforming other state-of-the-art cross-domain strategies.