The significant portion of diabetic patients was affected due to major blindness caused by Diabetic retinopathy (DR). For diabetic retinopathy, lesion segmentation, and detection the comprehensive examination is delved into the deep learning techniques application. The study conducted a systematic literature review using the PRISMA analysis and 62 articles has been investigated in the research. By including CNN-based models for DR grading, and feature fusion several deep-learning methodologies are explored during the study. For enhancing effectiveness in classification accuracy and robustness the data augmentation and ensemble learning strategies are scrutinized. By demonstrating the superior performance compared to individual models the efficacy of ensemble learning methods is investigated. The potential ensemble approaches in DR diagnosis are shown by the integration of multiple pre-trained networks with custom classifiers that yield high specificity. The diverse deep-learning techniques that are employed for detecting DR lesions are discussed within the diabetic retinopathy lesions segmentation and detection section. By emphasizing the requirement for continued research and integration into clinical practice deep learning shows promise for personalized healthcare and early detection of diabetics.

This groundbreaking study explores the expanse of Large Language Models (LLMs), such as Generative Pre-Trained Transformer (GPT) and Bidirectional Encoder Representations from Transformers (BERT) across varied domains ranging from technology, finance, healthcare to education. Despite their established prowess in Natural Language Processing (NLP), these LLMs have not been systematically examined for their impact on domains such as fitness, and holistic well-being, urban planning, climate modelling as well as disaster management. This review paper, in addition to furnishing a comprehensive analysis of the vast expanse and extent of LLMs' utility in diverse domains, recognizes the research gaps and realms where the potential of LLMs is yet to be harnessed. This study uncovers innovative ways in which LLMs can leave a mark in the fields like fitness and wellbeing, urban planning, climate modelling and disaster response which could inspire future researches and applications in the said avenues.