Chronic kidney disease (CKD) is a major global health issue, affecting over 10% of the population and causing significant mortality. While kidney biopsy remains the gold standard for CKD diagnosis and treatment, the lack of comprehensive benchmarks for kidney pathology segmentation hinders progress in the field. To address this, we organized the Kidney Pathology Image Segmentation (KPIs) Challenge, introducing a dataset that incorporates preclinical rodent models of CKD with over 10,000 annotated glomeruli from 60+ Periodic Acid Schiff (PAS)-stained whole slide images. The challenge includes two tasks, patch-level segmentation and whole slide image segmentation and detection, evaluated using the Dice Similarity Coefficient (DSC) and F1-score. By encouraging innovative segmentation methods that adapt to diverse CKD models and tissue conditions, the KPIs Challenge aims to advance kidney pathology analysis, establish new benchmarks, and enable precise, large-scale quantification for disease research and diagnosis.

Training AI foundation models has emerged as a promising large-scale learning approach for addressing real-world healthcare challenges, including digital pathology. While many of these models have been developed for tasks like disease diagnosis and tissue quantification using extensive and diverse training datasets, their readiness for deployment on some arguably simplest tasks, such as nuclei segmentation within a single organ (e.g., the kidney), remains uncertain. This paper seeks to answer this key question, "How good are we?", by thoroughly evaluating the performance of recent cell foundation models on a curated multi-center, multi-disease, and multi-species external testing dataset. Additionally, we tackle a more challenging question, "How can we improve?", by developing and assessing human-in-the-loop data enrichment strategies aimed at enhancing model performance while minimizing the reliance on pixel-level human annotation. To address the first question, we curated a multicenter, multidisease, and multispecies dataset consisting of 2,542 kidney whole slide images (WSIs). Three state-of-the-art (SOTA) cell foundation models-Cellpose, StarDist, and CellViT-were selected for evaluation. To tackle the second question, we explored data enrichment algorithms by distilling predictions from the different foundation models with a human-in-the-loop framework, aiming to further enhance foundation model performance with minimal human efforts. Our experimental results showed that all three foundation models improved over their baselines with model fine-tuning with enriched data. Interestingly, the baseline model with the highest F1 score does not yield the best segmentation outcomes after fine-tuning. This study establishes a benchmark for the development and deployment of cell vision foundation models tailored for real-world data applications.

Archaeology has long faced fundamental issues of sampling and scalar representation. Traditionally, the local-to-regional-scale views of settlement patterns are produced through systematic pedestrian surveys. Recently, systematic manual survey of satellite and aerial imagery has enabled continuous distributional views of archaeological phenomena at interregional scales. However, such 'brute force' manual imagery survey methods are both time- and labor-intensive, as well as prone to inter-observer differences in sensitivity and specificity. The development of self-supervised learning methods offers a scalable learning scheme for locating archaeological features using unlabeled satellite and historical aerial images. However, archaeological features are generally only visible in a very small proportion relative to the landscape, while the modern contrastive-supervised learning approach typically yields an inferior performance on highly imbalanced datasets. In this work, we propose a framework to address this long-tail problem. As opposed to the existing contrastive learning approaches that treat the labelled and unlabeled data separately, our proposed method reforms the learning paradigm under a semi-supervised setting in order to utilize the precious annotated data (<7% in our setting). Specifically, the highly unbalanced nature of the data is employed as the prior knowledge in order to form pseudo negative pairs by ranking the similarities between unannotated image patches and annotated anchor images. In this study, we used 95,358 unlabeled images and 5,830 labelled images in order to solve the issues associated with detecting ancient buildings from a long-tailed satellite image dataset. From the results, our semi-supervised contrastive learning model achieved a promising testing balanced accuracy of 79.0%, which is a 3.8% improvement as compared to other state-of-the-art approaches.