Purpose: To introduce a deep learning model capable of multi-organ segmentation in MRI scans, offering a solution to the current limitations in MRI analysis due to challenges in resolution, standardized intensity values, and variability in sequences. Materials and Methods: he model was trained on 1,200 manually annotated MRI scans from the UK Biobank, 221 in-house MRI scans and 1228 CT scans, leveraging cross-modality transfer learning from CT segmentation models. A human-in-the-loop annotation workflow was employed to efficiently create high-quality segmentations. The model's performance was evaluated on NAKO and the AMOS22 dataset containing 600 and 60 MRI examinations. Dice Similarity Coefficient (DSC) and Hausdorff Distance (HD) was used to assess segmentation accuracy. The model will be open sourced. Results: The model showcased high accuracy in segmenting well-defined organs, achieving Dice Similarity Coefficient (DSC) scores of 0.97 for the right and left lungs, and 0.95 for the heart. It also demonstrated robustness in organs like the liver (DSC: 0.96) and kidneys (DSC: 0.95 left, 0.95 right), which present more variability. However, segmentation of smaller and complex structures such as the portal and splenic veins (DSC: 0.54) and adrenal glands (DSC: 0.65 left, 0.61 right) revealed the need for further model optimization. Conclusion: The proposed model is a robust, tool for accurate segmentation of 40 anatomical structures in MRI and CT images. By leveraging cross-modality learning and interactive annotation, the model achieves strong performance and generalizability across diverse datasets, making it a valuable resource for researchers and clinicians. It is open source and can be downloaded from https://github.com/hhaentze/MRSegmentator.

Transfer learning leverages pre-trained model features from a large dataset to save time and resources when training new models for various tasks, potentially enhancing performance. Due to the lack of large datasets in the medical imaging domain, transfer learning from one medical imaging model to other medical imaging models has not been widely explored. This study explores the use of transfer learning to improve the performance of deep convolutional neural networks for organ segmentation in medical imaging. A base segmentation model (3D U-Net) was trained on a large and sparsely annotated dataset; its weights were used for transfer learning on four new down-stream segmentation tasks for which a fully annotated dataset was available. We analyzed the training set size's influence to simulate scarce data. The results showed that transfer learning from the base model was beneficial when small datasets were available, providing significant performance improvements; where fine-tuning the base model is more beneficial than updating all the network weights with vanilla transfer learning. Transfer learning with fine-tuning increased the performance by up to 0.129 (+28\%) Dice score than experiments trained from scratch, and on average 23 experiments increased the performance by 0.029 Dice score in the new segmentation tasks. The study also showed that cross-modality transfer learning using CT scans was beneficial. The findings of this study demonstrate the potential of transfer learning to improve the efficiency of annotation and increase the accessibility of accurate organ segmentation in medical imaging, ultimately leading to improved patient care. We made the network definition and weights publicly available to benefit other users and researchers.