Chatbots or conversational agents (CAs) are increasingly used to improve access to digital psychotherapy. Many current systems rely on rigid, rule-based designs, heavily dependent on expert-crafted dialogue scripts for guiding therapeutic conversations. Although recent advances in large language models (LLMs) offer the potential for more flexible interactions, their lack of controllability and transparency poses significant challenges in sensitive areas like psychotherapy. In this work, we explored how aligning LLMs with expert-crafted scripts can enhance psychotherapeutic chatbot performance. Our comparative study showed that LLMs aligned with expert-crafted scripts through prompting and fine-tuning significantly outperformed both pure LLMs and rule-based chatbots, achieving a more effective balance between dialogue flexibility and adherence to therapeutic principles. Building on findings, we proposed ``Script-Strategy Aligned Generation (SSAG)'', a flexible alignment approach that reduces reliance on fully scripted content while enhancing LLMs' therapeutic adherence and controllability. In a 10-day field study, SSAG demonstrated performance comparable to full script alignment and outperformed rule-based chatbots, empirically supporting SSAG as an efficient approach for aligning LLMs with domain expertise. Our work advances LLM applications in psychotherapy by providing a controllable, adaptable, and scalable solution for digital interventions, reducing reliance on expert effort. It also provides a collaborative framework for domain experts and developers to efficiently build expertise-aligned chatbots, broadening access to psychotherapy and behavioral interventions.

Retrieval-augmented generation has gained popularity as a framework to enhance large language models with external knowledge. However, its effectiveness hinges on the retrieval robustness of the model. If the model lacks retrieval robustness, its performance is constrained by the accuracy of the retriever, resulting in significant compromises when the retrieved context is irrelevant. In this paper, we evaluate the "implicit" retrieval robustness of various large language models, instructing them to directly output the final answer without explicitly judging the relevance of the retrieved context. Our findings reveal that fine-tuning on a mix of gold and distracting context significantly enhances the model's robustness to retrieval inaccuracies, while still maintaining its ability to extract correct answers when retrieval is accurate. This suggests that large language models can implicitly handle relevant or irrelevant retrieved context by learning solely from the supervision of the final answer in an end-to-end manner. Introducing an additional process for explicit relevance judgment can be unnecessary and disrupts the end-to-end approach.

Parameter-efficient fine-tuning (PEFT) is a popular method for tailoring pre-trained large language models (LLMs), especially as the models' scale and the diversity of tasks increase. Low-rank adaptation (LoRA) is based on the idea that the adaptation process is intrinsically low-dimensional, i.e., significant model changes can be represented with relatively few parameters. However, decreasing the rank encounters challenges with generalization errors for specific tasks when compared to full-parameter fine-tuning. We present MELoRA, a mini-ensemble low-rank adapters that uses fewer trainable parameters while maintaining a higher rank, thereby offering improved performance potential. The core idea is to freeze original pretrained weights and train a group of mini LoRAs with only a small number of parameters. This can capture a significant degree of diversity among mini LoRAs, thus promoting better generalization ability. We conduct a theoretical analysis and empirical studies on various NLP tasks. Our experimental results show that, compared to LoRA, MELoRA achieves better performance with 8 times fewer trainable parameters on natural language understanding tasks and 36 times fewer trainable parameters on instruction following tasks, which demonstrates the effectiveness of MELoRA.

Large language models (LLMs) often produce unsupported or unverifiable information, known as "hallucinations." To mitigate this, retrieval-augmented LLMs incorporate citations, grounding the content in verifiable sources. Despite such developments, manually assessing how well a citation supports the associated statement remains a major challenge. Previous studies use faithfulness metrics to estimate citation support automatically but are limited to binary classification, overlooking fine-grained citation support in practical scenarios. To investigate the effectiveness of faithfulness metrics in fine-grained scenarios, we propose a comparative evaluation framework that assesses the metric effectiveness in distinguishinging citations between three-category support levels: full, partial, and no support. Our framework employs correlation analysis, classification evaluation, and retrieval evaluation to measure the alignment between metric scores and human judgments comprehensively. Our results show no single metric consistently excels across all evaluations, revealing the complexity of assessing fine-grained support. Based on the findings, we provide practical recommendations for developing more effective metrics.

Autonomous artificial intelligence (AI) agents have emerged as promising protocols for automatically understanding the language-based environment, particularly with the exponential development of large language models (LLMs). However, a fine-grained, comprehensive understanding of multimodal environments remains under-explored. This work designs an autonomous workflow tailored for integrating AI agents seamlessly into extended reality (XR) applications for fine-grained training. We present a demonstration of a multimodal fine-grained training assistant for LEGO brick assembly in a pilot XR environment. Specifically, we design a cerebral language agent that integrates LLM with memory, planning, and interaction with XR tools and a vision-language agent, enabling agents to decide their actions based on past experiences. Furthermore, we introduce LEGO-MRTA, a multimodal fine-grained assembly dialogue dataset synthesized automatically in the workflow served by a commercial LLM. This dataset comprises multimodal instruction manuals, conversations, XR responses, and vision question answering. Last, we present several prevailing open-resource LLMs as benchmarks, assessing their performance with and without fine-tuning on the proposed dataset. We anticipate that the broader impact of this workflow will advance the development of smarter assistants for seamless user interaction in XR environments, fostering research in both AI and HCI communities.

Pre-trained language models (PLMs) have been the de facto paradigm for most natural language processing (NLP) tasks. This also benefits biomedical domain: researchers from informatics, medicine, and computer science (CS) communities propose various PLMs trained on biomedical datasets, e.g., biomedical text, electronic health records, protein, and DNA sequences for various biomedical tasks. However, the cross-discipline characteristics of biomedical PLMs hinder their spreading among communities; some existing works are isolated from each other without comprehensive comparison and discussions. It expects a survey that not only systematically reviews recent advances of biomedical PLMs and their applications but also standardizes terminology and benchmarks. In this paper, we summarize the recent progress of pre-trained language models in the biomedical domain and their applications in biomedical downstream tasks. Particularly, we discuss the motivations and propose a taxonomy of existing biomedical PLMs. Their applications in biomedical downstream tasks are exhaustively discussed. At last, we illustrate various limitations and future trends, which we hope can provide inspiration for the future research of the research community.

Answer selection in open-domain dialogues aims to select an accurate answer from candidates. Recent success of answer selection models hinges on training with large amounts of labeled data. However, collecting large-scale labeled data is labor-intensive and time-consuming. In this paper, we introduce the predicted intent labels to calibrate answer labels in a self-training paradigm. Specifically, we propose the intent-calibrated self-training (ICAST) to improve the quality of pseudo answer labels through the intent-calibrated answer selection paradigm, in which we employ pseudo intent labels to help improve pseudo answer labels. We carry out extensive experiments on two benchmark datasets with open-domain dialogues. The experimental results show that ICAST outperforms baselines consistently with 1%, 5% and 10% labeled data. Specifically, it improves 2.06% and 1.00% of F1 score on the two datasets, compared with the strongest baseline with only 5% labeled data.

Transformers are state-of-the-art in a wide range of NLP tasks and have also been applied to many real-world products. Understanding the reliability and certainty of transformer model predictions is crucial for building trustable machine learning applications, e.g., medical diagnosis. Although many recent transformer extensions have been proposed, the study of the uncertainty estimation of transformer models is under-explored. In this work, we propose a novel way to enable transformers to have the capability of uncertainty estimation and, meanwhile, retain the original predictive performance. This is achieved by learning a hierarchical stochastic self-attention that attends to values and a set of learnable centroids, respectively. Then new attention heads are formed with a mixture of sampled centroids using the Gumbel-Softmax trick. We theoretically show that the self-attention approximation by sampling from a Gumbel distribution is upper bounded. We empirically evaluate our model on two text classification tasks with both in-domain (ID) and out-of-domain (OOD) datasets. The experimental results demonstrate that our approach: (1) achieves the best predictive performance and uncertainty trade-off among compared methods; (2) exhibits very competitive (in most cases, improved) predictive performance on ID datasets; (3) is on par with Monte Carlo dropout and ensemble methods in uncertainty estimation on OOD datasets.

Medical dialogue systems (MDSs) aim to assist doctors and patients with a range of professional medical services, i.e., diagnosis, consultation, and treatment. However, one-stop MDS is still unexplored because: (1) no dataset has so large-scale dialogues contains both multiple medical services and fine-grained medical labels (i.e., intents, slots, values); (2) no model has addressed a MDS based on multiple-service conversations in a unified framework. In this work, we first build a Multiple-domain Multiple-service medical dialogue (M^2-MedDialog)dataset, which contains 1,557 conversations between doctors and patients, covering 276 types of diseases, 2,468 medical entities, and 3 specialties of medical services. To the best of our knowledge, it is the only medical dialogue dataset that includes both multiple medical services and fine-grained medical labels. Then, we formulate a one-stop MDS as a sequence-to-sequence generation problem. We unify a MDS with causal language modeling and conditional causal language modeling, respectively. Specifically, we employ several pretrained models (i.e., BERT-WWM, BERT-MED, GPT2, and MT5) and their variants to get benchmarks on M^2-MedDialog dataset. We also propose pseudo labeling and natural perturbation methods to expand M2-MedDialog dataset and enhance the state-of-the-art pretrained models. We demonstrate the results achieved by the benchmarks so far through extensive experiments on M2-MedDialog. We release the dataset, the code, as well as the evaluation scripts to facilitate future research in this important research direction.

There is increasing interest in developing personalized Task-oriented Dialogue Systems (TDSs). Previous work on personalized TDSs often assumes that complete user profiles are available for most or even all users. This is unrealistic because (1) not everyone is willing to expose their profiles due to privacy concerns; and (2) rich user profiles may involve a large number of attributes (e.g., gender, age, tastes, . . .). In this paper, we study personalized TDSs without assuming that user profiles are complete. We propose a Cooperative Memory Network (CoMemNN) that has a novel mechanism to gradually enrich user profiles as dialogues progress and to simultaneously improve response selection based on the enriched profiles. CoMemNN consists of two core modules: User Profile Enrichment (UPE) and Dialogue Response Selection (DRS). The former enriches incomplete user profiles by utilizing collaborative information from neighbor users as well as current dialogues. The latter uses the enriched profiles to update the current user query so as to encode more useful information, based on which a personalized response to a user request is selected. We conduct extensive experiments on the personalized bAbI dialogue benchmark datasets. We find that CoMemNN is able to enrich user profiles effectively, which results in an improvement of 3.06% in terms of response selection accuracy compared to state-of-the-art methods. We also test the robustness of CoMemNN against incompleteness of user profiles by randomly discarding attribute values from user profiles. Even when discarding 50% of the attribute values, CoMemNN is able to match the performance of the best performing baseline without discarding user profiles, showing the robustness of CoMemNN.