Discovering the genotype-phenotype relationship is crucial for genetic engineering, which will facilitate advances in fields such as crop breeding, conservation biology, and personalized medicine. Current research usually focuses on single species and small datasets due to limitations in phenotypic data collection, especially for traits that require visual assessments or physical measurements. Deciphering complex and composite phenotypes, such as morphology, from genetic data at scale remains an open question. To break through traditional generic models that rely on simplified assumptions, this paper introduces G2PDiffusion, the first-of-its-kind diffusion model designed for genotype-to-phenotype generation across multiple species. Specifically, we use images to represent morphological phenotypes across species and redefine phenotype prediction as conditional image generation. To this end, this paper introduces an environment-enhanced DNA sequence conditioner and trains a stable diffusion model with a novel alignment method to improve genotype-to-phenotype consistency. Extensive experiments demonstrate that our approach enhances phenotype prediction accuracy across species, capturing subtle genetic variations that contribute to observable traits.

Human pose plays a crucial role in the digital age. While recent works have achieved impressive progress in understanding and generating human poses, they often support only a single modality of control signals and operate in isolation, limiting their application in real-world scenarios. This paper presents UniPose, a framework employing Large Language Models (LLMs) to comprehend, generate, and edit human poses across various modalities, including images, text, and 3D SMPL poses. Specifically, we apply a pose tokenizer to convert 3D poses into discrete pose tokens, enabling seamless integration into the LLM within a unified vocabulary. To further enhance the fine-grained pose perception capabilities, we facilitate UniPose with a mixture of visual encoders, among them a pose-specific visual encoder. Benefiting from a unified learning strategy, UniPose effectively transfers knowledge across different pose-relevant tasks, adapts to unseen tasks, and exhibits extended capabilities. This work serves as the first attempt at building a general-purpose framework for pose comprehension, generation, and editing. Extensive experiments highlight UniPose's competitive and even superior performance across various pose-relevant tasks.

Traditional semi-supervised learning (SSL) assumes that the feature distributions of labeled and unlabeled data are consistent which rarely holds in realistic scenarios. In this paper, we propose a novel SSL setting, where unlabeled samples are drawn from a mixed distribution that deviates from the feature distribution of labeled samples. Under this setting, previous SSL methods tend to predict wrong pseudo-labels with the model fitted on labeled data, resulting in noise accumulation. To tackle this issue, we propose Self-Supervised Feature Adaptation (SSFA), a generic framework for improving SSL performance when labeled and unlabeled data come from different distributions. SSFA decouples the prediction of pseudo-labels from the current model to improve the quality of pseudo-labels. Particularly, SSFA incorporates a self-supervised task into the SSL framework and uses it to adapt the feature extractor of the model to the unlabeled data. In this way, the extracted features better fit the distribution of unlabeled data, thereby generating high-quality pseudo-labels. Extensive experiments show that our proposed SSFA is applicable to various pseudo-label-based SSL learners and significantly improves performance in labeled, unlabeled, and even unseen distributions.

This paper presents a selective review of statistical computation methods for massive data analysis. A huge amount of statistical methods for massive data computation have been rapidly developed in the past decades. In this work, we focus on three categories of statistical computation methods: (1) distributed computing, (2) subsampling methods, and (3) minibatch gradient techniques. The first class of literature is about distributed computing and focuses on the situation, where the dataset size is too huge to be comfortably handled by one single computer. In this case, a distributed computation system with multiple computers has to be utilized. The second class of literature is about subsampling methods and concerns about the situation, where the sample size of dataset is small enough to be placed on one single computer but too large to be easily processed by its memory as a whole. The last class of literature studies those minibatch gradient related optimization techniques, which have been extensively used for optimizing various deep learning models.

Few-shot learning (FSL) aims to learn novel tasks with very few labeled samples by leveraging experience from \emph{related} training tasks. In this paper, we try to understand FSL by delving into two key questions: (1) How to quantify the relationship between \emph{training} and \emph{novel} tasks? (2) How does the relationship affect the \emph{adaptation difficulty} on novel tasks for different models? To answer the two questions, we introduce Task Attribute Distance (TAD) built upon attributes as a metric to quantify the task relatedness. Unlike many existing metrics, TAD is model-agnostic, making it applicable to different FSL models. Then, we utilize TAD metric to establish a theoretical connection between task relatedness and task adaptation difficulty. By deriving the generalization error bound on a novel task, we discover how TAD measures the adaptation difficulty on novel tasks for FSL models. To validate our TAD metric and theoretical findings, we conduct experiments on three benchmarks. Our experimental results confirm that TAD metric effectively quantifies the task relatedness and reflects the adaptation difficulty on novel tasks for various FSL methods, even if some of them do not learn attributes explicitly or human-annotated attributes are not available. Finally, we present two applications of the proposed TAD metric: data augmentation and test-time intervention, which further verify its effectiveness and general applicability. The source code is available at https://github.com/hu-my/TaskAttributeDistance.

Visual relationship detection aims to describe the interactions between pairs of objects. Different from individual object learning tasks, the number of possible relationships are much larger, which makes it hard to explore only based on the visual appearance of objects. In addition, due to the limited human effort, the annotations for visual relationships are usually incomplete which increases the difficulty of model training and evaluation. In this paper, we propose a novel framework, called Deep Structural Ranking, for visual relationship detection. To complement the representation ability of visual appearance, we integrate multiple cues for predicting the relationships contained in an input image. Moreover, we design a new ranking objective function by enforcing the annotated relationships to have higher relevance scores. Unlike previous works, our proposed method can both facilitate the co-occurrence of relationships and mitigate the incompleteness problem. Experimental results show that our proposed method outperforms the state-of-the-art on the two widely used datasets. We also demonstrate its superiority in detecting zero-shot relationships.

In this paper, we propose a generalized Unsupervised Manifold Alignment (GUMA) method to build the connections between different but correlated datasets without any known correspondences. Based on the assumption that datasets of the same theme usually have similar manifold structures, GUMA is formulated into an explicit integer optimization problem considering the structure matching and preserving criteria, as well as the feature comparability of the corresponding points in the mutual embedding space. The main benefits of this model include: (1) simultaneous discovery and alignment of manifold structures; (2) fully unsupervised matching without any pre-specified correspondences; (3) efficient iterative alignment without computations in all permutation cases. Experimental results on dataset matching and real-world applications demonstrate the effectiveness and the practicability of our manifold alignment method.