Purpose: To develop and validate a novel image reconstruction technique using implicit neural representations (INR) for multi-view thick-slice acquisitions while reducing the scan time but maintaining high signal-to-noise ratio (SNR). Methods: We propose Rotating-view super-resolution (ROVER)-MRI, an unsupervised neural network-based algorithm designed to reconstruct MRI data from multi-view thick slices, effectively reducing scan time by 2-fold while maintaining fine anatomical details. We compare our method to both bicubic interpolation and the current state-of-the-art regularized least-squares super-resolution reconstruction (LS-SRR) technique. Validation is performed using ground-truth ex-vivo monkey brain data, and we demonstrate superior reconstruction quality across several in-vivo human datasets. Notably, we achieve the reconstruction of a whole human brain in-vivo T2-weighted image with an unprecedented 180{\mu}m isotropic spatial resolution, accomplished in just 17 minutes of scan time on a 7T MRI scanner. Results: ROVER-MRI outperformed LS-SRR method in terms of reconstruction quality with 22.4% lower relative error (RE) and 7.5% lower full-width half maximum (FWHM) indicating better preservation of fine structural details in nearly half the scan time. Conclusion: ROVER-MRI offers an efficient and robust approach for mesoscale MR imaging, enabling rapid, high-resolution whole-brain scans. Its versatility holds great promise for research applications requiring anatomical details and time-efficient imaging.

Typical quantitative MRI (qMRI) methods estimate parameter maps after image reconstructing, which is prone to biases and error propagation. We propose a Nonlinear Conjugate Gradient (NLCG) optimizer for model-based T2/T1 estimation, which incorporates U-Net regularization trained in a scan-specific manner. This end-to-end method directly estimates qMRI maps from undersampled k-space data using mono-exponential signal modeling with zero-shot scan-specific neural network regularization to enable high fidelity T1 and T2 mapping. T2 and T1 mapping results demonstrate the ability of the proposed NLCG-Net to improve estimation quality compared to subspace reconstruction at high accelerations.

Diffusion MRI is commonly performed using echo-planar imaging (EPI) due to its rapid acquisition time. However, the resolution of diffusion-weighted images is often limited by magnetic field inhomogeneity-related artifacts and blurring induced by T2- and T2*-relaxation effects. To address these limitations, multi-shot EPI (msEPI) combined with parallel imaging techniques is frequently employed. Nevertheless, reconstructing msEPI can be challenging due to phase variation between multiple shots. In this study, we introduce a novel msEPI reconstruction approach called zero-MIRID (zero-shot self-supervised learning of Multi-shot Image Reconstruction for Improved Diffusion MRI). This method jointly reconstructs msEPI data by incorporating deep learning-based image regularization techniques. The network incorporates CNN denoisers in both k- and image-spaces, while leveraging virtual coils to enhance image reconstruction conditioning. By employing a self-supervised learning technique and dividing sampled data into three groups, the proposed approach achieves superior results compared to the state-of-the-art parallel imaging method, as demonstrated in an in-vivo experiment.

Dropout is conventionally used during the training phase as regularization method and for quantifying uncertainty in deep learning. We propose to use dropout during training as well as inference steps, and average multiple predictions to improve the accuracy, while reducing and quantifying the uncertainty. The results are evaluated for fractional anisotropy (FA) and mean diffusivity (MD) maps which are obtained from only 3 direction scans. With our method, accuracy can be improved significantly compared to network outputs without dropout, especially when the training dataset is small. Moreover, confidence maps are generated which may aid in diagnosis of unseen pathology or artifacts.

Sparse Bayesian learning (SBL) is a powerful framework for tackling the sparse coding problem while also providing uncertainty quantification. However, the most popular inference algorithms for SBL become too expensive for high-dimensional problems due to the need to maintain a large covariance matrix. To resolve this issue, we introduce a new SBL inference algorithm that avoids explicit computation of the covariance matrix, thereby saving significant time and space. Instead of performing costly matrix inversions, our covariance-free method solves multiple linear systems to obtain provably unbiased estimates of the posterior statistics needed by SBL. These systems can be solved in parallel, enabling further acceleration of the algorithm via graphics processing units. In practice, our method can be up to thousands of times faster than existing baselines, reducing hours of computation time to seconds. We showcase how our new algorithm enables SBL to tractably tackle high-dimensional signal recovery problems, such as deconvolution of calcium imaging data and multi-contrast reconstruction of magnetic resonance images. Finally, we open-source a toolbox containing all of our implementations to drive future research in SBL.

We propose Nonlinear Dipole Inversion (NDI) for high - quality Quantitative Susceptibility Mapping (QSM) without regularization tuning, while matching the image quality of state - of - the - art reconstruction techniques. In addition to avoiding over - smoothing that these techniques often suffer from, we also ob viate the need for parameter selection. NDI is flexible enough to allow for reconstruction from an arbitrary number of head orientations, and outperforms COSMOS even when using as few as 1 - direction data . This is made possible by a nonlinear forward - model that uses the magnitude as an effective prior, for which we derived a simple gradient descent update rule . We synergistically combine this physics - model with a Variational Network (VN) to leverage the power of d eep l earning in the VaNDI algorithm. This technique adopts the simple gradient descent rule from NDI and learns the network parameters during training, hence requires no additional parameter tuning. Further, we evaluate NDI at 7T using highly accelerated Wave - CAIPI acquisition s at 0.5 mm isotropic resolutio n and demonstrate high - quality QSM from as f e w as 2 - direction data .

Purpose: To introduce a combined machine learning (ML) and physics-based image reconstruction framework that enables navigator-free, highly accelerated multishot echo planar imaging (msEPI), and demonstrate its application in high-resolution structural imaging. Methods: Singleshot EPI is an efficient encoding technique, but does not lend itself well to high-resolution imaging due to severe distortion artifacts and blurring. While msEPI can mitigate these artifacts, high-quality msEPI has been elusive because of phase mismatch arising from shot-to-shot physiological variations which disrupt the combination of the multiple-shot data into a single image. We employ Deep Learning to obtain an interim magnitude-valued image with minimal artifacts, which permits estimation of image phase variations due to shot-to-shot physiological changes. These variations are then included in a Joint Virtual Coil Sensitivity Encoding (JVC-SENSE) reconstruction to utilize data from all shots and improve upon the ML solution. Results: Our combined ML + physics approach enabled R=8-fold acceleration from 2 EPI-shots while providing 1.8-fold error reduction compared to the MUSSELS, a state-of-the-art reconstruction technique, which is also used as an input to our ML network. Using 3 shots allowed us to push the acceleration to R=10-fold, where we obtained a 1.7-fold error reduction over MUSSELS. Conclusion: Combination of ML and JVC-SENSE enabled navigator-free msEPI at higher accelerations than previously possible while using fewer shots, with reduced vulnerability to poor generalizability and poor acceptance of end-to-end ML approaches.