Biological neurons have a variety of intrinsic properties because of the large number of voltage dependent currents that control their activity. Neuromodulatory substances modify both the balance of conductances that determine intrinsic properties and the strength of synapses. These mechanisms alter circuit dynamics, and suggest that functional circuits exist only in the modulatory environment in which they operate. 1 INTRODUCTION Many studies of artificial neural networks employ model neurons and synapses that are considerably simpler than their biological counterparts.

Biological neurons have a variety of intrinsic properties because of the large number of voltage dependent currents that control their activity. Neuromodulatory substances modify both the balance of conductances that determine intrinsic properties and the strength of synapses. These mechanisms alter circuit dynamics, and suggest that functional circuits exist only in the modulatory environment in which they operate. 1 INTRODUCTION Many studies of artificial neural networks employ model neurons and synapses that are considerably simpler than their biological counterparts.

We demonstrate the use of a digital signal processing board to construct hybrid networks consisting of computer model neurons connected to a biological neural network. This system operates in real time.

We demonstrate the use of a digital signal processing board to construct hybrid networks consisting of computer model neurons connected to a biological neural network. This system operates in real time.