The accurate classification of lymphoma subtypes using hematoxylin and eosin (H&E)-stained tissue is complicated by the wide range of morphological features these cancers can exhibit. We present LymphoML - an interpretable machine learning method that identifies morphologic features that correlate with lymphoma subtypes. Our method applies steps to process H&E-stained tissue microarray cores, segment nuclei and cells, compute features encompassing morphology, texture, and architecture, and train gradient-boosted models to make diagnostic predictions. LymphoML's interpretable models, developed on a limited volume of H&E-stained tissue, achieve non-inferior diagnostic accuracy to pathologists using whole-slide images and outperform black box deep-learning on a dataset of 670 cases from Guatemala spanning 8 lymphoma subtypes. Using SHapley Additive exPlanation (SHAP) analysis, we assess the impact of each feature on model prediction and find that nuclear shape features are most discriminative for DLBCL (F1-score: 78.7%) and classical Hodgkin lymphoma (F1-score: 74.5%). Finally, we provide the first demonstration that a model combining features from H&E-stained tissue with features from a standardized panel of 6 immunostains results in a similar diagnostic accuracy (85.3%) to a 46-stain panel (86.1%).

Machine learning research has long focused on models rather than datasets, and prominent datasets are used for common ML tasks without regard to the breadth, difficulty, and faithfulness of the underlying problems. Neglecting the fundamental importance of data has given rise to inaccuracy, bias, and fragility in real-world applications, and research is hindered by saturation across existing dataset benchmarks. In response, we present DataPerf, a community-led benchmark suite for evaluating ML datasets and data-centric algorithms. We aim to foster innovation in data-centric AI through competition, comparability, and reproducibility. We enable the ML community to iterate on datasets, instead of just architectures, and we provide an open, online platform with multiple rounds of challenges to support this iterative development. The first iteration of DataPerf contains five benchmarks covering a wide spectrum of data-centric techniques, tasks, and modalities in vision, speech, acquisition, debugging, and diffusion prompting, and we support hosting new contributed benchmarks from the community. The benchmarks, online evaluation platform, and baseline implementations are open source, and the MLCommons Association will maintain DataPerf to ensure long-term benefits to academia and industry.

This work introduces a model that can recognize objects in images even if no training data is available for the object class. The only necessary knowledge about unseen categories comes from unsupervised text corpora. Unlike previous zero-shot learning models, which can only differentiate between unseen classes, our model can operate on a mixture of objects, simultaneously obtaining state of the art performance on classes with thousands of training images and reasonable performance on unseen classes. This is achieved by seeing the distributions of words in texts as a semantic space for understanding what objects look like. Our deep learning model does not require any manually defined semantic or visual features for either words or images.

Identifying patients who will be discharged within 24 hours can improve hospital resource management and quality of care. We studied this problem using eight years of Electronic Health Records (EHR) data from Stanford Hospital. We fit models to predict 24 hour discharge across the entire inpatient population. The best performing models achieved an area under the receiver-operator characteristic curve (AUROC) of 0.85 and an AUPRC of 0.53 on a held out test set. This model was also well calibrated. Finally, we analyzed the utility of this model in a decision theoretic framework to identify regions of ROC space in which using the model increases expected utility compared to the trivial always negative or always positive classifiers.

Personalized probabilistic forecasts of time to event (such as mortality) can be crucial in decision making, especially in the clinical setting. Inspired by ideas from the meteorology literature, we approach this problem through the paradigm of maximizing sharpness of prediction distributions, subject to calibration. In regression problems, it has been shown that optimizing the continuous ranked probability score (CRPS) instead of maximum likelihood leads to sharper prediction distributions while maintaining calibration. We introduce the Survival-CRPS, a generalization of the CRPS to the time to event setting, and present right-censored and interval-censored variants. To holistically evaluate the quality of predicted distributions over time to event, we present the Survival-AUPRC evaluation metric, an analog to area under the precision-recall curve. We apply these ideas by building a recurrent neural network for mortality prediction, using an Electronic Health Record dataset covering millions of patients. We demonstrate significant benefits in models trained by the Survival-CRPS objective instead of maximum likelihood.

Improving the quality of end-of-life care for hospitalized patients is a priority for healthcare organizations. Studies have shown that physicians tend to over-estimate prognoses, which in combination with treatment inertia results in a mismatch between patients wishes and actual care at the end of life. We describe a method to address this problem using Deep Learning and Electronic Health Record (EHR) data, which is currently being piloted, with Institutional Review Board approval, at an academic medical center. The EHR data of admitted patients are automatically evaluated by an algorithm, which brings patients who are likely to benefit from palliative care services to the attention of the Palliative Care team. The algorithm is a Deep Neural Network trained on the EHR data from previous years, to predict all-cause 3-12 month mortality of patients as a proxy for patients that could benefit from palliative care. Our predictions enable the Palliative Care team to take a proactive approach in reaching out to such patients, rather than relying on referrals from treating physicians, or conduct time consuming chart reviews of all patients. We also present a novel interpretation technique which we use to provide explanations of the model's predictions.

This is the Proceedings of the Twenty-Fifth Conference on Uncertainty in Artificial Intelligence, which was held in Montreal, QC, Canada, June 18 - 21 2009.

A common problem in knowledge representation and related fields is reasoning over a large joint knowledge graph, represented as triples of a relation between two entities. The goal of this paper is to develop a more powerful neural network model suitable for inference over these relationships. Previous models suffer from weak interaction between entities or simple linear projection of the vector space. We address these problems by introducing a neural tensor network (NTN) model which allow the entities and relations to interact multiplicatively. Additionally, we observe that such knowledge base models can be further improved by representing each entity as the average of vectors for the words in the entity name, giving an additional dimension of similarity by which entities can share statistical strength. We assess the model by considering the problem of predicting additional true relations between entities given a partial knowledge base. Our model outperforms previous models and can classify unseen relationships in WordNet and FreeBase with an accuracy of 86.2% and 90.0%, respectively.

This work introduces a model that can recognize objects in images even if no training data is available for the object class. The only necessary knowledge about unseen visual categories comes from unsupervised text corpora. Unlike previous zero-shot learning models, which can only differentiate between unseen classes, our model can operate on a mixture of seen and unseen classes, simultaneously obtaining state of the art performance on classes with thousands of training images andreasonable performance on unseen classes. This is achieved by seeing the distributions of words in texts as a semantic space for understanding what objects looklike. Our deep learning model does not require any manually defined semantic or visual features for either words or images. Images are mapped to be close to semantic word vectors corresponding to their classes, and the resulting image embeddings can be used to distinguish whether an image is of a seen or unseen class.We then use novelty detection methods to differentiate unseen classes from seen classes. We demonstrate two novelty detection strategies; the first gives high accuracy on unseen classes, while the second is conservative in its prediction of novelty and keeps the seen classes' accuracy high.

In massive open online courses (MOOCs), peer grading serves as a critical tool for scaling the grading of complex, open-ended assignments to courses with tens or hundreds of thousands of students. But despite promising initial trials, it does not always deliver accurate results compared to human experts. In this paper, we develop algorithms for estimating and correcting for grader biases and reliabilities, showing significant improvement in peer grading accuracy on real data with 63,199 peer grades from Coursera's HCI course offerings --- the largest peer grading networks analysed to date. We relate grader biases and reliabilities to other student factors such as student engagement, performance as well as commenting style. We also show that our model can lead to more intelligent assignment of graders to gradees.