Self-supervised learning (SSL) has emerged as a promising technique for medical image analysis due to its ability to learn without annotations. However, despite the promising potential, conventional SSL methods encounter limitations, including challenges in achieving semantic alignment and capturing subtle details. This leads to suboptimal representations, which fail to accurately capture the underlying anatomical structures and pathological details. In response to these constraints, we introduce a novel SSL framework OPTiML, employing optimal transport (OT), to capture the dense semantic invariance and fine-grained details, thereby enhancing the overall effectiveness of SSL in medical image representation learning. The core idea is to integrate OT with a cross-viewpoint semantics infusion module (CV-SIM), which effectively captures complex, fine-grained details inherent in medical images across different viewpoints. In addition to the CV-SIM module, OPTiML imposes the variance and covariance regularizations within OT framework to force the model focus on clinically relevant information while discarding less informative features. Through these, the proposed framework demonstrates its capacity to learn semantically rich representations that can be applied to various medical imaging tasks. To validate its effectiveness, we conduct experimental studies on three publicly available datasets from chest X-ray modality. Our empirical results reveal OPTiML's superiority over state-of-the-art methods across all evaluated tasks.

Self-supervised learning (SSL) is potentially useful in reducing the need for manual annotation and making deep learning models accessible for medical image analysis tasks. By leveraging the representations learned from unlabeled data, self-supervised models perform well on tasks that require little to no fine-tuning. However, for medical images, like chest X-rays, which are characterized by complex anatomical structures and diverse clinical conditions, there arises a need for representation learning techniques that can encode fine-grained details while preserving the broader contextual information. In this context, we introduce MLVICX (Multi-Level Variance-Covariance Exploration for Chest X-ray Self-Supervised Representation Learning), an approach to capture rich representations in the form of embeddings from chest X-ray images. Central to our approach is a novel multi-level variance and covariance exploration strategy that empowers the model to detect diagnostically meaningful patterns while reducing redundancy effectively. By enhancing the variance and covariance of the learned embeddings, MLVICX promotes the retention of critical medical insights by adapting both global and local contextual details. We demonstrate the performance of MLVICX in advancing self-supervised chest X-ray representation learning through comprehensive experiments. The performance enhancements we observe across various downstream tasks highlight the significance of the proposed approach in enhancing the utility of chest X-ray embeddings for precision medical diagnosis and comprehensive image analysis. For pertaining, we used the NIH-Chest X-ray dataset, while for downstream tasks, we utilized NIH-Chest X-ray, Vinbig-CXR, RSNA pneumonia, and SIIM-ACR Pneumothorax datasets. Overall, we observe more than 3% performance gains over SOTA SSL approaches in various downstream tasks.

Deep learning has demonstrated remarkable achievements in medical image segmentation. However, prevailing deep learning models struggle with poor generalization due to (i) intra-class variations, where the same class appears differently in different samples, and (ii) inter-class independence, resulting in difficulties capturing intricate relationships between distinct objects, leading to higher false negative cases. This paper presents a novel approach that synergies spatial and spectral representations to enhance domain-generalized medical image segmentation. We introduce the innovative Spectral Correlation Coefficient objective to improve the model's capacity to capture middle-order features and contextual long-range dependencies. This objective complements traditional spatial objectives by incorporating valuable spectral information. Extensive experiments reveal that optimizing this objective with existing architectures like UNet and TransUNet significantly enhances generalization, interpretability, and noise robustness, producing more confident predictions. For instance, in cardiac segmentation, we observe a 0.81 pp and 1.63 pp (pp = percentage point) improvement in DSC over UNet and TransUNet, respectively. Our interpretability study demonstrates that, in most tasks, objectives optimized with UNet outperform even TransUNet by introducing global contextual information alongside local details. These findings underscore the versatility and effectiveness of our proposed method across diverse imaging modalities and medical domains.

Knowledge distillation(KD) has demonstrated remarkable success across various domains, but its application to medical imaging tasks, such as kidney and liver tumor segmentation, has encountered challenges. Many existing KD methods are not specifically tailored for these tasks. Moreover, prevalent KD methods often lack a careful consideration of what and from where to distill knowledge from the teacher to the student. This oversight may lead to issues like the accumulation of training bias within shallower student layers, potentially compromising the effectiveness of KD. To address these challenges, we propose Hierarchical Layer-selective Feedback Distillation (HLFD). HLFD strategically distills knowledge from a combination of middle layers to earlier layers and transfers final layer knowledge to intermediate layers at both the feature and pixel levels. This design allows the model to learn higher-quality representations from earlier layers, resulting in a robust and compact student model. Extensive quantitative evaluations reveal that HLFD outperforms existing methods by a significant margin. For example, in the kidney segmentation task, HLFD surpasses the student model (without KD) by over 10pp, significantly improving its focus on tumor-specific features. From a qualitative standpoint, the student model trained using HLFD excels at suppressing irrelevant information and can focus sharply on tumor-specific details, which opens a new pathway for more efficient and accurate diagnostic tools.