Corresponding author: Dr Joseph Jacob UCL Centre for Medical Image Computing 1st Floor, 90 High Holborn, London WC1V6LJ j.jacob@ucl.ac.uk Abstract Early detection and diagnosis of coronary artery disease (CAD) could save lives and reduce healthcare costs. In this study, we propose a 3D Resnet-50 deep learning model to directly classify normal subjects and CAD patients on computed tomography coronary angiography images. Our proposed method outperforms a 2D Resnet-50 model by 23.65%. Explainability is also provided by using a Grad-GAM. Furthermore, we link the 3D CAD classification to a 2D two-class semantic segmentation for improved explainability and accurate abnormality localisation. Introduction Coronary artery disease (CAD) is a common cause of death [1] in developed (i.e., UK, USA) and developing countries (i.e., India, Philippines). Early detection and diagnosis of CAD could save lives and costs [2]. Currently, computed tomography coronary angiography (CTCA) plays a central role in diagnosing or excluding CAD in patients with chest pain [3, 4].

Abstractive dialogue summarization has long been viewed as an important standalone task in natural language processing, but no previous work has explored the possibility of whether abstractive dialogue summarization can also be used as a means to boost an NLP system's performance on other important dialogue comprehension tasks. In this paper, we propose a novel type of dialogue summarization task - STRUctured DiaLoguE Summarization - that can help pre-trained language models to better understand dialogues and improve their performance on important dialogue comprehension tasks. We further collect human annotations of STRUDEL summaries over 400 dialogues and introduce a new STRUDEL dialogue comprehension modeling framework that integrates STRUDEL into a graph-neural-network-based dialogue reasoning module over transformer encoder language models to improve their dialogue comprehension abilities. In our empirical experiments on two important downstream dialogue comprehension tasks - dialogue question answering and dialogue response prediction - we show that our STRUDEL dialogue comprehension model can significantly improve the dialogue comprehension performance of transformer encoder language models.

Factual inconsistencies in generated summaries severely limit the practical applications of abstractive dialogue summarization. Although significant progress has been achieved by using pre-trained models, substantial amounts of hallucinated content are found during the human evaluation. Pre-trained models are most commonly fine-tuned with cross-entropy loss for text summarization, which may not be an optimal strategy. In this work, we provide a typology of factual errors with annotation data to highlight the types of errors and move away from a binary understanding of factuality. We further propose a training strategy that improves the factual consistency and overall quality of summaries via a novel contrastive fine-tuning, called ConFiT. Based on our linguistically-informed typology of errors, we design different modular objectives that each target a specific type. Specifically, we utilize hard negative samples with errors to reduce the generation of factual inconsistency. In order to capture the key information between speakers, we also design a dialogue-specific loss. Using human evaluation and automatic faithfulness metrics, we show that our model significantly reduces all kinds of factual errors on the dialogue summarization, SAMSum corpus. Moreover, our model could be generalized to the meeting summarization, AMI corpus, and it produces significantly higher scores than most of the baselines on both datasets regarding word-overlap metrics.

MC Dropout is a mainstream "free lunch" method in medical imaging for approximate Bayesian computations (ABC). Its appeal is to solve out-of-the-box the daunting task of ABC and uncertainty quantification in Neural Networks (NNs); to fall within the variational inference (VI) framework; and to propose a highly multimodal, faithful predictive posterior. We question the properties of MC Dropout for approximate inference, as in fact MC Dropout changes the Bayesian model; its predictive posterior assigns $0$ probability to the true model on closed-form benchmarks; the multimodality of its predictive posterior is not a property of the true predictive posterior but a design artefact. To address the need for VI on arbitrary models, we share a generic VI engine within the pytorch framework. The code includes a carefully designed implementation of structured (diagonal plus low-rank) multivariate normal variational families, and mixtures thereof. It is intended as a go-to no-free-lunch approach, addressing shortcomings of mean-field VI with an adjustable trade-off between expressivity and computational complexity.

Datasets are rarely a realistic approximation of the target population. Say, prevalence is misrepresented, image quality is above clinical standards, etc. This mismatch is known as sampling bias. Sampling biases are a major hindrance for machine learning models. They cause significant gaps between model performance in the lab and in the real world. Our work is a solution to prevalence bias. Prevalence bias is the discrepancy between the prevalence of a pathology and its sampling rate in the training dataset, introduced upon collecting data or due to the practioner rebalancing the training batches. This paper lays the theoretical and computational framework for training models, and for prediction, in the presence of prevalence bias. Concretely a bias-corrected loss function, as well as bias-corrected predictive rules, are derived under the principles of Bayesian risk minimization. The loss exhibits a direct connection to the information gain. It offers a principled alternative to heuristic training losses and complements test-time procedures based on selecting an operating point from summary curves. It integrates seamlessly in the current paradigm of (deep) learning using stochastic backpropagation and naturally with Bayesian models.

Numerous lung diseases, such as idiopathic pulmonary fibrosis (IPF), exhibit dilation of the airways. Accurate measurement of dilatation enables assessment of the progression of disease. Unfortunately the combination of image noise and airway bifurcations causes high variability in the profiles of cross-sectional areas, rendering the identification of affected regions very difficult. Here we introduce a noise-robust method for automatically detecting the location of progressive airway dilatation given two profiles of the same airway acquired at different time points. We propose a probabilistic model of abrupt relative variations between profiles and perform inference via Reversible Jump Markov Chain Monte Carlo sampling. We demonstrate the efficacy of the proposed method on two datasets; (i) images of healthy airways with simulated dilatation; (ii) pairs of real images of IPF-affected airways acquired at 1 year intervals. Our model is able to detect the starting location of airway dilatation with an accuracy of 2.5mm on simulated data. The experiments on the IPF dataset display reasonable agreement with radiologists. We can compute a relative change in airway volume that may be useful for quantifying IPF disease progression.