The necessity of achieving an effective balance between minimizing the losses associated with restricting human mobility and ensuring hospital capacity has gained significant attention in the aftermath of COVID-19. Reinforcement learning (RL)-based strategies for human mobility management have recently advanced in addressing the dynamic evolution of cities and epidemics; however, they still face challenges in achieving coordinated control at the township level and adapting to cities of varying scales. To address the above issues, we propose a multi-agent RL approach that achieves Pareto optimality in managing hospital capacity and human mobility (H2-MARL), applicable across cities of different scales. We first develop a township-level infection model with online-updatable parameters to simulate disease transmission and construct a city-wide dynamic spatiotemporal epidemic simulator. On this basis, H2-MARL is designed to treat each division as an agent, with a trade-off dual-objective reward function formulated and an experience replay buffer enriched with expert knowledge built. To evaluate the effectiveness of the model, we construct a township-level human mobility dataset containing over one billion records from four representative cities of varying scales. Extensive experiments demonstrate that H2-MARL has the optimal dual-objective trade-off capability, which can minimize hospital capacity strain while minimizing human mobility restriction loss. Meanwhile, the applicability of the proposed model to epidemic control in cities of varying scales is verified, which showcases its feasibility and versatility in practical applications.

Online continual learning (OCL), which enables AI systems to adaptively learn from non-stationary data streams, is commonly achieved using experience replay (ER)-based methods that retain knowledge by replaying stored past during training. However, these methods face challenges of prediction bias, stemming from deviations in parameter update directions during task transitions. This paper identifies parameter variation imbalance as a critical factor contributing to prediction bias in ER-based OCL. Specifically, using the proposed parameter variation evaluation method, we highlight two types of imbalance: correlation-induced imbalance, where certain parameters are disproportionately updated across tasks, and layer-wise imbalance, where output layer parameters update faster than those in preceding layers. To mitigate the above imbalances, we propose the Parameter Variation Balancing Framework (PVBF), which incorporates: 1) a novel method to compute parameter correlations with previous tasks based on parameter variations, 2) an encourage-and-consolidate (E&C) method utilizing parameter correlations to perform gradient adjustments across all parameters during training, 3) a dual-layer copy weights with reinit (D-CWR) strategy to slowly update output layer parameters for frequently occuring sample categories. Experiments on short and long task sequences demonstrate that PVBF significantly reduces prediction bias and improves OCL performance, achieving up to 47\% higher accuracy compared to existing ER-based methods.