Aussó, Susanna
FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare
Lekadir, Karim, Feragen, Aasa, Fofanah, Abdul Joseph, Frangi, Alejandro F, Buyx, Alena, Emelie, Anais, Lara, Andrea, Porras, Antonio R, Chan, An-Wen, Navarro, Arcadi, Glocker, Ben, Botwe, Benard O, Khanal, Bishesh, Beger, Brigit, Wu, Carol C, Cintas, Celia, Langlotz, Curtis P, Rueckert, Daniel, Mzurikwao, Deogratias, Fotiadis, Dimitrios I, Zhussupov, Doszhan, Ferrante, Enzo, Meijering, Erik, Weicken, Eva, González, Fabio A, Asselbergs, Folkert W, Prior, Fred, Krestin, Gabriel P, Collins, Gary, Tegenaw, Geletaw S, Kaissis, Georgios, Misuraca, Gianluca, Tsakou, Gianna, Dwivedi, Girish, Kondylakis, Haridimos, Jayakody, Harsha, Woodruf, Henry C, Aerts, Hugo JWL, Walsh, Ian, Chouvarda, Ioanna, Buvat, Irène, Rekik, Islem, Duncan, James, Kalpathy-Cramer, Jayashree, Zahir, Jihad, Park, Jinah, Mongan, John, Gichoya, Judy W, Schnabel, Julia A, Kushibar, Kaisar, Riklund, Katrine, Mori, Kensaku, Marias, Kostas, Amugongo, Lameck M, Fromont, Lauren A, Maier-Hein, Lena, Alberich, Leonor Cerdá, Rittner, Leticia, Phiri, Lighton, Marrakchi-Kacem, Linda, Donoso-Bach, Lluís, Martí-Bonmatí, Luis, Cardoso, M Jorge, Bobowicz, Maciej, Shabani, Mahsa, Tsiknakis, Manolis, Zuluaga, Maria A, Bielikova, Maria, Fritzsche, Marie-Christine, Linguraru, Marius George, Wenzel, Markus, De Bruijne, Marleen, Tolsgaard, Martin G, Ghassemi, Marzyeh, Ashrafuzzaman, Md, Goisauf, Melanie, Yaqub, Mohammad, Ammar, Mohammed, Abadía, Mónica Cano, Mahmoud, Mukhtar M E, Elattar, Mustafa, Rieke, Nicola, Papanikolaou, Nikolaos, Lazrak, Noussair, Díaz, Oliver, Salvado, Olivier, Pujol, Oriol, Sall, Ousmane, Guevara, Pamela, Gordebeke, Peter, Lambin, Philippe, Brown, Pieta, Abolmaesumi, Purang, Dou, Qi, Lu, Qinghua, Osuala, Richard, Nakasi, Rose, Zhou, S Kevin, Napel, Sandy, Colantonio, Sara, Albarqouni, Shadi, Joshi, Smriti, Carter, Stacy, Klein, Stefan, Petersen, Steffen E, Aussó, Susanna, Awate, Suyash, Raviv, Tammy Riklin, Cook, Tessa, Mutsvangwa, Tinashe E M, Rogers, Wendy A, Niessen, Wiro J, Puig-Bosch, Xènia, Zeng, Yi, Mohammed, Yunusa G, Aquino, Yves Saint James, Salahuddin, Zohaib, Starmans, Martijn P A
Despite major advances in artificial intelligence (AI) for medicine and healthcare, the deployment and adoption of AI technologies remain limited in real-world clinical practice. In recent years, concerns have been raised about the technical, clinical, ethical and legal risks associated with medical AI. To increase real world adoption, it is essential that medical AI tools are trusted and accepted by patients, clinicians, health organisations and authorities. This work describes the FUTURE-AI guideline as the first international consensus framework for guiding the development and deployment of trustworthy AI tools in healthcare. The FUTURE-AI consortium was founded in 2021 and currently comprises 118 inter-disciplinary experts from 51 countries representing all continents, including AI scientists, clinicians, ethicists, and social scientists. Over a two-year period, the consortium defined guiding principles and best practices for trustworthy AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. The FUTURE-AI framework was established based on 6 guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 28 best practices were defined, addressing technical, clinical, legal and socio-ethical dimensions. The recommendations cover the entire lifecycle of medical AI, from design, development and validation to regulation, deployment, and monitoring. FUTURE-AI is a risk-informed, assumption-free guideline which provides a structured approach for constructing medical AI tools that will be trusted, deployed and adopted in real-world practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of medical AI.
FUTURE-AI: Guiding Principles and Consensus Recommendations for Trustworthy Artificial Intelligence in Future Medical Imaging
Lekadir, Karim, Osuala, Richard, Gallin, Catherine, Lazrak, Noussair, Kushibar, Kaisar, Tsakou, Gianna, Aussó, Susanna, Alberich, Leonor Cerdá, Marias, Konstantinos, Tskinakis, Manolis, Colantonio, Sara, Papanikolaou, Nickolas, Salahuddin, Zohaib, Woodruff, Henry C, Lambin, Philippe, Martí-Bonmatí, Luis
The recent advancements in artificial intelligence (AI) combined with the extensive amount of data generated by today's clinical systems, has led to the development of imaging AI solutions across the whole value chain of medical imaging, including image reconstruction, medical image segmentation, image-based diagnosis and treatment planning. Notwithstanding the successes and future potential of AI in medical imaging, many stakeholders are concerned of the potential risks and ethical implications of imaging AI solutions, which are perceived as complex, opaque, and difficult to comprehend, utilise, and trust in critical clinical applications. Despite these concerns and risks, there are currently no concrete guidelines and best practices for guiding future AI developments in medical imaging towards increased trust, safety and adoption. To bridge this gap, this paper introduces a careful selection of guiding principles drawn from the accumulated experiences, consensus, and best practices from five large European projects on AI in Health Imaging. These guiding principles are named FUTURE-AI and its building blocks consist of (i) Fairness, (ii) Universality, (iii) Traceability, (iv) Usability, (v) Robustness and (vi) Explainability. In a step-by-step approach, these guidelines are further translated into a framework of concrete recommendations for specifying, developing, evaluating, and deploying technically, clinically and ethically trustworthy AI solutions into clinical practice.