The use of artificial intelligence to enable precision medicine and decision support systems through the analysis of pathology images has the potential to revolutionize the diagnosis and treatment of cancer. Such applications will depend on models' abilities to capture the diverse patterns observed in pathology images. To address this challenge, we present Virchow, a foundation model for computational pathology. Using self-supervised learning empowered by the DINOv2 algorithm, Virchow is a vision transformer model with 632 million parameters trained on 1.5 million hematoxylin and eosin stained whole slide images from diverse tissue and specimen types, which is orders of magnitude more data than previous works. The Virchow model enables the development of a pan-cancer detection system with 0.949 overall specimen-level AUC across 17 different cancer types, while also achieving 0.937 AUC on 7 rare cancer types. The Virchow model sets the state-of-the-art on the internal and external image tile level benchmarks and slide level biomarker prediction tasks. The gains in performance highlight the importance of training on massive pathology image datasets, suggesting scaling up the data and network architecture can improve the accuracy for many high-impact computational pathology applications where limited amounts of training data are available.

This work investigates how hierarchically structured data can help neural networks learn conceptual representations of cathedrals. The underlying WikiScenes dataset provides a spatially organized hierarchical structure of cathedral components. We propose a novel hierarchical contrastive training approach that leverages a triplet margin loss to represent the data's spatial hierarchy in the encoder's latent space. As such, the proposed approach investigates if the dataset structure provides valuable information for self-supervised learning. We apply t-SNE to visualize the resultant latent space and evaluate the proposed approach by comparing it with other dataset-specific contrastive learning methods using a common downstream classification task. The proposed method outperforms the comparable weakly-supervised and baseline methods. Our findings suggest that dataset structure is a valuable modality for weakly-supervised learning.