While deep learning models play a crucial role in predicting antibody-antigen interactions (AAI), the scarcity of publicly available sequence-structure pairings constrains their generalization. Current AAI methods often focus on residue-level static details, overlooking fine-grained structural representations of antibodies and their inter-antibody similarities. To tackle this challenge, we introduce a multi-modality representation approach that integates 3D structural and 1D sequence data to unravel intricate intra-antibody hierarchical relationships. By harnessing these representations, we present MuLAAIP, an AAI prediction framework that utilizes graph attention networks to illuminate graph-level structural features and normalized adaptive graph convolution networks to capture inter-antibody sequence associations. Furthermore, we have curated an AAI benchmark dataset comprising both structural and sequence information along with interaction labels. Through extensive experiments on this benchmark, our results demonstrate that MuLAAIP outperforms current state-of-the-art methods in terms of predictive performance. The implementation code and dataset are publicly available at https://github.com/trashTian/MuLAAIP for reproducibility.

Robotic manipulation refers to the autonomous handling and interaction of robots with objects using advanced techniques in robotics and artificial intelligence. The advent of powerful tools such as large language models (LLMs) and large vision-language models (LVLMs) has significantly enhanced the capabilities of these robots in environmental perception and decision-making. However, the introduction of these intelligent agents has led to security threats such as jailbreak attacks and adversarial attacks. In this research, we take a further step by proposing a backdoor attack specifically targeting robotic manipulation and, for the first time, implementing backdoor attack in the physical world. By embedding a backdoor visual language model into the visual perception module within the robotic system, we successfully mislead the robotic arm's operation in the physical world, given the presence of common items as triggers. Experimental evaluations in the physical world demonstrate the effectiveness of the proposed backdoor attack.