Despite the growing interest in human-AI decision making, experimental studies with domain experts remain rare, largely due to the complexity of working with domain experts and the challenges in setting up realistic experiments. In this work, we conduct an in-depth collaboration with radiologists in prostate cancer diagnosis based on MRI images. Building on existing tools for teaching prostate cancer diagnosis, we develop an interface and conduct two experiments to study how AI assistance and performance feedback shape the decision making of domain experts. In Study 1, clinicians were asked to provide an initial diagnosis (human), then view the AI's prediction, and subsequently finalize their decision (human-AI team). In Study 2 (after a memory wash-out period), the same participants first received aggregated performance statistics from Study 1, specifically their own performance, the AI's performance, and their human-AI team performance, and then directly viewed the AI's prediction before making their diagnosis (i.e., no independent initial diagnosis). These two workflows represent realistic ways that clinical AI tools might be used in practice, where the second study simulates a scenario where doctors can adjust their reliance and trust on AI based on prior performance feedback. Our findings show that, while human-AI teams consistently outperform humans alone, they still underperform the AI due to under-reliance, similar to prior studies with crowdworkers. Providing clinicians with performance feedback did not significantly improve the performance of human-AI teams, although showing AI decisions in advance nudges people to follow AI more. Meanwhile, we observe that the ensemble of human-AI teams can outperform AI alone, suggesting promising directions for human-AI collaboration.

Virtual screening aims to find desirable compounds from chemical library by using computational methods. For this purpose with machine learning, model outputs that can be interpreted as predictive probability will be beneficial, in that a high prediction score corresponds to high probability of correctness. In this work, we present a study on the prediction performance and reliability of graph neural networks trained with the recently proposed Bayesian learning algorithms. Our work shows that Bayesian learning algorithms allow well-calibrated predictions for various GNN architectures and classification tasks. Also, we show the implications of reliable predictions on virtual screening, where Bayesian learning may lead to higher success in finding hit compounds.