Nested pairwise frames is a method for relative benchmarking of cell or tissue digital pathology models against manual pathologist annotations on a set of sampled patches. At a high level, the method compares agreement between a candidate model and pathologist annotations with agreement among pathologists' annotations. This evaluation framework addresses fundamental issues of data size and annotator variability in using manual pathologist annotations as a source of ground truth for model validation. We implemented nested pairwise frames evaluation for tissue classification, cell classification, and cell count prediction tasks and show results for cell and tissue models deployed on an H&E-stained melanoma dataset.

Given the high power density low discharge rate and decreasing cost rechargeable lithium-ion batteries LiBs have found a wide range of applications such as power grid level storage systems electric vehicles and mobile devices. Developing a framework to accurately model the nonlinear degradation process of LiBs which is indeed a supervised learning problem becomes an important research topic. This paper presents a classical-quantum hybrid machine learning approach to capture the LiB degradation model that assesses battery cell life loss from operating profiles. Our work is motivated by recent advances in quantum computers as well as the similarity between neural networks and quantum circuits. Similar to adjusting weight parameters in conventional neural networks the parameters of the quantum circuit namely the qubits degree of freedom can be tuned to learn a nonlinear function in a supervised learning fashion. As a proof of concept paper our obtained numerical results with the battery dataset provided by NASA demonstrate the ability of the quantum neural networks in modeling the nonlinear relationship between the degraded capacity and the operating cycles. We also discuss the potential advantage of the quantum approach compared to conventional neural networks in classical computers in dealing with massive data especially in the context of future penetration of EVs and energy storage.