Drug repositioning is an economically efficient strategy used to discover new indications for existing drugs beyond their original approvals, expanding their applicability and usage to address challenges in disease treatment. In recent years, deep-learning techniques for drug repositioning have gained much attention. While most deep learning-based research methods focus on encoding drugs and diseases by extracting feature information from neighbors in the network, they often pay little attention to the potential relationships between the features of drugs and diseases, leading to imprecise encoding of drugs and diseases. To address this, we design a dual-feature drug repositioning neural network (DFDRNN) model to achieve precise encoding of drugs and diseases. DFDRNN uses two features to represent drugs and diseases: the similarity feature and the association feature. The model incorporates a self-attention mechanism to design two dual-feature extraction modules for achieving precisely encoding of drugs and diseases: the intra-domain dual-feature extraction (IntraDDFE) module and the inter-domain dual-feature extraction (InterDDFE) module. The IntraDDFE module extracts features from a single domain (drug or disease domain), while the InterDDFE module extracts features from the mixed domain (drug and disease domain). In particular, the feature is changed by InterDDFE, ensuring a precise encoding of drugs and diseases. Finally, a cross-dual-domain decoder is designed to predict drug-disease associations in both the drug and disease domains. Compared to six state-of-the-art methods, DFDRNN outperforms others on four benchmark datasets, with an average AUROC of 0.946 and an average AUPR of 0.597.

In this paper, we present a novel embedded feature selection method based on a Multi-layer Perceptron (MLP) network and generalize it for group-feature or sensor selection problems, which can control the level of redundancy among the selected features or groups. Additionally, we have generalized the group lasso penalty for feature selection to encompass a mechanism for selecting valuable group features while simultaneously maintaining a control over redundancy. We establish the monotonicity and convergence of the proposed algorithm, with a smoothed version of the penalty terms, under suitable assumptions. Experimental results on several benchmark datasets demonstrate the promising performance of the proposed methodology for both feature selection and group feature selection over some state-of-the-art methods.

When a data set has significant differences in its class and cluster structure, selecting features aiming only at the discrimination of classes would lead to poor clustering performance, and similarly, feature selection aiming only at preserving cluster structures would lead to poor classification performance. To the best of our knowledge, a feature selection method that simultaneously considers class discrimination and cluster structure preservation is not available in the literature. In this paper, we have tried to bridge this gap by proposing a neural network-based feature selection method that focuses both on class discrimination and structure preservation in an integrated manner. In addition to assessing typical classification problems, we have investigated its effectiveness on band selection in hyperspectral images. Based on the results of the experiments, we may claim that the proposed feature/band selection can select a subset of features that is good for both classification and clustering.

Recently, several studies have claimed that using class-specific feature subsets provides certain advantages over using a single feature subset for representing the data for a classification problem. Unlike traditional feature selection methods, the class-specific feature selection methods select an optimal feature subset for each class. Typically class-specific feature selection (CSFS) methods use one-versus-all split of the data set that leads to issues such as class imbalance, decision aggregation, and high computational overhead. We propose a class-specific feature selection method embedded in a fuzzy rule-based classifier, which is free from the drawbacks associated with most existing class-specific methods. Additionally, our method can be adapted to control the level of redundancy in the class-specific feature subsets by adding a suitable regularizer to the learning objective. Our method results in class-specific rules involving class-specific subsets. We also propose an extension where different rules of a particular class are defined by different feature subsets to model different substructures within the class. The effectiveness of the proposed method has been validated through experiments on three synthetic data sets.

A major limitation of fuzzy or neuro-fuzzy systems is their failure to deal with high-dimensional datasets. This happens primarily due to the use of T-norm, particularly, product or minimum (or a softer version of it). Thus, there are hardly any work dealing with datasets with dimensions more than hundred or so. Here, we propose a neuro-fuzzy framework that can handle datasets with dimensions even more than 7000! In this context, we propose an adaptive softmin (Ada-softmin) which effectively overcomes the drawbacks of ``numeric underflow" and ``fake minimum" that arise for existing fuzzy systems while dealing with high-dimensional problems. We call it an Adaptive Takagi-Sugeno-Kang (AdaTSK) fuzzy system. We then equip the AdaTSK system to perform feature selection and rule extraction in an integrated manner. In this context, a novel gate function is introduced and embedded only in the consequent parts, which can determine the useful features and rules, in two successive phases of learning. Unlike conventional fuzzy rule bases, we design an enhanced fuzzy rule base (En-FRB), which maintains adequate rules but does not grow the number of rules exponentially with dimension that typically happens for fuzzy neural networks. The integrated Feature Selection and Rule Extraction AdaTSK (FSRE-AdaTSK) system consists of three sequential phases: (i) feature selection, (ii) rule extraction, and (iii) fine tuning. The effectiveness of the FSRE-AdaTSK is demonstrated on 19 datasets of which five are in more than 2000 dimension including two with dimension greater than 7000. This may be the first time fuzzy systems are realized for classification involving more than 7000 input features.