Medical report generation automates radiology descriptions from images, easing the burden on physicians and minimizing errors. However, current methods lack structured outputs and physician interactivity for clear, clinically relevant reports. Our method introduces a prompt-guided approach to generate structured chest X-ray reports using a pre-trained large language model (LLM). First, we identify anatomical regions in chest X-rays to generate focused sentences that center on key visual elements, thereby establishing a structured report foundation with anatomy-based sentences. We also convert the detected anatomy into textual prompts conveying anatomical comprehension to the LLM. Additionally, the clinical context prompts guide the LLM to emphasize interactivity and clinical requirements. By integrating anatomy-focused sentences and anatomy/clinical prompts, the pre-trained LLM can generate structured chest X-ray reports tailored to prompted anatomical regions and clinical contexts. We evaluate using language generation and clinical effectiveness metrics, demonstrating strong performance.

Background: Single-cell RNA sequencing (scRNA-seq) yields valuable insights about gene expression and gives critical information about complex tissue cellular composition. In the analysis of single-cell RNA sequencing, the annotations of cell subtypes are often done manually, which is time-consuming and irreproducible. Garnett is a cell-type annotation software based the on elastic net method. Besides cell-type annotation, supervised machine learning methods can also be applied to predict other cell phenotypes from genomic data. Despite the popularity of such applications, there is no existing study to systematically investigate the performance of those supervised algorithms in various sizes of scRNA-seq data sets. Methods and Results: This study evaluates 13 popular supervised machine learning algorithms to classify cell phenotypes, using published real and simulated data sets with diverse cell sizes. The benchmark contained two parts. In the first part, we used real data sets to assess the popular supervised algorithms' computing speed and cell phenotype classification performance. The classification performances were evaluated using AUC statistics, F1-score, precision, recall, and false-positive rate. In the second part, we evaluated gene selection performance using published simulated data sets with a known list of real genes. Conclusion: The study outcomes showed that ElasticNet with interactions performed best in small and medium data sets. NB was another appropriate method for medium data sets. In large data sets, XGB works excellent. Ensemble algorithms were not significantly superior to individual machine learning methods. Adding interactions to ElasticNet can help, and the improvement was significant in small data sets.

Convolution is a central operation in Convolutional Neural Networks (CNNs), which applies a kernel or mask to overlapping regions shifted across the image. In this work we show that the underlying kernels are trained with highly correlated data, which leads to co-adaptation of model weights. To address this issue we propose what we call network deconvolution, a procedure that aims to remove pixel-wise and channel-wise correlations before the data is fed into each layer. We show that by removing this correlation we are able to achieve better convergence rates during model training with superior results without the use of batch normalization on the CIFAR-10, CIFAR-100, MNIST, Fashion-MNIST datasets, as well as against reference models from "model zoo" on the ImageNet standard benchmark.