The topic of deep learning systems has received significant attention during the past few years, particularly as a biologically-inspired approach to processing highdimensional signals. The latter often involve spatiotemporal information that may span large scales, rendering its representation in the general case highly challenging. Deep learning networks attempt to overcome this challenge by means of a hierarchical architecture that is comprised of common circuits with similar (and often cortically influenced) functionality. The goal of such systems is to represent sensory observations in a manner that will later facilitate robust pattern classification, mimicking a key attribute of the mammal brain. This stands in contrast with the mainstream approach of pre-processing the data so as to reduce its dimensionality — a paradigm that often results in sub-optimal performance. This paper presents a Deep SpatioTemporal Inference Network (DeSTIN) — a scalable deep learning architecture that relies on a combination of unsupervised learning and Bayesian inference. Dynamic pattern learning forms an inherent way of capturing complex spatiotemporal dependencies. Simulation results demonstrate the core capabilities of the proposed framework, particularly in the context of high-dimensional signal classification.