The latest large language models (LLMs) such as ChatGPT, exhibit strong capabilities in automated mental health analysis. However, existing relevant studies bear several limitations, including inadequate evaluations, lack of prompting strategies, and ignorance of exploring LLMs for explainability. To bridge these gaps, we comprehensively evaluate the mental health analysis and emotional reasoning ability of LLMs on 11 datasets across 5 tasks. We explore the effects of different prompting strategies with unsupervised and distantly supervised emotional information. Based on these prompts, we explore LLMs for interpretable mental health analysis by instructing them to generate explanations for each of their decisions. We convey strict human evaluations to assess the quality of the generated explanations, leading to a novel dataset with 163 human-assessed explanations. We benchmark existing automatic evaluation metrics on this dataset to guide future related works. According to the results, ChatGPT shows strong in-context learning ability but still has a significant gap with advanced task-specific methods. Careful prompt engineering with emotional cues and expert-written few-shot examples can also effectively improve performance on mental health analysis. In addition, ChatGPT generates explanations that approach human performance, showing its great potential in explainable mental health analysis.

Many computational linguistic methods have been proposed to study the information content of languages. We consider two interesting research questions: 1) how is information distributed over long documents, and 2) how does content reduction, such as token selection and text summarization, affect the information density in long documents. We present four criteria for information density estimation for long documents, including surprisal, entropy, uniform information density, and lexical density. Among those criteria, the first three adopt the measures from information theory. We propose an attention-based word selection method for clinical notes and study machine summarization for multiple-domain documents. Our findings reveal the systematic difference in information density of long text in various domains. Empirical results on automated medical coding from long clinical notes show the effectiveness of the attention-based word selection method.

The context-aware emotional reasoning ability of AI systems, especially in conversations, is of vital importance in applications such as online opinion mining from social media and empathetic dialogue systems. Due to the implicit nature of conveying emotions in many scenarios, commonsense knowledge is widely utilized to enrich utterance semantics and enhance conversation modeling. However, most previous knowledge infusion methods perform empirical knowledge filtering and design highly customized architectures for knowledge interaction with the utterances, which can discard useful knowledge aspects and limit their generalizability to different knowledge sources. Based on these observations, we propose a Bipartite Heterogeneous Graph (BHG) method for enhancing emotional reasoning with commonsense knowledge. In BHG, the extracted context-aware utterance representations and knowledge representations are modeled as heterogeneous nodes. Two more knowledge aggregation node types are proposed to perform automatic knowledge filtering and interaction. BHG-based knowledge infusion can be directly generalized to multi-type and multi-grained knowledge sources. In addition, we propose a Multi-dimensional Heterogeneous Graph Transformer (MHGT) to perform graph reasoning, which can retain unchanged feature spaces and unequal dimensions for heterogeneous node types during inference to prevent unnecessary loss of information. Experiments show that BHG-based methods significantly outperform state-of-the-art knowledge infusion methods and show generalized knowledge infusion ability with higher efficiency. Further analysis proves that previous empirical knowledge filtering methods do not guarantee to provide the most useful knowledge information. Our code is available at: https://github.com/SteveKGYang/BHG.

Automated medical coding, an essential task for healthcare operation and delivery, makes unstructured data manageable by predicting medical codes from clinical documents. Recent advances in deep learning and natural language processing have been widely applied to this task. However, deep learning-based medical coding lacks a unified view of the design of neural network architectures. This review proposes a unified framework to provide a general understanding of the building blocks of medical coding models and summarizes recent advanced models under the proposed framework. Our unified framework decomposes medical coding into four main components, i.e., encoder modules for text feature extraction, mechanisms for building deep encoder architectures, decoder modules for transforming hidden representations into medical codes, and the usage of auxiliary information. Finally, we introduce the benchmarks and real-world usage and discuss key research challenges and future directions.

Pretrained language models have been used in various natural language processing applications. In the mental health domain, domain-specific language models are pretrained and released, which facilitates the early detection of mental health conditions. Social posts, e.g., on Reddit, are usually long documents. However, there are no domain-specific pretrained models for long-sequence modeling in the mental health domain. This paper conducts domain-specific continued pretraining to capture the long context for mental health. Specifically, we train and release MentalXLNet and MentalLongformer based on XLNet and Longformer. We evaluate the mental health classification performance and the long-range ability of these two domain-specific pretrained models. Our models are released in HuggingFace.

Mental illnesses are one of the most prevalent public health problems worldwide, which negatively influence people's lives and society's health. With the increasing popularity of social media, there has been a growing research interest in the early detection of mental illness by analysing user-generated posts on social media. According to the correlation between emotions and mental illness, leveraging and fusing emotion information has developed into a valuable research topic. In this article, we provide a comprehensive survey of approaches to mental illness detection in social media that incorporate emotion fusion. We begin by reviewing different fusion strategies, along with their advantages and disadvantages. Subsequently, we discuss the major challenges faced by researchers working in this area, including issues surrounding the availability and quality of datasets, the performance of algorithms and interpretability. We additionally suggest some potential directions for future research.

Adverse drug events (ADEs) are an important aspect of drug safety. Various texts such as biomedical literature, drug reviews, and user posts on social media and medical forums contain a wealth of information about ADEs. Recent studies have applied word embedding and deep learning -based natural language processing to automate ADE detection from text. However, they did not explore incorporating explicit medical knowledge about drugs and adverse reactions or the corresponding feature learning. This paper adopts the heterogenous text graph which describes relationships between documents, words and concepts, augments it with medical knowledge from the Unified Medical Language System, and proposes a concept-aware attention mechanism which learns features differently for the different types of nodes in the graph. We further utilize contextualized embeddings from pretrained language models and convolutional graph neural networks for effective feature representation and relational learning. Experiments on four public datasets show that our model achieves performance competitive to the recent advances and the concept-aware attention consistently outperforms other attention mechanisms.

Multitask deep learning has been applied to patient outcome prediction from text, taking clinical notes as input and training deep neural networks with a joint loss function of multiple tasks. However, the joint training scheme of multitask learning suffers from inter-task interference, and diagnosis prediction among the multiple tasks has the generalizability issue due to rare diseases or unseen diagnoses. To solve these challenges, we propose a hypernetwork-based approach that generates task-conditioned parameters and coefficients of multitask prediction heads to learn task-specific prediction and balance the multitask learning. We also incorporate semantic task information to improves the generalizability of our task-conditioned multitask model. Experiments on early and discharge notes extracted from the real-world MIMIC database show our method can achieve better performance on multitask patient outcome prediction than strong baselines in most cases. Besides, our method can effectively handle the scenario with limited information and improve zero-shot prediction on unseen diagnosis categories.

Suicide is a critical issue in the modern society. Early detection and prevention of suicide attempt should be addressed to save people's life. Current suicidal ideation detection methods include clinical methods based on the interaction between social workers or experts and the targeted individuals, and machine learning techniques with feature engineering or deep learning for automatic detection based on online social contents. This is the first survey that comprehensively introduces and discusses the methods from these categories. Domain-specific applications of suicidal ideation detection are also reviewed according to their data sources, i.e., questionnaires, electronic health records, suicide notes, and online user content. To facilitate further research, several specific tasks and datasets are introduced. Finally, we summarize the limitations of current work and provide an outlook of further research directions.