Drug repurposing (or repositioning) is the process of finding new therapeutic uses for drugs already approved by drug regulatory authorities (e.g., the Food and Drug Administration (FDA) and Therapeutic Goods Administration (TGA)) for other diseases. This involves analyzing the interactions between different biological entities, such as drug targets (genes/proteins and biological pathways) and drug properties, to discover novel drug-target or drug-disease relations. Artificial intelligence methods such as machine learning and deep learning have successfully analyzed complex heterogeneous data in the biomedical domain and have also been used for drug repurposing. This study presents a novel unsupervised machine learning framework that utilizes a graph-based autoencoder for multi-feature type clustering on heterogeneous drug data. The dataset consists of 438 drugs, of which 224 are under clinical trials for COVID-19 (category A). The rest are systematically filtered to ensure the safety and efficacy of the treatment (category B). The framework solely relies on reported drug data, including its pharmacological properties, chemical/physical properties, interaction with the host, and efficacy in different publicly available COVID-19 assays. Our machine-learning framework reveals three clusters of interest and provides recommendations featuring the top 15 drugs for COVID-19 drug repurposing, which were shortlisted based on the predicted clusters that were dominated by category A drugs. The anti-COVID efficacy of the drugs should be verified by experimental studies. Our framework can be extended to support other datasets and drug repurposing studies, given open-source code and data availability.

Due to the high mutation rate of the virus, the COVID-19 pandemic evolved rapidly. Certain variants of the virus, such as Delta and Omicron, emerged with altered viral properties leading to severe transmission and death rates. These variants burdened the medical systems worldwide with a major impact to travel, productivity, and the world economy. Unsupervised machine learning methods have the ability to compress, characterize, and visualize unlabelled data. This paper presents a framework that utilizes unsupervised machine learning methods to discriminate and visualize the associations between major COVID-19 variants based on their genome sequences. These methods comprise a combination of selected dimensionality reduction and clustering techniques. The framework processes the RNA sequences by performing a k-mer analysis on the data and further visualises and compares the results using selected dimensionality reduction methods that include principal component analysis (PCA), t-distributed stochastic neighbour embedding (t-SNE), and uniform manifold approximation projection (UMAP). Our framework also employs agglomerative hierarchical clustering to visualize the mutational differences among major variants of concern and country-wise mutational differences for selected variants (Delta and Omicron) using dendrograms. We also provide country-wise mutational differences for selected variants via dendrograms. We find that the proposed framework can effectively distinguish between the major variants and has the potential to identify emerging variants in the future.

Google Translate has been prominent for language translation; however, limited work has been done in evaluating the quality of translation when compared to human experts. Sanskrit one of the oldest written languages in the world. In 2022, the Sanskrit language was added to the Google Translate engine. Sanskrit is known as the mother of languages such as Hindi and an ancient source of the Indo-European group of languages. Sanskrit is the original language for sacred Hindu texts such as the Bhagavad Gita. In this study, we present a framework that evaluates the Google Translate for Sanskrit using the Bhagavad Gita. We first publish a translation of the Bhagavad Gita in Sanskrit using Google Translate. Our framework then compares Google Translate version of Bhagavad Gita with expert translations using sentiment and semantic analysis via BERT-based language models. Our results indicate that in terms of sentiment and semantic analysis, there is low level of similarity in selected verses of Google Translate when compared to expert translations. In the qualitative evaluation, we find that Google translate is unsuitable for translation of certain Sanskrit words and phrases due to its poetic nature, contextual significance, metaphor and imagery. The mistranslations are not surprising since the Bhagavad Gita is known as a difficult text not only to translate, but also to interpret since it relies on contextual, philosophical and historical information. Our framework lays the foundation for automatic evaluation of other languages by Google Translate