--Skeleton-based T emporal Action Segmentation (ST AS) aims to segment and recognize various actions from long, untrimmed sequences of human skeletal movements. Current ST AS methods typically employ spatio-temporal modeling to establish dependencies among joints as well as frames, and utilize one-hot encoding with cross-entropy loss for frame-wise classification supervision. However, these methods overlook the intrinsic correlations among joints and actions within skeletal features, leading to a limited understanding of human movements. T o address this, we propose a T ext-Derived Relational Graph-Enhanced Network (TRG-Net) that leverages prior graphs generated by Large Language Models (LLM) to enhance both modeling and supervision. For modeling, the Dynamic Spatio-T emporal Fusion Modeling (DSFM) method incorporates T ext-Derived Joint Graphs (TJG) with channel-and frame-level dynamic adaptation to effectively model spatial relations, while integrating spatio-temporal core features during temporal modeling. For supervision, the Absolute-Relative Inter-Class Supervision (ARIS) method employs contrastive learning between action features and text embeddings to regularize the absolute class distributions, and utilizes T ext-Derived Action Graphs (T AG) to capture the relative inter-class relationships among action features. Additionally, we propose a Spatial-A ware Enhancement Processing (SAEP) method, which incorporates random joint occlusion and axial rotation to enhance spatial generalization. Performance evaluations on four public datasets demonstrate that TRG-Net achieves state-of-the-art results. EMPORAL Action Segmentation (T AS), an advanced task in video understanding, aims to segment and recognize each action within long, untrimmed video sequences of human activities [1]. Similar to how semantic segmentation predicts labels for each pixel in an image, T AS predicts action labels for each frame in a video. As a significant task in computer vision, T AS finds applications in various domains such as medical rehabilitation, [2], industrial monitoring [3], and activity analysis [4]. Haoyu Ji, Bowen Chen, Weihong Ren, Wenze Huang, Zhihao Y ang, Zhiyong Wang, and Honghai Liu are with the State Key Laboratory of Robotics and Systems, Harbin Institute of Technology Shenzhen, Shenzhen 518055, China (e-mail: jihaoyu1224@gmail.com, The code is available at https://github.com/HaoyuJi/TRG-Net. The text embeddings and relational graphs generated by large language models can serve as priors for enhancing modeling and supervision of action segmentation. Specifically, the text-derived joint graph effectively captures spatial correlations, while the text-derived action graph and action embeddings supervise the relationships and distributions of action classes. Existing T AS methods can be broadly categorized into two types based on input modality: Video-based T AS (VT AS) and Skeleton-based T AS (ST AS) [5]-[7].

Tasks such as chronic disease Large language models (LLMs) have emerged management, multi-visit care planning, and patient history as promising tools for assisting in medical tasks, synthesis require clinicians to understand complex relationships yet processing Electronic Health Records (EHRs) between different record entries and how past events presents unique challenges due to their longitudinal influence current and future clinical decisions (Wornow nature. While LLMs' capabilities to perform et al., 2024). The cognitive demands of processing such medical tasks continue to improve, their ability lengthy documentation are significant. While biomedical to reason over temporal dependencies across LLMs have shown promising results on well-structured multiple patient visits and time frames remains tasks like answering USMLE questions and medical knowledge unexplored. We introduce TIMER (Temporal retrieval (Singhal et al., 2023; Lu et al., 2024; Lucas Instruction Modeling and Evaluation for Longitudinal et al., 2024), recent evaluations reveal their significant limitations Clinical Records), a framework that incorporate in processing longitudinal patient information and in instruction-response pairs grounding to making clinical decisions over time (Hager et al., 2024; Bedi different parts of a patient's record as a critical et al., 2024). The gap between isolated question-answering dimension in both instruction evaluation and tuning performance and temporal reasoning ability impacts the for longitudinal clinical records. We develop practical utility of LLMs in healthcare. While there is some TIMER-Bench, the first time-aware benchmark prior work that has explored temporal understanding abilities that evaluates temporal reasoning capabilities over of general LLMs (Wang & Zhao, 2024; Fatemi et al., longitudinal EHRs, as well as TIMER-Instruct, 2024; Herel et al., 2024), how these capabilities scale to an instruction-tuning methodology for LLMs to longer contexts remains understudied, particularly in healthcare learn reasoning over time. We demonstrate that where longitudinal reasoning is important.

Solving complex reasoning tasks may involve visual understanding, domain knowledge retrieval, numerical calculation, and multi-step reasoning. Existing methods augment large language models (LLMs) with external tools but are restricted to specialized domains, limited tool types, or require additional training data. In this paper, we introduce OctoTools, a training-free, user-friendly, and easily extensible open-source agentic framework designed to tackle complex reasoning across diverse domains. OctoTools introduces standardized tool cards to encapsulate tool functionality, a planner for both high-level and low-level planning, and an executor to carry out tool usage. We validate OctoTools' generality across 16 diverse tasks (including MathVista, MMLU-Pro, MedQA, and GAIA-Text), achieving substantial average accuracy gains of 9.3% over GPT-4o. Furthermore, OctoTools outperforms AutoGen, GPT-Functions and LangChain by up to 10.6% when given the same set of tools. Through comprehensive analysis and ablations, OctoTools demonstrates advantages in task planning, effective tool usage, and multi-step problem solving.

The lack of data transparency in Large Language Models (LLMs) has highlighted the importance of Membership Inference Attack (MIA), which differentiates trained (member) and untrained (non-member) data. Though it shows success in previous studies, recent research reported a near-random performance in different settings, highlighting a significant performance inconsistency. We assume that a single setting doesn't represent the distribution of the vast corpora, causing members and non-members with different distributions to be sampled and causing inconsistency. In this study, instead of a single setting, we statistically revisit MIA methods from various settings with thousands of experiments for each MIA method, along with study in text feature, embedding, threshold decision, and decoding dynamics of members and non-members. We found that (1) MIA performance improves with model size and varies with domains, while most methods do not statistically outperform baselines, (2) Though MIA performance is generally low, a notable amount of differentiable member and non-member outliers exists and vary across MIA methods, (3) Deciding a threshold to separate members and non-members is an overlooked challenge, (4) Text dissimilarity and long text benefit MIA performance, (5) Differentiable or not is reflected in the LLM embedding, (6) Member and non-members show different decoding dynamics.

The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via self-supervised learning (SSL). However, translating these advancements to address complex clinical challenges at the patient and slide level remains constrained by limited clinical data in disease-specific cohorts, especially for rare clinical conditions. We propose TITAN, a multimodal whole slide foundation model pretrained using 335,645 WSIs via visual self-supervised learning and vision-language alignment with corresponding pathology reports and 423,122 synthetic captions generated from a multimodal generative AI copilot for pathology. Without any finetuning or requiring clinical labels, TITAN can extract general-purpose slide representations and generate pathology reports that generalize to resource-limited clinical scenarios such as rare disease retrieval and cancer prognosis. We evaluate TITAN on diverse clinical tasks and find that TITAN outperforms both ROI and slide foundation models across machine learning settings such as linear probing, few-shot and zero-shot classification, rare cancer retrieval and cross-modal retrieval, and pathology report generation.

This paper introduces LLM-jp, a cross-organizational project for the research and development of Japanese large language models (LLMs). LLM-jp aims to develop open-source and strong Japanese LLMs, and as of this writing, more than 1,500 participants from academia and industry are working together for this purpose. This paper presents the background of the establishment of LLM-jp, summaries of its activities, and technical reports on the LLMs developed by LLM-jp.

Large Language Models (LLMs), trained on massive corpora with billions of parameters, show unprecedented performance in various fields. Though surprised by their excellent performances, researchers also noticed some special behaviors of those LLMs. One of those behaviors is memorization, in which LLMs can generate the same content used to train them. Though previous research has discussed memorization, the memorization of LLMs still lacks explanation, especially the cause of memorization and the dynamics of generating them. In this research, we comprehensively discussed memorization from various perspectives and extended the discussion scope to not only just the memorized content but also less and unmemorized content. Through various studies, we found that: (1) Through experiments, we revealed the relation of memorization between model size, continuation size, and context size. Further, we showed how unmemorized sentences transition to memorized sentences. (2) Through embedding analysis, we showed the distribution and decoding dynamics across model size in embedding space for sentences with different memorization scores. The n-gram statistics analysis presents d (3) An analysis over n-gram and entropy decoding dynamics discovered a boundary effect when the model starts to generate memorized sentences or unmemorized sentences. (4)We trained a Transformer model to predict the memorization of different models, showing that it is possible to predict memorizations by context.

Benefiting from the rapid development of 2D diffusion models, 3D content creation has made significant progress recently. One promising solution involves the fine-tuning of pre-trained 2D diffusion models to harness their capacity for producing multi-view images, which are then lifted into accurate 3D models via methods like fast-NeRFs or large reconstruction models. However, as inconsistency still exists and limited generated resolution, the generation results of such methods still lack intricate textures and complex geometries. To solve this problem, we propose Magic-Boost, a multi-view conditioned diffusion model that significantly refines coarse generative results through a brief period of SDS optimization ($\sim15$min). Compared to the previous text or single image based diffusion models, Magic-Boost exhibits a robust capability to generate images with high consistency from pseudo synthesized multi-view images. It provides precise SDS guidance that well aligns with the identity of the input images, enriching the local detail in both geometry and texture of the initial generative results. Extensive experiments show Magic-Boost greatly enhances the coarse inputs and generates high-quality 3D assets with rich geometric and textural details. (Project Page: https://magic-research.github.io/magic-boost/)

The field of computational pathology has witnessed remarkable progress in the development of both task-specific predictive models and task-agnostic self-supervised vision encoders. However, despite the explosive growth of generative artificial intelligence (AI), there has been limited study on building general purpose, multimodal AI assistants tailored to pathology. Here we present PathChat, a vision-language generalist AI assistant for human pathology using an in-house developed foundational vision encoder pretrained on 100 million histology images from over 100,000 patient cases and 1.18 million pathology image-caption pairs. The vision encoder is then combined with a pretrained large language model and the whole system is finetuned on over 250,000 diverse disease agnostic visual language instructions. We compare PathChat against several multimodal vision language AI assistants as well as GPT4V, which powers the commercially available multimodal general purpose AI assistant ChatGPT-4. When relevant clinical context is provided with the histology image, PathChat achieved a diagnostic accuracy of 87% on multiple-choice questions based on publicly available cases of diverse tissue origins and disease models. Additionally, using open-ended questions and human expert evaluation, we found that overall PathChat produced more accurate and pathologist-preferable responses to diverse queries related to pathology. As an interactive and general vision language AI assistant that can flexibly handle both visual and natural language inputs, PathChat can potentially find impactful applications in pathology education, research, and human-in-the-loop clinical decision making.

The accelerated adoption of digital pathology and advances in deep learning have enabled the development of powerful models for various pathology tasks across a diverse array of diseases and patient cohorts. However, model training is often difficult due to label scarcity in the medical domain and the model's usage is limited by the specific task and disease for which it is trained. Additionally, most models in histopathology leverage only image data, a stark contrast to how humans teach each other and reason about histopathologic entities. We introduce CONtrastive learning from Captions for Histopathology (CONCH), a visual-language foundation model developed using diverse sources of histopathology images, biomedical text, and notably over 1.17 million image-caption pairs via task-agnostic pretraining. Evaluated on a suite of 13 diverse benchmarks, CONCH can be transferred to a wide range of downstream tasks involving either or both histopathology images and text, achieving state-of-the-art performance on histology image classification, segmentation, captioning, text-to-image and image-to-text retrieval. CONCH represents a substantial leap over concurrent visual-language pretrained systems for histopathology, with the potential to directly facilitate a wide array of machine learning-based workflows requiring minimal or no further supervised fine-tuning.