Federated learning (FL) has gained widespread attention for its privacy-preserving and collaborative learning capabilities. Due to significant statistical heterogeneity, traditional FL struggles to generalize a shared model across diverse data domains. Personalized federated learning addresses this issue by dividing the model into a globally shared part and a locally private part, with the local model correcting representation biases introduced by the global model. Nevertheless, locally converged parameters more accurately capture domain-specific knowledge, and current methods overlook the potential benefits of these parameters. To address these limitations, we propose PM-MoE architecture. This architecture integrates a mixture of personalized modules and an energy-based personalized modules denoising, enabling each client to select beneficial personalized parameters from other clients. We applied the PM-MoE architecture to nine recent model-split-based personalized federated learning algorithms, achieving performance improvements with minimal additional training. Extensive experiments on six widely adopted datasets and two heterogeneity settings validate the effectiveness of our approach. The source code is available at \url{https://github.com/dannis97500/PM-MOE}.

Multi-task model merging offers an efficient solution for integrating knowledge from multiple fine-tuned models, mitigating the significant computational and storage demands associated with multi-task training. Despite the promising performance of TA, conflicts can arise among the task vectors, particularly when different tasks require distinct model adaptations. In this paper, we formally define this issue as knowledge conflicts, characterized by the performance degradation of one task after merging with a model fine-tuned for another task. Restricting parameter merging within this trust region, TATR can effectively alleviate knowledge conflicts. Moreover, TATR serves as both an independent approach and a plug-and-play module compatible with a wide range of TAbased methods. Extensive empirical evaluations on eight distinct datasets robustly demonstrate that TATR improves the multi-task performance of several TA-based model merging methods by an observable margin. The growing adoption of large foundation models is accompanied by significant practical challenges in terms of computational and storage demands (Kaplan et al., 2020). To address these challenges, multi-task model merging (Matena & Raffel, 2022) has emerged as a promising solution. Here task vectors are the difference in model parameters between the pre-trained foundation model and its fine-tuned version on a specific task. This approach builds a high-performance multi-task model by simple arithmetic operations in the model parameter space, thereby reducing computational overheads associated with fine-tuning on multiple tasks. Despite their successes, task arithmetic and its variants (Yadav et al., 2023; Wang et al., 2024; Yang et al., 2024b;a) still suffer from conflicts between task vectors.

Protein language models have shown remarkable success in learning biological information from protein sequences. However, most existing models are limited by either autoencoding or autoregressive pre-training objectives, which makes them struggle to handle protein understanding and generation tasks concurrently. We propose a unified protein language model, xTrimoPGLM, to address these two types of tasks simultaneously through an innovative pre-training framework. Our key technical contribution is an exploration of the compatibility and the potential for joint optimization of the two types of objectives, which has led to a strategy for training xTrimoPGLM at an unprecedented scale of 100 billion parameters and 1 trillion training tokens. Our extensive experiments reveal that 1) xTrimoPGLM significantly outperforms other advanced baselines in 18 protein understanding benchmarks across four categories. The model also facilitates an atomic-resolution view of protein structures, leading to an advanced 3D structural prediction model that surpasses existing language model-based tools. 2) xTrimoPGLM not only can generate de novo protein sequences following the principles of natural ones, but also can perform programmable generation after supervised fine-tuning (SFT) on curated sequences. These results highlight the substantial capability and versatility of xTrimoPGLM in understanding and generating protein sequences, contributing to the evolving landscape of foundation models in protein science.

The exemplar-free class incremental learning requires classification models to learn new class knowledge incrementally without retaining any old samples. Recently, the framework based on parallel one-class classifiers (POC), which trains a one-class classifier (OCC) independently for each category, has attracted extensive attention, since it can naturally avoid catastrophic forgetting. POC, however, suffers from weak discriminability and comparability due to its independent training strategy for different OOCs. To meet this challenge, we propose a new framework, named Discriminative and Comparable One-class classifiers for Incremental Learning (DisCOIL). DisCOIL follows the basic principle of POC, but it adopts variational auto-encoders (VAE) instead of other well-established one-class classifiers (e.g. deep SVDD), because a trained VAE can not only identify the probability of an input sample belonging to a class but also generate pseudo samples of the class to assist in learning new tasks. With this advantage, DisCOIL trains a new-class VAE in contrast with the old-class VAEs, which forces the new-class VAE to reconstruct better for new-class samples but worse for the old-class pseudo samples, thus enhancing the comparability. Furthermore, DisCOIL introduces a hinge reconstruction loss to ensure the discriminability. We evaluate our method extensively on MNIST, CIFAR10, and Tiny-ImageNet. The experimental results show that DisCOIL achieves state-of-the-art performance.