Instead of "ground truth" one may only have the subjective opinion(s) of one or more experts. For example, medical data or image data may be collected off-line and some time later a set of experts analyze the data and produce a set of class labels. The central problem is that of trying to infer the "ground truth" given the noisy subjective estimates of the experts. When one wishes to apply a supervised learning algorithm to the data, the problem is primarily twofold: (i) how to evaluate the relative performance of experts and algorithms, and (ii) how to train a pattern recognition system in the absence of absolute ground truth. In this paper we focus on problem (i), namely the performance evaluation issue, and in particular we discuss the application of a particular modelling technique to the problem of counting volcanoes on the surface of Venus.

We apply HMMs to the problem of modeling exons, intronsand detecting splice sites in the human genome. Our most interesting result so far is the detection of particular oscillatory patterns,with a minimal period ofroughly 10 nucleotides, that seem to be characteristic of exon regions and may have significant biological implications.

Human genes are not continuous but rather consist of short coding regions (exons) interspersed with highly variable non-coding regions (introns). We apply HMMs to the problem of modeling exons, introns and detecting splice sites in the human genome. Our most interesting result so far is the detection of particular oscillatory patterns, with a minimal period ofroughly 10 nucleotides, that seem to be characteristic of exon regions and may have significant biological implications.

Hidden Markov Models (HMMs) can be applied to several important problems in molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, and classification.

Hidden Markov Models (HMMs) can be applied to several important problems in molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, and classification.

Hidden Markov Models (HMMs) can be applied to several important problemsin molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, andclassification.

Bell-shaped response curves are commonly found in biological neurons whenever a natural metric exist on the corresponding relevant stimulus variable (orientation, position in space, frequency, time delay,...). As a result, they are often used in neural models in different context ranging from resolution enhancement and interpolation to learning (see, for instance, Baldi et al. (1988), Moody et al. (1989) *and Division of Biology, California Institute of Technology. The complete title of this paper should read: "Computing with arrays of bell-shaped and sigmoid functions.

Bell-shaped response curves are commonly found in biological neurons whenever a natural metric exist on the corresponding relevant stimulus variable (orientation, position in space, frequency, time delay, ...). As a result, they are often used in neural models in different context ranging from resolution enhancement and interpolation tolearning (see, for instance, Baldi et al. (1988), Moody et al. (1989) *and Division of Biology, California Institute of Technology. The complete title of this paper should read: "Computing with arrays of bell-shaped and sigmoid functions.

Minimization of energy or error functions has proved to be a useful principle in the design and analysis of neural networks and neural algorithms. A brief list of examples include: the back-propagation algorithm, the use of optimization methods in computational vision, the application of analog networks to the approximate solution of NP complete problems and the Hopfield model of associative memory.

Minimization of energy or error functions has proved to be a useful principle in the design and analysis of neural networks and neural algorithms. A brief list of examples include: the back-propagation algorithm, the use of optimization methods in computational vision, the application of analog networks to the approximate solution of NP complete problems and the Hopfield model of associative memory.