Previous work on clinical relation extraction from free-text sentences leveraged information about semantic types from clinical knowledge bases as a part of entity representations. In this paper, we exploit additional evidence by also making use of domain-specific semantic type dependencies. We encode the relation between a span of tokens matching a Unified Medical Language System (UMLS) concept and other tokens in the sentence. We implement our method and compare against different named entity recognition (NER) architectures (i.e., BiLSTM-CRF and BiLSTM-GCN-CRF) using different pre-trained clinical embeddings (i.e., BERT, BioBERT, UMLSBert). Our experimental results on clinical datasets show that in some cases NER effectiveness can be significantly improved by making use of domain-specific semantic type dependencies. Our work is also the first study generating a matrix encoding to make use of more than three dependencies in one pass for the NER task.

Large-language models are capable of completing a variety of tasks, but remain unpredictable and intractable. Representation engineering seeks to resolve this problem through a new approach utilizing samples of contrasting inputs to detect and edit high-level representations of concepts such as honesty, harmfulness or power-seeking. We formalize the goals and methods of representation engineering to present a cohesive picture of work in this emerging discipline. We compare it with alternative approaches, such as mechanistic interpretability, prompt-engineering and fine-tuning. We outline risks such as performance decrease, compute time increases and steerability issues. We present a clear agenda for future research to build predictable, dynamic, safe and personalizable LLMs.

Can ChatGPT diagnose Alzheimer's Disease (AD)? AD is a devastating neurodegenerative condition that affects approximately 1 in 9 individuals aged 65 and older, profoundly impairing memory and cognitive function. This paper utilises 9300 electronic health records (EHRs) with data from Magnetic Resonance Imaging (MRI) and cognitive tests to address an intriguing question: As a general-purpose task solver, can ChatGPT accurately detect AD using EHRs? We present an in-depth evaluation of ChatGPT using a black-box approach with zero-shot and multi-shot methods. This study unlocks ChatGPT's capability to analyse MRI and cognitive test results, as well as its potential as a diagnostic tool for AD. By automating aspects of the diagnostic process, this research opens a transformative approach for the healthcare system, particularly in addressing disparities in resource-limited regions where AD specialists are scarce. Hence, it offers a foundation for a promising method for early detection, supporting individuals with timely interventions, which is paramount for Quality of Life (QoL).

As LLMs develop increasingly advanced capabilities, there is an increased need to minimize the harm that could be caused to society by certain model outputs; hence, most LLMs have safety guardrails added, for example via fine-tuning. In this paper, we argue the position that current safety fine-tuning is very similar to a traditional cat-and-mouse game (or arms race) between attackers and defenders in cybersecurity. Model jailbreaks and attacks are patched with bandaids to target the specific attack mechanism, but many similar attack vectors might remain. When defenders are not proactively coming up with principled mechanisms, it becomes very easy for attackers to sidestep any new defenses. We show how current defenses are insufficient to prevent new adversarial jailbreak attacks, reward hacking, and loss of control problems. In order to learn from past mistakes in cybersecurity, we draw analogies with historical examples and develop lessons learned that can be applied to LLM safety. These arguments support the need for new and more principled approaches to designing safe models, which are architected for security from the beginning. We describe several such approaches from the AI literature.

With the rapid adoption of Internet technologies, digital footprints have become ubiquitous and versatile to revolutionise the financial industry in digital transformation. This paper takes initiatives to investigate a new paradigm of the unified credit assessment with the use of federated artificial intelligence. We conceptualised digital human representation which consists of social, contextual, financial and technological dimensions to assess the commercial creditworthiness and social reputation of both banked and unbanked individuals. A federated artificial intelligence platform is proposed with a comprehensive set of system design for efficient and effective credit scoring. The study considerably contributes to the cumulative development of financial intelligence and social computing. It also provides a number of implications for academic bodies, practitioners, and developers of financial technologies.

In this paper, we propose a novel supervised learning method that is called Deep Embedding Kernel (DEK). DEK combines the advantages of deep learning and kernel methods in a unified framework. More specifically, DEK is a learnable kernel represented by a newly designed deep architecture. Compared with pre-defined kernels, this kernel can be explicitly trained to map data to an optimized high-level feature space where data may have favorable features toward the application. Compared with typical deep learning using SoftMax or logistic regression as the top layer, DEK is expected to be more generalizable to new data. Experimental results show that DEK has superior performance than typical machine learning methods in identity detection, classification, regression, dimension reduction, and transfer learning.