The integration of deep learning tools in gastrointestinal vision holds the potential for significant advancements in diagnosis, treatment, and overall patient care. A major challenge, however, is these tools' tendency to make overconfident predictions, even when encountering unseen or newly emerging disease patterns, undermining their reliability. We address this critical issue of reliability by framing it as an out-of-distribution (OOD) detection problem, where previously unseen and emerging diseases are identified as OOD examples. However, gastrointestinal images pose a unique challenge due to the overlapping feature representations between in- Distribution (ID) and OOD examples. Existing approaches often overlook this characteristic, as they are primarily developed for natural image datasets, where feature distinctions are more apparent. Despite the overlap, we hypothesize that the features of an in-distribution example will cluster closer to the centroids of their ground truth class, resulting in a shorter distance to the nearest centroid. In contrast, OOD examples maintain an equal distance from all class centroids. Based on this observation, we propose a novel nearest-centroid distance deficit (NCCD) score in the feature space for gastrointestinal OOD detection. Evaluations across multiple deep learning architectures and two publicly available benchmarks, Kvasir2 and Gastrovision, demonstrate the effectiveness of our approach compared to several state-of-the-art methods. The code and implementation details are publicly available at: https://github.com/bhattarailab/NCDD

Coronary Artery Diseases although preventable are one of the leading cause of mortality worldwide. Due to the onerous nature of diagnosis, tackling CADs has proved challenging. This study addresses the automation of resource-intensive and time-consuming process of manually detecting stenotic lesions in coronary arteries in X-ray coronary angiography images. To overcome this challenge, we employ a specialized Convnext-V2 backbone based Mask RCNN model pre-trained for instance segmentation tasks. Our empirical findings affirm that the proposed model exhibits commendable performance in identifying stenotic lesions. Notably, our approach achieves a substantial F1 score of 0.5353 in this demanding task, underscoring its effectiveness in streamlining this intensive process.