Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features using a pre-trained feature extractor and then aggregates these features through MIL. This segmented training approach leads to insufficient collaborative optimization between the feature extraction network and the MIL network, preventing end-to-end joint optimization and thereby limiting the overall performance of the model. Additionally, conventional methods typically extract features from all patches of fixed size, ignoring the multi-scale observation characteristics of pathologists. This not only results in significant computational resource waste when tumor regions represent a minimal proportion (as in the Camelyon16 dataset) but may also lead the model to suboptimal solutions. To address these limitations, this paper proposes an end-to-end multi-scale WSI classification framework that integrates multi-scale feature extraction with multiple instance learning. Specifically, our approach includes: (1) a semantic feature filtering module to reduce interference from non-lesion areas; (2) a multi-scale feature extraction module to capture pathological information at different levels; and (3) a multi-scale fusion MIL module for global modeling and feature integration. Through an end-to-end training strategy, we simultaneously optimize both the feature extractor and MIL network, ensuring maximum compatibility between them. Experiments were conducted on three cross-center datasets (DigestPath2019, BCNB, and UBC-OCEAN). Results demonstrate that our proposed method outperforms existing state-of-the-art approaches in terms of both accuracy (ACC) and AUC metrics.

Color constancy estimates illuminant chromaticity to correct color-biased images. Recently, Deep Neural Network-driven Color Constancy (DNNCC) models have made substantial advancements. Nevertheless, the potential risks in DNNCC due to the vulnerability of deep neural networks have not yet been explored. In this paper, we conduct the first investigation into the impact of a key factor in color constancy-brightness-on DNNCC from a robustness perspective. Our evaluation reveals that several mainstream DNNCC models exhibit high sensitivity to brightness despite their focus on chromaticity estimation. This sheds light on a potential limitation of existing DNNCC models: their sensitivity to brightness may hinder performance given the widespread brightness variations in real-world datasets. From the insights of our analysis, we propose a simple yet effective brightness robustness enhancement strategy for DNNCC models, termed BRE. The core of BRE is built upon the adaptive step-size adversarial brightness augmentation technique, which identifies high-risk brightness variation and generates augmented images via explicit brightness adjustment. Subsequently, BRE develops a brightness-robustness-aware model optimization strategy that integrates adversarial brightness training and brightness contrastive loss, significantly bolstering the brightness robustness of DNNCC models. BRE is hyperparameter-free and can be integrated into existing DNNCC models, without incurring additional overhead during the testing phase. Experiments on two public color constancy datasets-ColorChecker and Cube+-demonstrate that the proposed BRE consistently enhances the illuminant estimation performance of existing DNNCC models, reducing the estimation error by an average of 5.04% across six mainstream DNNCC models, underscoring the critical role of enhancing brightness robustness in these models.