Accurate and automated gland segmentation on pathological images can assist pathologists in diagnosing the malignancy of colorectal adenocarcinoma. However, due to various gland shapes, severe deformation of malignant glands, and overlapping adhesions between glands. Gland segmentation has always been very challenging. To address these problems, we propose a DEA model. This model consists of two branches: the backbone encoding and decoding network and the local semantic extraction network. The backbone encoding and decoding network extracts advanced Semantic features, uses the proposed feature decoder to restore feature space information, and then enhances the boundary features of the gland through boundary enhancement attention. The local semantic extraction network uses the pre-trained DeepLabv3+ as a Local semantic-guided encoder to realize the extraction of edge features. Experimental results on two public datasets, GlaS and CRAG, confirm that the performance of our method is better than other gland segmentation methods.

Mitosis detection is one of the challenging problems in computational pathology, and mitotic count is an important index of cancer grading for pathologists. However, current counts of mitotic nuclei rely on pathologists looking microscopically at the number of mitotic nuclei in hot spots, which is subjective and time-consuming. In this paper, we propose a two-stage cascaded network, named FoCasNet, for mitosis detection. In the first stage, a detection network named M_det is proposed to detect as many mitoses as possible. In the second stage, a classification network M_class is proposed to refine the results of the first stage. In addition, the attention mechanism, normalization method, and hybrid anchor branch classification subnet are introduced to improve the overall detection performance. Our method achieves the current highest F1-score of 0.888 on the public dataset ICPR 2012. We also evaluated our method on the GZMH dataset released by our research team for the first time and reached the highest F1-score of 0.563, which is also better than multiple classic detection networks widely used at present. It confirmed the effectiveness and generalization of our method. The code will be available at: https://github.com/antifen/mitosis-nuclei-detection.

Mitosis nuclei count is one of the important indicators for the pathological diagnosis of breast cancer. The manual annotation needs experienced pathologists, which is very time-consuming and inefficient. With the development of deep learning methods, some models with good performance have emerged, but the generalization ability should be further strengthened. In this paper, we propose a two-stage mitosis segmentation and classification method, named SCMitosis. Firstly, the segmentation performance with a high recall rate is achieved by the proposed depthwise separable convolution residual block and channel-spatial attention gate. Then, a classification network is cascaded to further improve the detection performance of mitosis nuclei. The proposed model is verified on the ICPR 2012 dataset, and the highest F-score value of 0.8687 is obtained compared with the current state-of-the-art algorithms. In addition, the model also achieves good performance on GZMH dataset, which is prepared by our group and will be firstly released with the publication of this paper.

Accelerating deep neural networks (DNNs) has been attracting increasing attention as it can benefit a wide range of applications, e.g., enabling mobile systems with limited computing resources to own powerful visual recognition ability. A practical strategy to this goal usually relies on a two-stage process: operating on the trained DNNs (e.g., approximating the convolutional filters with tensor decomposition) and fine-tuning the amended network, leading to difficulty in balancing the trade-off between acceleration and maintaining recognition performance. In this work, aiming at a general and comprehensive way for neural network acceleration, we develop a Wavelet-like Auto-Encoder (WAE) that decomposes the original input image into two low-resolution channels (sub-images) and incorporate the WAE into the classification neural networks for joint training. The two decomposed channels, in particular, are encoded to carry the low-frequency information (e.g., image profiles) and high-frequency (e.g., image details or noises), respectively, and enable reconstructing the original input image through the decoding process. Then, we feed the low-frequency channel into a standard classification network such as VGG or ResNet and employ a very lightweight network to fuse with the high-frequency channel to obtain the classification result. Compared to existing DNN acceleration solutions, our framework has the following advantages: i) it is tolerant to any existing convolutional neural networks for classification without amending their structures; ii) the WAE provides an interpretable way to preserve the main components of the input image for classification.