AI is demanding an evergrowing portion of environmental resources. Despite their potential impact on AI environmental sustainability, the role that programming languages play in AI (in)efficiency is to date still unknown. With this study, we aim to understand the impact that programming languages can have on AI environmental sustainability. To achieve our goal, we conduct a controlled empirical experiment by considering five programming languages (C++, Java, Python, MATLAB, and R), seven AI algorithms (KNN, SVC, AdaBoost, decision tree, logistic regression, naive bayses, and random forest), three popular datasets, and the training and inference phases. The collected results show that programming languages have a considerable impact on AI environmental sustainability. Compiled and semi-compiled languages (C++, Java) consistently consume less than interpreted languages (Python, MATLAB, R), which require up to 54x more energy. Some languages are cumulatively more efficient in training, while others in inference. Which programming language consumes the most highly depends on the algorithm considered. Ultimately, algorithm implementation might be the most determining factor in Green AI, regardless of the language used. As conclusion, while making AI more environmentally sustainable is paramount, a trade-off between energy efficiency and implementation ease should always be considered. Green AI can be achieved without the need of completely disrupting the development practices and technologies currently in place.

The increasing availability of biomedical data is helping to design more robust deep learning (DL) algorithms to analyze biomedical samples. Currently, one of the main limitations to train DL algorithms to perform a specific task is the need for medical experts to label data. Automatic methods to label data exist, however automatic labels can be noisy and it is not completely clear when automatic labels can be adopted to train DL models. This paper aims to investigate under which circumstances automatic labels can be adopted to train a DL model on the classification of Whole Slide Images (WSI). The analysis involves multiple architectures, such as Convolutional Neural Networks (CNN) and Vision Transformer (ViT), and over 10000 WSIs, collected from three use cases: celiac disease, lung cancer and colon cancer, which one including respectively binary, multiclass and multilabel data. The results allow identifying 10% as the percentage of noisy labels that lead to train competitive models for the classification of WSIs. Therefore, an algorithm generating automatic labels needs to fit this criterion to be adopted. The application of the Semantic Knowledge Extractor Tool (SKET) algorithm to generate automatic labels leads to performance comparable to the one obtained with manual labels, since it generates a percentage of noisy labels between 2-5%. Automatic labels are as effective as manual ones, reaching solid performance comparable to the one obtained training models with manual labels.