3D generative models have shown significant promise in structure-based drug design (SBDD), particularly in discovering ligands tailored to specific target binding sites. Existing algorithms often focus primarily on ligand-target binding, characterized by binding affinity. Moreover, models trained solely on target-ligand distribution may fall short in addressing the broader objectives of drug discovery, such as the development of novel ligands with desired properties like drug-likeness, and synthesizability, underscoring the multifaceted nature of the drug design process. To overcome these challenges, we decouple the problem into molecular generation and property prediction. The latter synergistically guides the diffusion sampling process, facilitating guided diffusion and resulting in the creation of meaningful molecules with the desired properties. We call this guided molecular generation process as TAGMol. Through experiments on benchmark datasets, TAGMol demonstrates superior performance compared to state-of-the-art baselines, achieving a 22% improvement in average Vina Score and yielding favorable outcomes in essential auxiliary properties. This establishes TAGMol as a comprehensive framework for drug generation.

In the e-commerce domain, the accurate extraction of attribute-value pairs from product listings (e.g., Brand: Apple) is crucial for enhancing search and recommendation systems. The automation of this extraction process is challenging due to the vast diversity of product categories and their respective attributes, compounded by the lack of extensive, accurately annotated training datasets and the demand for low latency to meet the real-time needs of e-commerce platforms. To address these challenges, we introduce GenToC, a novel two-stage model for extracting attribute-value pairs from product titles. GenToC is designed to train with partially-labeled data, leveraging incomplete attribute-value pairs and obviating the need for a fully annotated dataset. Moreover, we introduce a bootstrapping method that enables GenToC to progressively refine and expand its training dataset. This enhancement substantially improves the quality of data available for training other neural network models that are typically faster but are inherently less capable than GenToC in terms of their capacity to handle partially-labeled data. By supplying an enriched dataset for training, GenToC significantly advances the performance of these alternative models, making them more suitable for real-time deployment. Our results highlight the unique capability of GenToC to learn from a limited set of labeled data and to contribute to the training of more efficient models, marking a significant leap forward in the automated extraction of attribute-value pairs from product titles. GenToC has been successfully integrated into India's largest B2B e-commerce platform, IndiaMART.com, achieving a significant increase of 21.1% in recall over the existing deployed system while maintaining a high precision of 89.5% in this challenging task.

Automated completion of open knowledge bases (Open KBs), which are constructed from triples of the form (subject phrase, relation phrase, object phrase), obtained via open information extraction (Open IE) system, are useful for discovering novel facts that may not be directly present in the text. However, research in Open KB completion (Open KBC) has so far been limited to resource-rich languages like English. Using the latest advances in multilingual Open IE, we construct the first multilingual Open KBC dataset, called mOKB6, containing facts from Wikipedia in six languages (including English). Improving the previous Open KB construction pipeline by doing multilingual coreference resolution and keeping only entity-linked triples, we create a dense Open KB. We experiment with several models for the task and observe a consistent benefit of combining languages with the help of shared embedding space as well as translations of facts. We also observe that current multilingual models struggle to remember facts seen in languages of different scripts.