Semantic segmentation has a wide array of applications ranging from medical-image analysis, scene understanding, autonomous driving and robotic navigation. This work deals with medical image segmentation and in particular with accurate polyp detection and segmentation during colonoscopy examinations. Several convolutional neural network architectures have been proposed to effectively deal with this task and with the problem of segmenting objects at different scale input. The basic architecture in image segmentation consists of an encoder and a decoder: the first uses convolutional filters to extract features from the image, the second is responsible for generating the final output. In this work, we compare some variant of the DeepLab architecture obtained by varying the decoder backbone. We compare several decoder architectures, including ResNet, Xception, EfficentNet, MobileNet and we perturb their layers by substituting ReLU activation layers with other functions. The resulting methods are used to create deep ensembles which are shown to be very effective. Our experimental evaluations show that our best ensemble produces good segmentation results by achieving high evaluation scores with a dice coefficient of 0.884, and a mean Intersection over Union (mIoU) of 0.818 for the Kvasir-SEG dataset. To improve reproducibility and research efficiency the MATLAB source code used for this research is available at GitHub: https://github.com/LorisNanni.

Recently, much attention has been devoted to finding highly efficient and powerful activation functions for CNN layers. Because activation functions inject different nonlinearities between layers that affect performance, varying them is one method for building robust ensembles of CNNs. The objective of this study is to examine the performance of CNN ensembles made with different activation functions, including six new ones presented here: 2D Mexican ReLU, TanELU, MeLU+GaLU, Symmetric MeLU, Symmetric GaLU, and Flexible MeLU. The highest performing ensemble was built with CNNs having different activation layers that randomly replaced the standard ReLU. A comprehensive evaluation of the proposed approach was conducted across fifteen biomedical data sets representing various classification tasks. The proposed method was tested on two basic CNN architectures: Vgg16 and ResNet50. Results demonstrate the superiority in performance of this approach. The MATLAB source code for this study will be available at https://github.com/LorisNanni.

Stochastic gradient descent (SGD) is the main approach for training deep networks: it moves towards the optimum of the cost function by iteratively updating the parameters of a model in the direction of the gradient of the loss evaluated on a minibatch. Several variants of SGD have been proposed to make adaptive step sizes for each parameter (adaptive gradient) and take into account the previous updates (momentum). Among several alternative of SGD the most popular are AdaGrad, AdaDelta, RMSProp and Adam which scale coordinates of the gradient by square roots of some form of averaging of the squared coordinates in the past gradients and automatically adjust the learning rate on a parameter basis. In this work, we compare Adam based variants based on the difference between the present and the past gradients, the step size is adjusted for each parameter. We run several tests benchmarking proposed methods using medical image data. The experiments are performed using ResNet50 architecture neural network. Moreover, we have tested ensemble of networks and the fusion with ResNet50 trained with stochastic gradient descent. To combine the set of ResNet50 the simple sum rule has been applied. Proposed ensemble obtains very high performance, it obtains accuracy comparable or better than actual state of the art. To improve reproducibility and research efficiency the MATLAB source code used for this research is available at GitHub: https://github.com/LorisNanni.

Classification of biological images is an important task with crucial application in many fields, such as cell phenotypes recognition, detection of cell organelles and histopathological classification, and it might help in early medical diagnosis, allowing automatic disease classification without the need of a human expert. In this paper we classify biomedical images using ensembles of neural networks. We create this ensemble using a ResNet50 architecture and modifying its activation layers by substituting ReLUs with other functions. We select our activations among the following ones: ReLU, leaky ReLU, Parametric ReLU, ELU, Adaptive Piecewice Linear Unit, S-Shaped ReLU, Swish , Mish, Mexican Linear Unit, Gaussian Linear Unit, Parametric Deformable Linear Unit, Soft Root Sign (SRS) and others. As a baseline, we used an ensemble of neural networks that only use ReLU activations. We tested our networks on several small and medium sized biomedical image datasets. Our results prove that our best ensemble obtains a better performance than the ones of the naive approaches. In order to encourage the reproducibility of this work, the MATLAB code of all the experiments will be shared at https://github.com/LorisNanni.